HIIT for Coronary Artery Disease

Overseen By Rahel Askari

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Virginia

Disqualifiers: Systolic heart failure, Myocardial infarction, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 4 weeks

25 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore why individuals with Angina and No Obstructive Coronary Artery Disease (ANOCA) often experience reduced fitness and how it affects their lives. Researchers seek to determine if a remotely monitored high-intensity interval training (HIIT) program can enhance heart health, fitness, and quality of life for these patients. The trial uses a special exercise test to identify exercise limitations before and after the program. Individuals who experience chest pain or shortness of breath without blocked arteries and can commit to a remote exercise program may be suitable for this study. As an unphased trial, this study offers a unique opportunity to contribute to understanding and improving life with ANOCA.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this exercise program is safe for patients with ANOCA?

Studies have shown that high-intensity interval training (HIIT) can be safe for people with coronary artery disease. Research indicates that HIIT has a low rate of major heart-related events, making serious problems like heart attacks rare. In fact, HIIT might surpass regular exercise in improving heart fitness, such as enhancing the heart's ability to pump blood during exercise.

Other studies have found that HIIT can improve overall heart function and fitness levels, helping the heart work better and making everyday activities easier. While serious problems are uncommon, consulting doctors before starting any new exercise program is always important. They can ensure HIIT suits each person's health needs. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about high-intensity interval training (HIIT) for coronary artery disease because it offers a fresh approach compared to traditional treatments like medication, lifestyle changes, and surgery. Unlike typical exercise regimens that can be long and moderate, HIIT involves short bursts of intense activity followed by rest, potentially leading to quicker improvements in heart health. This method is designed to be more time-efficient, making it easier for people to fit into their busy lives. Additionally, HIIT might improve cardiovascular fitness more effectively in a shorter period, which could be a game-changer for managing coronary artery disease.

What evidence suggests that this exercise training is effective for improving fitness in ANOCA?

This trial will evaluate the effects of high-intensity interval training (HIIT) on individuals with coronary artery disease. Studies have shown that HIIT can greatly improve heart health and fitness. For those with heart conditions like coronary artery disease, HIIT enhances important heart functions more effectively than moderate exercise. Research indicates that HIIT increases peak oxygen uptake (VO2 peak), a sign of better fitness. It also appears safe for heart patients, with a low risk of major heart-related problems. Overall, HIIT shows promise for improving heart function and quality of life in individuals with heart health issues. ^{2 3 5 6 7}

Who Is on the Research Team?

Jamieson M Bourque, MD, MHS

Principal Investigator

University of Virginia

Are You a Good Fit for This Trial?

This trial is for patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) who experience reduced fitness and quality of life due to their condition. Specific eligibility criteria are not provided, but typically include a diagnosis of ANOCA, ability to perform exercise, and no contraindications to high-intensity training.

Inclusion Criteria

Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English

Able to use the wearable and participate in a remote exercise program

Able to participate in intermittent high-intensity training

Exclusion Criteria

Inability to provide informed consent

Life expectancy <1 year

Prisoners

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo cardiopulmonary exercise testing (CPET) to assess exercise workload, hemodynamic variables, and health-related quality of life (HRQOL) measurement

1 week

1 visit (in-person)

Treatment

Participants engage in a 4-week high-intensity interval training (HIIT) program with remote monitoring using Polar heart rate devices

4 weeks

1 visit (in-person), remote monitoring

Follow-up

Participants are reassessed for cardiorespiratory fitness and health-related quality of life after the HIIT intervention

1 week

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Exercise Training

Trial Overview The study is examining the impact of a remote high-intensity interval training (HIIT) program on heart function, cardiorespiratory fitness, and quality of life in ANOCA patients. It involves cardiopulmonary exercise testing before and after the intervention to assess improvements.

How Is the Trial Designed?

Group I: Exercise Experimental Treatment 1 Intervention

Remote 4 weeks of high-intensity interval exercise training on three non-consecutive days of the week.

Who Is Running the Clinical Trial?

University of Virginia

Lead Sponsor

Trials

802

Recruited

1,342,000+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9203221/

The Effects of High-Intensity Interval Training on Exercise ... Finally, in heart disease (including CAD and HF), HIIT significantly improved the AT and LVEF compared with MICT, without showing changes in the VE/VCO2 slope ...

2. ahajournals.org ahajournals.org/doi/10.1161/JAHA.118.009305

High‐Intensity Interval Training for Patients With ... HIIT has shown a relatively low rate of major adverse cardiovascular events for patients with coronary artery disease or heart failure when applied within CR ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S0003999323005294

Cost-effectiveness of High-Intensity Interval Training (HIIT) ... In a recent randomized controlled trial, high-intensity interval exercise training (HIIT) was more effective than moderate intensity steady-state (MISS) ...

4. journals.plos.org journals.plos.org/plosone/article?id=10.1371/journal.pone.0314134

Effects of high-intensity interval training versus moderate ... Based on the findings of this systematic review, HIIT demonstrates superior efficacy compared to MICT in enhancing PeakVO2, PHR, 6MWT and DBP.

5. jamanetwork.com jamanetwork.com/journals/jamacardiology/fullarticle/2769884

Short-term and Long-term Feasibility, Safety, and Efficacy ... A number of single-center trials have demonstrated a 2-fold increase in VO2 peak with HIIT compared with MICT. In contrast, the multicenter ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8046134/

Effects of high‐intensity interval training in patients with ... Summarily, HIIT programme appears to be favourable for CAD patients after PCI by improving cardiopulmonary function, such as LVEF and VO2peak, as well as ...

7. sciencedirect.com sciencedirect.com/science/article/abs/pii/S1877065724000629

Review Effects of high-intensity interval training on ... Moderate- to high-quality evidence supported that HIIT is superior to MICT in improving VO 2 peak for CAD.