Reviewed by Michael Gill, B. Sc.
Image of Saint Joseph's Health Care London in London, Canada.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Skin Involvementfor Sclerosis

18+
All Sexes
Systemic Sclerosis (SSc) is an autoimmune connective tissue disease characterized by autoantibodies, fibrosis and microvascular injury and endothelial cell activation that results in vascular damage. Vascular injury induces both innate and acquired immune responses resulting in fibroblast activation and organ fibrosis. SSc may target multiple organs, including: skin, lungs, heart, vascularization, kidneys, the gastrointestinal tract and musculoskeletal structures. Mortality among scleroderma patients is significant, with a 3.5 standardized mortality ratio (SMR) in studies of prevalent cases. This mortality may be increased in the early years of the disease, reaching a SMR of 4 in a multinational inception cohort. In general, treatment strategies target involved organs as early as possible to avoid damage. Many treatment options are available for each manifestation, but evidence with respect to the order of treatment is scarce. Financial costs, the lack of proper outcome measures, difficulty to recruit patients as a rare disease, all prevent the development of new big clinical trials, oppositely to other common diseases such as stroke or cancer. The heterogeneous features of SSc may make trials challenging. The current guidelines available are the British guidelines (2017) , and the updated European League Against Rheumatism (EULAR) guidelines, published in 2017. Management guidelines have some gaps regarding second-line treatment, combinations and there are no proposed algorithms. With the pragmatic trials, the investigators intend to fill the gap between the complicated randomized clinical trials and the observational studies. Using the treatments that have already been proved useful in SSc, in an open-label randomized way and based on some refined expert-made algorithms, will allow the investigators to establish the order in how to use them. Patients will be offered to participate with the collection of their clinical data and, if they give their consent, they will be randomized according to the algorithms. There will be an optional part of the study consisting in the collection of blood samples and skin samples for future research.
Waitlist Available
Has No Placebo
Saint Joseph's Health Care London
17 Scleroderma Clinical Trials Near Me
Top Hospitals for Scleroderma Clinical Trials
Image of Rheumatology Clinic, St. Joseph's Health Care in Ontario.
Rheumatology Clinic, St. Joseph's Health Care
London
2Active Trials
3All Time Trials for Scleroderma
2018First Scleroderma Trial
Image of University of Michigan in Michigan.
University of Michigan
Ann Arbor
2Active Trials
20All Time Trials for Scleroderma
2005First Scleroderma Trial
Top Cities for Scleroderma Clinical Trials
Image of New York in New York.
New York
5Active Trials
Hospital for Special SurgeryTop Active Site
Scleroderma Clinical Trials by Phase of Trial
Most Recent Scleroderma Clinical Trials
Top Treatments for Scleroderma Clinical Trials
Treatment Name
Active Scleroderma Clinical Trials
All Time Trials for Scleroderma
First Recorded Scleroderma Trial
Brentuximab Vedotin
2
2
2017
Electron Beam Therapy
1
1
2023
COVID-19 vaccine
1
1
2022
Extracorporeal Photopheresis (ECP) with Methoxsalen
1
1
2022
RENEW
1
1
2021

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: November 9th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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