Cognitive Training for PTSD
(CCTPTSD Trial)
Trial Summary
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your healthcare provider.
What data supports the effectiveness of the treatment Compensatory Cognitive Training (CCT) for PTSD?
Is Compensatory Cognitive Training (CCT) safe for humans?
How is Compensatory Cognitive Training (CCT) different from other treatments for PTSD?
Compensatory Cognitive Training (CCT) is unique because it focuses on improving cognitive functions like memory, attention, and problem-solving, which are often affected in PTSD, especially when combined with traumatic brain injury (TBI). Unlike standard therapies, CCT specifically addresses these cognitive deficits, which can enhance overall treatment outcomes for PTSD.12458
What is the purpose of this trial?
Approximately half a million Veterans receiving services at the VA have Posttraumatic Stress Disorder (PTSD). PTSD is strongly associated with cognitive functioning deficits in areas of concentration, attention, memory, learning, verbal abilities, processing speed, and multitasking. Compensatory Cognitive Training (CCT) is an evidence-based intervention for cognitive problems that is effective in other Veteran populations such as those with a history of traumatic brain injury (TBI), but CCT has not yet been tested in Veterans with PTSD who don't have a history of TBI. The investigators will conduct a pilot randomized controlled trial (RCT) of CCT in Veterans who have been treated for PTSD but continue to have cognitive functioning deficits. The investigators will examine feasibility, acceptability, participant characteristics, and effect size estimates in preparation for a fully-powered RCT of CCT for PTSD-related cognitive functioning deficits.
Research Team
Maya Elin O'Neil, PhD MS
Principal Investigator
VA Portland Health Care System, Portland, OR
Eligibility Criteria
This trial is for English-speaking Veterans with PTSD who've had treatment in the last 2 years and still struggle with cognitive issues like memory, attention, or decision-making. They must have a mental health provider and not suffer from severe psychiatric disorders, substance dependence (recent), major brain injuries, or conditions affecting cognition.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Compensatory Cognitive Training (CCT) or Treatment as Usual (TAU) for cognitive functioning deficits
Follow-up
Participants are monitored for changes in cognitive functioning and quality of life
Treatment Details
Interventions
- Compensatory Cognitive Training (CCT)
- Treatment as Usual (TAU)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor