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Beta Blocker

Behavioral + Propranolol for Misophonia (Miso Prop Trial)

Q: Are individuals aged 55 and over being accepted into the trial?

This medical trial is seeking volunteers aged 18 and above, yet younger than 55.

Q: Who can participate in this medical experiment?

Prerequisites for this medical trial include having misophonia and being aged between 18 to 55. In total, approximately 150 participants are needed.

Q: Is the recruitment process still open for this investigation?

A review of clinicaltrials.gov reveals that this particular medical trial, which launched on June 2nd 2023 and was last updated two weeks later, is not presently enrolling patients. Nonetheless, there are still other trials seeking participants.

Phase < 1

Recruiting

Led By Daniela Schiller, PhD

Research Sponsored by Icahn School of Medicine at Mount Sinai

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and after 6 hours

Awards & highlights

Miso Prop Trial Summary

This trial aims to help treat misophonia using behavioural, computational and neural analyses to understand its underlying mechanisms and disrupt memory reconsolidation with propranolol.

Who is the study for?

This trial is for adults aged 18-55 with misophonia, which means they have strong negative reactions to certain sounds. Participants must speak English fluently and not be pregnant, breastfeeding, or have a pulse outside of the range 55-100 bpm. They should not take specific medications that interact with propranolol, have high or low blood pressure issues, cardiovascular illnesses, respiratory diseases like COPD, diabetes mellitus, CNS diseases or recent drug abuse.Check my eligibility

What is being tested?

The study tests if interfering with memory reconsolidation using propranolol can reduce aversive reactions in misophonia when reminded of triggering sounds. It compares this approach against placebo and counterconditioning techniques through behavioral and neural analyses.See study design

What are the potential side effects?

Propranolol may cause side effects such as dizziness, fatigue, trouble sleeping, stomach cramps and nausea. In some cases it might also affect heart rate and blood pressure or worsen breathing problems.

Miso Prop Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and after 6 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and after 6 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and after 6 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in average Galvanic skin response based on deflections of a wave

Secondary outcome measures

Change in Approach-Avoidance test

Change in Average Galvanic skin response based on deflections of a wave

Change in average heart rate

+1 more

Miso Prop Trial Design

5Treatment groups

Experimental Treatment

Placebo Group

Group I: No memory reminder followed by counterconditioningExperimental Treatment1 Intervention

This arm aims to have 30 participants with a behavioral manipulation. They will not receive a reminder to reactivate their memory of a misophonia trigger and then undergo counterconditioning.

Group II: No memory reminder followed by Propranolol HydrochlorideExperimental Treatment1 Intervention

This arm aims to have 30 participants with a pharmacological manipulation. They will not receive a reminder to reactivate their memory of a misophonia sound and only receive a propranolol hydrochloride tablet.

Group III: Memory reminder followed by counterconditioningExperimental Treatment2 Interventions

This arm aims to have 30 participants with a behavioral manipulation. They will receive a reminder to reactivate their memory of a misophonia trigger and then will undergo counterconditioning.

Group IV: Memory Reminder followed by Propranolol HydrochlorideExperimental Treatment2 Interventions

This arm aims to have 30 participants with a pharmacological manipulation. They will receive a reminder to reactivate their memory of a misophonia trigger followed by ingestion of a propranolol hydrochloride tablet.

Group V: Memory reminder followed by PlaceboPlacebo Group2 Interventions

This arm aims to have 30 participants with a pharmacological manipulation. They will receive a reminder to reactivate their memory of a misophonia trigger followed by ingestion of a placebo tablet.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Reminder

2022

N/A

~311170

Counterconditioning

2018

N/A

~140

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor

862 Previous Clinical Trials

525,476 Total Patients Enrolled

Daniela Schiller, PhDPrincipal InvestigatorIcahn School of Medicine at Mount Sinai

James Murrough, MD, PhDPrincipal InvestigatorIcahn School of Medicine at Mount Sinai

5 Previous Clinical Trials

224 Total Patients Enrolled

Media Library

Propranolol Hydrochloride (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT05928689 — Phase < 1

Misophonia Research Study Groups: No memory reminder followed by Propranolol Hydrochloride, Memory reminder followed by Placebo, Memory Reminder followed by Propranolol Hydrochloride, No memory reminder followed by counterconditioning, Memory reminder followed by counterconditioning

Misophonia Clinical Trial 2023: Propranolol Hydrochloride Highlights & Side Effects. Trial Name: NCT05928689 — Phase < 1

Propranolol Hydrochloride (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05928689 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 55 and over being accepted into the trial?

"This medical trial is seeking volunteers aged 18 and above, yet younger than 55."

Answered by AI

Who can participate in this medical experiment?

"Prerequisites for this medical trial include having misophonia and being aged between 18 to 55. In total, approximately 150 participants are needed."

Answered by AI

Is the recruitment process still open for this investigation?

"A review of clinicaltrials.gov reveals that this particular medical trial, which launched on June 2nd 2023 and was last updated two weeks later, is not presently enrolling patients. Nonetheless, there are still other trials seeking participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Behavioral and Pharmacological Reconsolidation Interference in Misophonia

Daniela Schiller 2023. "Behavioral and Pharmacological Reconsolidation Interference in Misophonia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05928689.