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39 Scleroderma Trials Near You
Power is an online platform that helps thousands of Scleroderma patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
Learn More About PowerNivolumab for Cancer
Trial Details
Key Eligibility Criteria
300 Participants Needed
HZN-825 for Systemic Sclerosis
Trial Details
Key Eligibility Criteria
301 Participants Needed
SYNCAR-001 + STK-009 for Lupus
Trial Details
Key Eligibility Criteria
48 Participants Needed
CC-97540 for Severe Refractory Lupus
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Key Eligibility Criteria
144 Participants Needed
BMS-986278 for Pulmonary Fibrosis
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Key Eligibility Criteria
1092 Participants Needed
Anifrolumab for Systemic Sclerosis
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Key Eligibility Criteria
306 Participants Needed
BI 685509 for Systemic Sclerosis
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Key Eligibility Criteria
188 Participants Needed
Belimumab for Systemic Sclerosis Interstitial Lung Disease
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Key Eligibility Criteria
300 Participants Needed
PRA023 for Systemic Sclerosis-Associated ILD
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Key Eligibility Criteria
152 Participants Needed
Amlitelimab + BI 1015550 for Scleroderma
Trial Details
Key Eligibility Criteria
400 Participants Needed
Efzofitimod for Scleroderma-Related Lung Disease
Trial Details
Key Eligibility Criteria
25 Participants Needed
Vixarelimab for Pulmonary Fibrosis
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Key Eligibility Criteria
320 Participants Needed
Ianalumab for Systemic Sclerosis
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Key Eligibility Criteria
200 Participants Needed
Brain Boost Program for Scleroderma
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Key Eligibility Criteria
66 Participants Needed
AI Health Coach for Scleroderma
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Key Eligibility Criteria
20 Participants Needed
Tibulizumab for Scleroderma
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Key Eligibility Criteria
80 Participants Needed
Rapcabtagene Autoleucel for Systemic Sclerosis
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Key Eligibility Criteria
86 Participants Needed
CABA-201 for Scleroderma
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Key Eligibility Criteria
12 Participants Needed
HZN-825 for Scleroderma
Trial Details
Key Eligibility Criteria
240 Participants Needed
TENS for Scleroderma
Trial Details
Key Eligibility Criteria
16 Participants Needed
Why Other Patients Applied
"I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."
"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."
"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."
"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."
"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."
Apollo Device for Scleroderma
Trial Details
Key Eligibility Criteria
160 Participants Needed
Efgartigimod for Scleroderma
Trial Details
Key Eligibility Criteria
81 Participants Needed
Sodium Thiosulfate for Calcinosis
Trial Details
Key Eligibility Criteria
20 Participants Needed
NKX019 for Systemic Sclerosis
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Key Eligibility Criteria
72 Participants Needed
Stem Cell Transplant for Scleroderma
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Key Eligibility Criteria
8 Participants Needed
Brentuximab Vedotin for Systemic Sclerosis
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Key Eligibility Criteria
11 Participants Needed
Extracorporeal Photopheresis for Systemic Sclerosis
Trial Details
Key Eligibility Criteria
15 Participants Needed
Diosmin for Digital Ulcers
Trial Details
Key Eligibility Criteria
45 Participants Needed
CTX112 for Lupus
Trial Details
Key Eligibility Criteria
80 Participants Needed
CNTY-101 for Lupus
Trial Details
Key Eligibility Criteria
48 Participants Needed
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We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.
Frequently Asked Questions
How much do Scleroderma clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
How do Scleroderma clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Scleroderma trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Scleroderma is 12 months.
How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Do I need to be insured to participate in a Scleroderma medical study?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
What are the newest Scleroderma clinical trials?
Most recently, we added Stem Cell Transplant for Autoimmune Diseases, Extracorporeal Photopheresis for Systemic Sclerosis and AlloNK + Rituximab for Rheumatic Diseases to the Power online platform.
Is there hope for scleroderma?
Yes—although scleroderma still has no one-shot cure, survival and quality of life have improved dramatically thanks to earlier organ screening, targeted drugs that slow lung and skin damage, and even stem-cell transplants for the most aggressive cases. Prognosis varies by subtype, but many people—especially with limited disease—now live full lifespans when they partner with a rheumatology team, stay vigilant for lung or heart changes, and tap into clinical trials and support resources. In short, progress is real and ongoing, so there truly is hope.
What is the best hospital in the US for scleroderma?
No agency publishes an official “#1 hospital” for scleroderma, so experts judge centers by patient volume, multidisciplinary specialists, active clinical trials, and research output. Programs that consistently meet those benchmarks include Johns Hopkins (MD), University of Pittsburgh Medical Center (PA), Hospital for Special Surgery/Columbia (NY), Stanford (CA), Mayo Clinic (MN), Cleveland Clinic (OH), and Brigham and Women’s (MA). Ask any prospective center about how many scleroderma patients it sees each year, what organ-specific teams and trials are available, and whether telehealth or second-opinion services fit your insurance and travel limits.
