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Pediatric Cancer Clinical Trials 2022
Pediatric Cancer studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect pediatric cancer clinical trial in 2022.
Condition
Pediatric Cancer
Location
Distance
10 Miles
Any
Age
Search
Clinical Trials
Pediatric Cancer Clinical Trials 2022
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Dinutuximab With Chemotherapy
for Neuroblastoma
Los Angeles, CA
Any Age
All Sexes
Phase 4
Waitlist Available
Grade II
Los Angeles, CA
Any Age
All Sexes
Studies have shown that the anti-GD2 human-mouse chimeric monoclonal antibody dinutuximab has contributed significantly to the improvement of treatment for children with high-risk neuroblastoma and has become a mainstay in treating high risk neuroblastoma in children as part of up-front therapy and relapsed/refractory therapy. The administration of dinutuximab requires a significant amount of time and resources to complete the 10-20 hour standard infusion time for 4 days in the inpatient setting. During its early development, a phase I study profiling the clinical efficacy and tolerability of dinutuximab infusions in children successfully infused dinutuximab at various rates including over 1 hour at different dose levels. In the adult setting, dinutuximab has been tolerated over substantially shorter infusion times (less than 2 hours). Additionally, another anti-GD2 murine monoclonal antibody naxitamab, which has a similar toxicity profile to dinutuximab, is FDA approved for administration over 90 minutes and is successfully administered in outpatient setting. Given this reassuring data we aim to evaluate the feasibility of the rapid administration of dinutuximab over four hours or less in our patient population of children with high-risk neuroblastoma. The pharmacokinetics, toxicity profile and supportive care requirements will be analyzed and described in order to determine if rapid infusion of dinutuximab can be successfully tolerated over four hours or less which would allow for administration of this agent in the outpatient setting. Should this trial prove to be successful, it would serve to decrease the hospital burden in a positive way by allowing for administration of this immunotherapy agent in the outpatient setting and patients may prefer shorter infusion duration. Furthermore, it could lessen overall costs and inpatient admissions for patients.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Clinician Barrier Reports
for Adherence, Medication
Buffalo, NY
Any Age
All Sexes
Recruiting
Buffalo, NY
Any Age
All Sexes
To develop a cancer center level practice intervention to promote treatment adherence and reduce outcome disparities in pediatric cancer survivors
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Adaptive Attention Training
for Pediatrics Cancer
San Francisco, CA
< 18
All Sexes
Waitlist Available
San Francisco, CA
< 18
All Sexes
This study is evaluating whether a novel, adaptive attention training can improve cognitive and behavioral outcomes in pediatric cancer survivors.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Cyclophosphamide
for Neuroblastoma
New York, NY
< 18
All Sexes
Phase < 1
Recruiting
Metastatic
New York, NY
< 18
All Sexes
This study is evaluating whether a drug called N9 is safe and effective for children with neuroblastoma.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Healthy Lifestyles
for Pediatrics Cancer
Saint Petersburg, FL
< 65
All Sexes
Waitlist Available
1 Prior Treatment
Saint Petersburg, FL
< 65
All Sexes
This study is evaluating whether a healthy lifestyle intervention may help improve the health of adolescent and young adult survivors of pediatric cancer.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Tranexamic Acid
for Limb Salvage
Memphis, TN
< 65
All Sexes
Phase 3
Recruiting
Memphis, TN
< 65
All Sexes
This is a randomized double-blind control trial evaluating the use Tranexamic acid (TXA) to decrease blood loss and transfusion requirements in pediatric and young adult cancer patients undergoing a limb salvage procedure that frequently requires perioperative or post-operative transfusions of blood products. Primary Objective To evaluate the difference in intra-or post-operatively transfused blood volume (mL/kg) for patients undergoing limb salvage procedures of the distal femur or proximal tibia who are randomized to receive perioperative tranexamic acid (TXA) versus placebo. Secondary Objectives To evaluate changes in platelets and in hemoglobin from pre-op to post-op level for patients randomized to receive perioperative TXA versus placebo. To evaluate differences in post-operative daily surgical drain output for patients randomized to receive perioperative TXA versus placebo. To evaluate changes in estimated