Preventative Skin Care for Pediatric Brain Cancer

Recruiting at 1 trial location

Overseen By Jennifer Huang, MD

Age: < 65

Sex: Any

Trial Phase: Phase 2

Sponsor: Dana-Farber Cancer Institute

Must be taking: BRAF, MEK, Pan-RAF inhibitors

Disqualifiers: Allergic reactions, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 3

Duration: 12 weeks

14 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial tests a skin care routine for children with brain tumors undergoing cancer treatments. The routine includes gentle skin care, sun protection, and bleach baths. It aims to reduce skin problems caused by the treatments.

Research Team

Jennifer Huang, MD

Principal Investigator

Boston Children's Hospital

Eligibility Criteria

This trial is for children aged 6 months to 18 years with a brain tumor, who will be treated with specific targeted therapies (BRAF, MEK, or pan-RAF inhibitors). They must be able to follow a skin care routine including sun protection and bleach baths. Children with allergies to sunscreen or skincare products used in the study cannot participate.

Inclusion Criteria

I can follow skin care rules including sun protection and bleach baths.

Subjects may participate in other studies, including therapeutic trials

I was diagnosed with a brain tumor as a child and will be treated with targeted therapy.

Exclusion Criteria

You have had allergic reactions to sunscreen or skin creams that will be used in this study.

You have had an allergic reaction to bleach in the past.

I was diagnosed with a brain tumor as an adult.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a preventative skin care regimen including daily sun protection, daily gentle skin care, and every-other-day dilute bleach baths during their anti-cancer treatment

12 weeks

3 visits (in-person) at start, 6 weeks, and 12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Dilute bleach baths
• Limited Sun Exposure
• Moisturizer
• SPF 30 or Higher Suncreen
• Sun Protective Clothing
• Warm Baths or Showers

Trial Overview The study tests whether a preventive skin care regimen can help children undergoing treatment for brain tumors with certain inhibitors. The regimen includes dilute bleach baths, high SPF sunscreen, moisturizers, protective clothing, and limited sun exposure.

Participant Groups

Group I: Preventative Skin Care Routine Experimental Treatment 6 Interventions

Participants will perform a preventative skin care routine that includes daily sun protection, daily gentle skin care and every-other-day dilute bleach baths for the duration of the study. Participants will receive skin examinations and complete a survey about their skin condition at the initial visit when anti-cancer treatment is started, at six weeks after the start of treatment, and at twelve weeks after the start of treatment.

Who Is Running the Clinical Trial?

Dana-Farber Cancer Institute

Lead Sponsor

Trials

1,128

Recruited

382,000+