What triggers scleroderma?
Scleroderma starts when a person who already carries several “risk” genes experiences an additional hit—most convincingly long-term exposure to silica dust or strong organic solvents, certain chemotherapy drugs (e.g., bleomycin), or, in a minority, an immune reaction linked to a recent cancer or infection. These triggers injure the small blood-vessel lining, the immune system over-reacts, and excess collagen is laid down, thickening skin and sometimes organs; however, in many patients no definite trigger is ever found, which is why avoiding heavy chemical exposure and staying up-to-date with routine health checks is wise but cannot fully prevent the disease.
What would you not recommend for a patient with scleroderma?
Think “anything that injures fragile skin, clamps down blood flow, or stresses the kidneys”—those are the main things to avoid in scleroderma. That means skipping tattoos or piercings; quitting smoking, vaping, or other nicotine; keeping fingers warm and steering clear of cold aisles or ice water; and avoiding medicines that tighten blood vessels (certain decongestants, non-selective beta-blockers, migraine ergot/triptan drugs) or high-dose steroids and other kidney-toxic drugs unless your specialist says otherwise. Review every new procedure or medication with your rheumatologist so safer substitutes or protections can be arranged.
How much does it cost to treat scleroderma?
Treating scleroderma can run anywhere from about US $10–25 k per year for milder cases that need mainly clinic visits, routine tests and inexpensive medicines, to well over US $50 k—and sometimes above US $100 k—when lung or heart complications require drugs like nintedanib, bosentan or prostacyclin infusions, frequent hospital stays, or stem-cell transplant. The number you personally face depends far more on disease severity and insurance coverage than on any single “sticker price,” so the smartest move is to have your care team outline the expected treatments up front and, at the same time, apply for insurer pre-authorisation and drug-company or charity copay programs that can slash out-of-pocket costs.
Is scleroderma worse than rheumatoid arthritis?
It depends on what you mean by “worse.” Systemic scleroderma is rarer but more life-threatening because it can scar internal organs; even with modern care, about 15–30 % of patients die within 10 years. Rheumatoid arthritis is less deadly but far more common and can severely damage joints and raise heart-disease risk if untreated. In short, scleroderma carries the higher risk of early death, while rheumatoid arthritis more often causes long-term disability—early diagnosis and aggressive treatment are crucial for both.
What is a good supplement for scleroderma?
Start by correcting any lab-proven deficiencies—vitamin D is low in many people with scleroderma, so your doctor may suggest 800–2,000 IU (or the dose needed to reach normal blood levels). After that, the best-studied add-ons are marine fish-oil (about 1–3 g EPA + DHA daily) and N-acetyl-cysteine, which small studies suggest can ease Raynaud’s attacks and digital ulcers; high-dose iron or vitamin A should be avoided unless you are clearly deficient. Always clear supplements with your rheumatologist or pharmacist, as kidney, lung, or esophageal involvement—and the drugs used to treat them—can change what is safe for you.
What are the new treatments for scleroderma?
Two medicines are now FDA-approved to slow lung damage in systemic sclerosis: nintedanib (approved 2019) and tocilizumab (approved 2021). Beyond these, several therapies are showing benefit in late-stage studies—B-cell depletion with rituximab, T-cell modulation with abatacept, JAK inhibitors, cannabinoid-mimetic lenabasum, and autologous stem-cell transplant—so a rheumatologist may discuss clinical-trial or specialty-center referral if standard drugs are not enough.
How debilitating is scleroderma?
Scleroderma ranges from localized skin thickening that is more of a nuisance to a systemic form that can stiffen joints, cause painful Raynaud’s attacks, and—if it scars the lungs, heart or kidneys—significantly cut stamina or even shorten life; fortunately, only a subset of patients develop these severe complications. Thanks to earlier diagnosis, blood-pressure drugs that prevent kidney crisis, medications that slow lung scarring, and physical/occupational therapy, most people now remain independent and 10-year survival is roughly 75–85 %, so close monitoring with a rheumatologist is key to limiting how debilitating the disease becomes.
Does walking help scleroderma?
Yes—done correctly, regular walking can help many people with scleroderma by improving blood flow to the fingers and toes, keeping joints and skin less stiff, and boosting heart-lung fitness and energy levels; small studies even show gains in grip strength and walking distance after supervised programs. Start with short, comfortable walks (5-10 minutes) on level ground, dress warmly to protect against Raynaud’s, use well-fitting shoes if you have foot ulcers, and have your doctor or physiotherapist adjust the plan if you have lung involvement or pulmonary hypertension. Think of walking as one part of an overall movement routine—aim for about 150 minutes a week of gentle activity, adding stretching or hand exercises—as tolerated and monitored by your care team.