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Behavioral Intervention

Cognitive Training for PTSD (CCTPTSD Trial)

N/A

Recruiting

Led By Maya Elin O'Neil, PhD MS

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Eligible Veterans must meet DSM-5 criteria for PTSD with evidence-based PTSD treatment participation within the past 2 years

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline to 3 and 6 months

Awards & highlights

CCTPTSD Trial Summary

This trial is testing whether an intervention called compensatory cognitive training (CCT) is effective in improving cognitive functioning in veterans with posttraumatic stress disorder (PTSD).

Who is the study for?

This trial is for English-speaking Veterans with PTSD who've had treatment in the last 2 years and still struggle with cognitive issues like memory, attention, or decision-making. They must have a mental health provider and not suffer from severe psychiatric disorders, substance dependence (recent), major brain injuries, or conditions affecting cognition.Check my eligibility

What is being tested?

The study tests Compensatory Cognitive Training (CCT) against usual care to see if CCT can help veterans with PTSD improve their cognitive skills such as concentration and memory. It's a pilot randomized controlled trial preparing for a larger future study.See study design

What are the potential side effects?

Since this trial involves cognitive training rather than medication, traditional side effects are not expected. However, participants may experience frustration or fatigue during training exercises.

CCTPTSD Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a veteran diagnosed with PTSD and have been in treatment within the last 2 years.

CCTPTSD Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline to 3 and 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline to 3 and 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 3 and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

California Verbal Learning Test (CVLT-II; Delis et al., 2000)

Controlled Oral Word Association Test (Benton, Hamsher, & Sivan, 1983)

Halstead Reitan Trailmaking Test (Trails A & B; Reitan & Wolfson, 1985)

+7 more

Secondary outcome measures

Mini International Neuropsychiatric Interview (MINI; Sheehan et al., 2006)

PTSD Checklist (PCL-5; Weathers et al., 2013)

Patient Health Questionnaire (PHQ-9; Spitzer, Kroenke, & Williams, 1999)

CCTPTSD Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Compensatory Cognitive Training (CCT)Experimental Treatment1 Intervention

Compensatory Cognitive Training draws from the theoretical literature on compensatory strategy training for other cognitively impaired populations (e.g., Huckans et al., 2013; Twamley et al., 2010; Storzbach et al., 2016). It is a rehabilitation model that aims to teach individuals strategies that allow them to work around cognitive deficits. Consistent with this model and the expert recommendations for civilians and Service members with TBI (Cicerone, 2011), manualized CCT treatment provides training in compensatory attention and learning/memory skills, formal problem-solving strategies applied to daily problems, and the use of external aids such as calendar systems and assistive devices to promote completion of daily tasks (Storzbach et al., 2016).

Group II: Treatment as Usual (TAU)Active Control1 Intervention

All TAU participants have an ongoing VA mental health provider and received ongoing mental health care during the course of the study (generally weekly individual or group sessions focusing on evidence-based PTSD treatment).

0 / 1Eligibility criteria met

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Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor

1,610 Previous Clinical Trials

3,305,148 Total Patients Enrolled

Maya Elin O'Neil, PhD MSPrincipal InvestigatorVA Portland Health Care System, Portland, OR

Media Library

Compensatory Cognitive Training (CCT) (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03696225 — N/A

Post-Traumatic Stress Disorder Research Study Groups: Compensatory Cognitive Training (CCT), Treatment as Usual (TAU)

Post-Traumatic Stress Disorder Clinical Trial 2023: Compensatory Cognitive Training (CCT) Highlights & Side Effects. Trial Name: NCT03696225 — N/A

Compensatory Cognitive Training (CCT) (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03696225 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants aged 85 and older being considered for this research endeavor?

"This study requires that participants be within the age range of 18 and 75, as specified in its inclusion criteria."

Answered by AI

Are there still opportunities to participate in this medical experiment?

"Clinicaltrials.gov affirms that this clinical trial is currently recruiting participants, having gone live on March 6th 2019 and last modified on July 12th 2022."

Answered by AI

What is the maximum participant capacity for this trial?

"Affirmative. The entry on clinicaltrials.gov suggests that this medical investigation is currently enrolling participants. It was initially posted in March of 2019 and last updated in July of 2022, with 36 patients required from a single site."

Answered by AI

To whom is enrollment in this research trial available?

"This clinical trial seeks 36 individuals aged between 18 and 75, who have been diagnosed with post traumatic stress disorder (PTSD). To be eligible for recruitment, applicants must fulfill the following criteria: demonstrate DSM-5 compliant PTSD symptoms alongside evidence of recent treatment; possess a personal mental health provider/case manager to coordinate care and provide therapy if necessary; present signs of mild cognitive impairment that interfere with daily activities such as memory issues, difficulties concentrating or completing tasks in school or at work; command proficient English proficiency; read & write adequately enough to offer informed agreement."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD

2019. "Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03696225.

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