Esophageal Cancer Clinical Trials 2022

Esophageal Cancer studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect esophageal cancer clinical trial in 2022.

Filter Clinical TrialsFilter Clinical Trials

LOCATION

Anywhere

FILTER TRIALS

No feeding tube placed

Patients diagnosed with esophageal cancer have difficulty eating, as the food pipe becomes obstructed by the cancer. This may impair the ability for the patient to receive appropriate calorie intake, especially during administration of chemotherapy and radiation therapy given prior to surg…

This phase I trial tests the safety, side effects studies chemotherapy followed by chemotherapy at the same time as radiation therapy (chemoradiation) before surgery (neoadjuvant) in treating patients with stage gastric (stomach) or gastroesophageal junction cancer . Chemotherapy drugs, su…

This phase I trial tests the safety and tolerability of an experimental personalized vaccine when given by itself and with pembrolizumab in treating patients with solid tumor cancers that have spread to other places in the body (advanced). The experimental vaccine is designed target certai…

Based on preclinical data, the investigators hypothesize that IRAK4 inhibition cripples tumor-intrinsic survival signaling and effectively overcomes the desmoplastic and immune-suppressive TME to render chemo- and immunotherapies effective in gastrointestinal (GI) malignancy. Therefore, th…

The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.

This study is being done to find out if zanidatamab, when given with chemotherapy plus or minus tislelizumab, is safe and works better than trastuzumab given with chemotherapy. The patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esopha…

The main objective of Part 1 is to evaluate the safety and tolerability of bemarituzumab plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) and nivolumab. The main objective Part 2 is to compare efficacy of bemarituzumab plus mFOLFOX6 and nivolumab to placebo plus mFOLFOX6 and ni…

The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin and 5-fluorouracil (5-FU) (mFOLFOX6) to placebo plus mFOLFOX6 as assessed by overall survival (OS).

This study is evaluating whether the use of a blood thinner or saline solution in the needle being used to sample your abdominal tumor will affect the amount and quality of tissue obtained by EUS-FNB.

This study is evaluating whether a combination of pembrolizumab and lenvatinib is safe and effective in treating patients with gastroesophageal adenocarcinoma that has spread to other places in the body (advanced

Pembrolizumab/Vibostolimab Co-Formulation

This study is evaluating whether a combination of a drug and a light therapy is better than a drug alone in treating cancer.

A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.

This study is evaluating whether a new drug called ELU001 can be used to treat cancer.

The purpose of this study is to assess the efficacy and safety of pembrolizumab plus lenvatinib plus chemotherapy compared with pembrolizumab plus chemotherapy as first-line intervention in participants with metastatic esophageal carcinoma The primary hypotheses are that pembrolizumab plu…

This study is evaluating whether a combination of chemoradiation and pembrolizumab followed by pembrolizumab and lenvatinib before surgery may kill more tumor cells.

Biospecimen Collection - blood and tissue sample collection

This study is evaluating whether a personalized ctDNA test can be used to guide treatment for patients with gastrointestinal cancer with peritoneal carcinomatosis.

This study is evaluating whether virtual reality can help people with cancer pain.

This study is evaluating whether a drug called CBX-12 may be safe and effective for individuals with advanced or metastatic cancer.

This study is evaluating whether a drug may help treat solid tumors.

This is a Phase I trial evaluating the safety of personalized radiation therapy based on levels of hypoxia identified on FMISO-PET and MRI. All patients will receive a baseline FMISO PET and MRI to identify levels of hypoxia. Patients with tumor hypoxia will receive a higher dose of radiat…

This study is evaluating whether avapritinib can help treat malignant solid tumors.

The purpose of this study is to find out whether combining nivolumab, FOLFOX, and regorafenib may be a safe and effective treatment for people who have HER2-negative metastatic esophagogastric cancer. Nivolumab is an antibody, like the proteins made by the immune system to protect the bod…

Autologous genetically modified ADP-A2M4CD8 cells

This study is evaluating whether a new type of immune therapy can help treat esophageal cancer.

Trastuzumab Deruxtecan

This study is evaluating whether a combination of ceralasertib and trastuzumab deruxtecan is better than trastuzumab deruxtecan alone for treating patients with solid tumors that have a change (mutation) in the HER2 gene or protein and have spread

This study is evaluating whether a drug may help treat cancer.

This study is evaluating whether a drug called BNT141 can be safely given to patients with cancer.

This study is evaluating whether propranolol may help reduce the side effects of chemotherapy for individuals with esophageal cancer.

This trial will look at a drug called SGN-STNV to find out whether it is safe for patients with solid tumors. It will study SGN-STNV to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study how well SGN-STNV works to treat s…

Quality-of-Life Assessment

This study is evaluating whether the combination of two drugs may help treat gastric or gastroesophageal junction cancer.

In this research study, is studying how Liposomal Irinotecan in combination with the standard of care interventions FOLFOX, carboplatin paclitaxel, and radiation therapy affect gastroesophageal junction or esophagogastric cancer This research study involves the following study interventio…

Hafnium Oxide-containing Nanoparticles NBTXR3

This study is evaluating whether a drug called NBTXR3 can be safely given with radiation therapy and chemotherapy for esophageal cancer.

