Browse 88 Rheumatoid Arthritis Medical Studies Across 324 Cities
15 Phase 3 Trial · 1138 Rheumatoid Arthritis Clinics
What Are Rheumatoid Arthritis Clinical Trials?
Rheumatoid Arthritis clinical trials determine whether new treatments for Rheumatoid Arthritis are effective and well tolerated by patients.
The measurement of the success of a trial depends on an improvement in the patient's overall well-being and effective disease management. There must be an initial patient diagnosis and an endpoint to measure improvement from clinical trials. Rheumatoid Arthritis Severity Scale (RASS) Index measures symptoms based on disease activity, functional impairment, and physical damage.
Recent clinical trials aim to find a new-generation medication with fewer negative side effects than autoimmune suppressant treatments, as well as alleviation of symptoms, minimization of damage to joints, prolonged periods of remission, and increased joint mobility.
Why Is Rheumatoid Arthritis Being Studied Through Clinical Trials?
Rheumatoid Arthritis is an autoimmune disease resulting in painful, inflamed joints which may become deformed over time. An autoimmune disease is defined by the body attacking its healthy cells, and in the case of Rheumatoid Arthritis, the body attacks healthy tissue.
Rheumatoid Arthritis first manifests in smaller joints, such as fingers and toes, and gradually progresses to larger ones, like knees, elbows, hips, ankles, and shoulders. The disease has stages of flare-ups and remission. Inflammation generally appears on both sides of the body.
Not only does Rheumatoid Arthritis affect joints, but it may also cause other health concerns and damage to the heart, lungs, eyes, kidneys, nerves, and nerve tissues.
What Are The Types of Treatments Available For Rheumatoid Arthritis?
Various treatments are available for Rheumatoid Arthritis ranging from over-the-counter medication to surgery in extreme cases. The nature of the treatment depends on the severity and impact of the disease.
Surgery is an option when Rheumatoid Arthritis causes severe pain and significantly reduces mobility. Typical surgeries include the removal of the inflamed lining of the joint (Synovectomy), tendon repair, fusing joints, and joint replacement.
What Are Some Recent Breakthrough Clinical Trials For Rheumatoid Arthritis?
2022: Janus Kinase (JAK) inhibitors, Rinvoq, Olumiant, and Xeljanz, treat Rheumatoid Arthritis by blocking Janus Kinase enzymes which provide pathways for pro-inflammatory cytokines to be released into the body. These drugs are DMARDs and assist in slowing the long-term degeneration effects of the disease.
2022: Otilimab is a new market injectable and a monoclonal antibody that suppresses the inflammatory cytokine GM-CSF. The significance of this breakthrough clinical trial is that Otilimab treats both inflammation and pain effectively, and patients do not need to add pain medication to their treatment regime.
Who Are Some Of The Key Opinion Leaders In Psoriasis Clinical Trial Research?
Dr. Philip Mease has an internal medicine and fellowship in rheumatology at the University of Washington and is a Clinical Professor of Medicine. He leads rheumatology research at the Swedish Medical Center and has written 300 journal articles. He is a well-respected international speaker addressing medical conferences on rheumatology and dermatology.
Amye L. Leong, MBA, is the first person from the rheumatology community to receive the 2001 Presidents Service Award, the most prestigious community service award in America. Her credentials include Advisor to the US Food and Drug Administration, Patient-Centered Outcomes Research Institute, and Agency for Health Research and Quality. Her Patient Engagement Research has received 34 citations in journals reviewed by her peers.