Tetracycline for Acne
(T-4 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests an antibiotic that reduces inflammation in patients who still have symptoms after standard Lyme disease treatment. The goal is to see if it can improve symptoms like fatigue and pain. The antibiotic has been shown to reduce both bacterial load and inflammation.
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as antibiotics, immunosuppressive drugs, and those that interact with tetracycline. There is also a one-week washout period (time without taking certain medications) before starting the trial.
Is tetracycline safe for treating acne?
How does the drug tetracycline differ from other acne treatments?
What data supports the effectiveness of the drug Tetracycline for treating acne?
Who Is on the Research Team?
John N. Aucott, MD
Principal Investigator
Johns Hopkins University
Are You a Good Fit for This Trial?
Adults aged 18-80 with a documented history of Lyme disease onset within the last 5 years and symptoms starting within a year. Participants must have persistent symptoms that affect daily life, have been treated with antibiotics for Lyme disease, and score at least 4.0 on the Fatigue Severity Scale.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either tetracycline or placebo for 3 months
Crossover Treatment
Participants switch to the alternate treatment for another 3 months with blind maintained
Follow-up
Participants are monitored for the return of symptoms and overall tolerability
What Are the Treatments Tested in This Trial?
Interventions
- Tetracycline
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
Steve and Alexandra Cohen Foundation
Collaborator