Tetracycline First for Lyme Disease

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Lyme Disease+3 More
Tetracycline 500 Mg - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether a 3-month course of tetracycline is better than a 3-month course of placebo at improving acne. Patients will be randomly assigned to one of the two treatments and will not know which they are receiving. The study will last for 6 months.

Eligible Conditions
  • Lyme Disease
  • Post-Lyme Disease Syndrome

Treatment Effectiveness

Study Objectives

3 Primary · 1 Secondary · Reporting Duration: 36 months

36 months
Fatigue as assessed by the Fatigue Severity Scale
Participant Retention
Tolerability as assessed by number of side effects
Tolerability as assessed by severity of side effects

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Tetracycline First
1 of 2
Placebo First
1 of 2

Active Control

Non-Treatment Group

60 Total Participants · 2 Treatment Groups

Primary Treatment: Tetracycline First · Has Placebo Group · Phase 2

Placebo FirstPlaceboComparator Group · 2 Interventions: Tetracycline 500 Mg, Placebo · Intervention Types: Drug, Other
Tetracycline FirstActiveComparator Group · 2 Interventions: Tetracycline 500 Mg, Placebo · Intervention Types: Drug, Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 36 months

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,057 Previous Clinical Trials
31,003,234 Total Patients Enrolled
2 Trials studying Lyme Disease
120 Patients Enrolled for Lyme Disease
John N. Aucott, MDPrincipal InvestigatorJohns Hopkins University

Eligibility Criteria

Age 18+ · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have previously been treated with at least one course of antibiotic therapy for PTLD.
You have moderate or greater fatigue severity.
You have persistent symptoms in at least the last month.
Patient has a history of definite or probable Lyme disease with onset in the last 5 years, with symptoms developing within 1 year of Lyme onset.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 13th, 2021

Last Reviewed: November 8th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

Who else is applying?

What state do they live in?
North Carolina100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Johns Hopkins Lyme Disease Research Center100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%