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Monoclonal Antibodies
LY3462817 for Rheumatoid Arthritis
Phase 2
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12
Summary
This trial is testing a new medication called LY3462817 to see if it is safe and effective for people with moderately to severely active rheumatoid arthritis. The drug likely works by reducing inflammation and pain.
Eligible Conditions
- Rheumatoid Arthritis
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ week 12
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 12
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change From Baseline on the Disease Activity Score Modified to Include the 28 Diarthrodial Joint Count-High-Sensitivity C-Reactive Protein (DAS28-hsCRP)
Secondary study objectives
Change From Baseline for Mean Clinical Disease Activity Index (CDAI)
Change From Baseline for Mean Simplified Disease Activity Index (SDAI)
Change From Baseline in Mental Component Score (MCS), Physical Component Score (PCS) of the Medical Outcomes Study 36-Item Short Form Health Survey Version 2 Acute (SF-36v2 Acute)
+4 moreSide effects data
From 2022 Phase 2 trial • 98 Patients • NCT046342538%
Nausea
2%
Osteoarthritis
2%
Pruritus
2%
Nasopharyngitis
2%
Dyslipidaemia
2%
Back pain
2%
Hypothyroidism
2%
Rhinitis
2%
Upper respiratory tract infection
2%
Vomiting
2%
Arthralgia
2%
Covid-19
2%
Hyperglycaemia
2%
Headache
2%
Hypoaesthesia
2%
Pyrexia
2%
Upper respiratory tract infection bacterial
2%
Urinary tract infection
2%
Vulvovaginal candidiasis
2%
Diabetes mellitus
2%
Diarrhoea
2%
Dermatitis atopic
100%
80%
60%
40%
20%
0%
Study treatment Arm
LY3462817 700 mg
Placebo
LY3462817 300 mg
Trial Design
3Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3462817 700 mgExperimental Treatment1 Intervention
Participants received IV infusion of 700 mg LY3462817 solution.
Group II: LY3462817 300 mgExperimental Treatment1 Intervention
Participants received Intravenous (IV) infusion of 300 mg LY3462817 solution.
Group III: PlaceboPlacebo Group1 Intervention
Participants received IV infusion of 0.9% sodium chloride solution (Placebo).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3462817
2021
Completed Phase 2
~100
Find a Location
Who is running the clinical trial?
Eli Lilly and CompanyLead Sponsor
2,654 Previous Clinical Trials
3,224,606 Total Patients Enrolled
28 Trials studying Rheumatoid Arthritis
17,080 Patients Enrolled for Rheumatoid Arthritis
Study DirectorEli Lilly and Company
1,378 Previous Clinical Trials
423,490 Total Patients Enrolled
17 Trials studying Rheumatoid Arthritis
13,445 Patients Enrolled for Rheumatoid Arthritis
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