blood loss (EBL) for patients randomized to receive perioperative TXA versus placebo. To evaluate the association between the intra-or post-operatively transfused blood volume and estimated blood loss (EBL) for patients randomized to receive perioperative TXA and placebo, respectively. Exploratory Objectives To evaluate differences in functional outcomes post-operatively for patients randomized to receive perioperative TXA versus placebo. To explore if significant correlations are observed between parameters reported with rotational thromboelastometry (ROTEM®) and EBL and transfusion requirements in pediatric and young adult patients undergoing limb salvage procedure who are randomized to perioperative TXA versus placebo. To evaluate differences in the prevalence and management of wound complications such as superficial or periprosthetic infections, wound dehiscence, contact dermatitis, post- operative hematomas, or any other clinically significant wound complication between patients randomized to receive perioperative TXA versus placebo.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Panitumumab-IRDye800
for Neoplasms, Brain
Stanford, CA
< 65
All Sexes
Phase 1 & 2
Waitlist Available
Stanford, CA
< 65
All Sexes
This study is evaluating whether a drug used to treat cancer may be safe for use in children.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
BMS-986158
for Lymphoma
Seattle, WA
< 65
All Sexes
Phase 1
Recruiting
Grade I
Seattle, WA
< 65
All Sexes
This study is evaluating whether a drug may help treat children with cancer.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Granulocyte Colony-Stimulating Factor
for Neutropenia
Jackson, MS
< 65
All Sexes
Phase 4
Waitlist Available
Jackson, MS
< 65
All Sexes
This study is evaluating whether a medication given after chemotherapy can help reduce the risk of infection.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
ALRN-6924
for Lymphoma
Philadelphia, PA
< 65
All Sexes
Phase 1
Recruiting
Grade II
Philadelphia, PA
< 65
All Sexes
This research study is studying a novel drug called ALRN-6924 as a possible treatment for resistant (refractory) solid tumor, brain tumor, lymphoma or leukemia. The drugs involved in this study are: ALRN-6924 Cytarabine (for patients with leukemia only)
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Optune NovoTTF-200A System
for Ependymoma
Hackensack, NJ
< 65
All Sexes
Phase 1
Recruiting
Grade II
Hackensack, NJ
< 65
All Sexes
This study is evaluating whether a device which delivers alternating electric fields to the brain may help treat children with recurrent brain tumors.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Indocyanine Green (ICG)
for Pediatric Patients With Solid Tumors
New York, NY
< 65
All Sexes
Phase 2 & 3
Waitlist Available
New York, NY
< 65
All Sexes
This study is being done in patients that have tumors to find out how well sentinel lymph nodes (SLNs) can be found with a special dye called indocyanine green (ICG).
1
Other Trials to Consider
Topiramate Tablets
for Pediatric Obesity
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Phase < 1
Recruiting
Minneapolis, MN
< 65
All Sexes
Indocyanine Green (ICG)
for Pediatric Patients With Solid Tumors
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2 & 3
Waitlist Available
New York, NY
< 65
All Sexes
Asciminib Pediatric Formulation Group
for Myeloid Leukemia, Philadelphia Positive
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Phase 1 & 2
Recruiting
Boston, MA
< 65
All Sexes
Durvalumab / Tremelimumab Combination Therapy
for Pediatrics Cancer
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Phase 1 & 2
Recruiting
Locally Advanced
New Hyde Park, NY
< 65
All Sexes
Cryoablation Therapy
for Rhabdomyosarcoma
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Metastatic
Washington, United States
< 65
All Sexes
COVID-19 Vaccine Uptake App
for Telemedicine
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Omaha, NE
18+
All Sexes
Paro Robot
for Animal Assisted Therapy
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Omaha, NE
< 65
All Sexes
IFIT Prosthesis
for ALL, Pediatric
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Philadelphia, PA
< 18
All Sexes
Parenting Mindfully For Health Nutrition (PMH)
for Pediatric Obesity
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Waitlist Available
New Haven, CT
< 18
All Sexes
HALO
for Pediatric Obesity
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Cincinnati, OH
Any Age
Female
PCIT-Health
for Obesity, Child
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Waitlist Available
Mount Pleasant, MI
< 18
All Sexes
Dyad Plus
for Pediatric Obesity
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Winston-Salem, NC
Any Age
All Sexes
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