The main purposes of the dose escalation part of this study is to determine the following in participants with gastric or gastro-esophageal junction (GEJ) or esophageal adenocarcinoma (EAC): Safety and tolerability of NT-I7 in combination with nivolumab Maximum Tolerated Dose (MTD) and/or…

This study is evaluating whether prehabilitation can improve outcomes for people with esophageal cancer.

This clinical trial is evaluating a drug called BT8009 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression or in participants with advanced solid tumor malignancies having renal insufficiency. The main goals of this study …

This study is evaluating whether a drug called BAY 1895344 can be safely given in combination with chemotherapy drugs.

This study is evaluating whether a combination of immunotherapy and chemotherapy may help treat gastroesophageal cancer.

This study is evaluating whether a mobile application may help people prepare for end of life care.

Trifluridine and Tipiracil Hydrochloride

This study is evaluating the safety of talazoparib when given together with trifluridine/tipiracil for the treatment of patients with colorectal or gastroesophageal cancer that has spread to nearby tissue or

This study is evaluating whether a combination of two drugs may help clear cancerous DNA from the body.

This study is evaluating whether a combination of oral cryotherapy, acupressure, and acupuncture may help decrease chemotherapy-induced peripheral neuropathy in patients with gastrointestinal cancer.

This study is being done to see if tucatinib with trastuzumab, ramucirumab and paclitaxel works better than ramucirumab and paclitaxel to treat HER2-positive (HER2+) cancer of the gut (stomach or gastroesophageal cancer). This study will also look at what side effects happen when participa…

This study is evaluating whether a new monitoring system can help reduce the side effects of chemotherapy.

Sentinel Lymph Node (SLN) mapping

This study is evaluating whether a new imaging technique can help surgeons identify the lymph nodes that are most likely to have cancer.

This study is evaluating the side effects of a new drug called OBP-301 when given together with chemotherapy and radiation therapy in treating patients with esophageal or gastroesophageal cancer.

This study is evaluating whether a combination of two drugs may help treat stomach cancer.

This study is evaluating whether a combination of a new device and a lab developed test may help detect esophageal cancer.

This study is evaluating whether AMG 910 is safe and effective for treating cancer.

iGuide 2 Intervention (Tailored/Targeted)

This study is evaluating whether a new approach to treating cancer may improve the health of cancer survivors.

Background: In published studies, complete response (CR) to chemoradiation occurs in only 25-30% of patients with locally advanced esophageal cancer. Liquid nitrogen spray cryotherapy (LNSC) is postulated to stimulate an anti-tumor immune response. In a preliminary study, the investigators…

This study is evaluating whether the addition of radiation therapy to chemotherapy may help treat patients with esophageal and gastric cancer.

Radiation Therapy (RT)

This study is evaluating whether radiation therapy may help slow or stop the growth of cancer that has spread to other parts of the body.

This study is evaluating whether paclitaxel may be an effective treatment for gastric or gastroesophageal cancer.

The purpose of this study is to assess the efficacy and safety of treatment with definitive chemoradiotherapy (dCRT) + pembrolizumab (MK-3475) compared to treatment with dCRT + placebo with respect to Overall Survival (OS) and Event-free Survival (EFS) in: participants with esophageal squ…

This study is evaluating whether a drug called VE800 can be safely combined with a drug called Nivolumab to treat cancer.

This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (standard of care cancer treatment) for participants with advanced esophageal cancer, glioblastoma, prostate can…

This study is evaluating whether a drug may help treat cancer.

Gallium Ga 68-labeled PSMA-11

This phase I trial studies a new imaging technique called FAPi PET/CT to determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulate in normal and cancer tissues in patients with non-prostate cancer. The research team also want to know whether what they see on PET/CT imag…

Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE

This phase IIA trial investigates the side effects of Ad5.F35-hGCC-PADRE vaccine and to see how well it works in treating patients with gastrointestinal adenocarcinoma. Ad5.F35-hGCC-PADRE vaccine may help to train the patient's own immune system to identify and kill tumor cells and prevent…

This study is evaluating whether a combination of chemotherapy drugs may help treat patients with esophageal or gastroesophageal junction adenocarcinoma.

Home-based cardiac rehabilitation

This study is evaluating whether aerobic exercise may help reduce the risk of heart disease in patients with lung or esophageal cancer.

MOS Social Support Measure

This study is evaluating whether a new radiation therapy regimen may help improve local control of esophageal cancer.

Autologous genetically modified ADP-A2M4CD8 cells

This study is evaluating whether a type of white blood cell may help treat cancer.

Nutritional Supplementation

This study is evaluating whether a nutritional supplement may help reduce complications in patients with esophageal cancer.

Sequential FLOT followed by chemoradiation

This study is evaluating whether a combination of chemotherapy and radiation may help treat esophageal cancer.

This study is evaluating whether a drug called nivolumab may help treat pancreatic cancer.

This study is evaluating whether a medication used to treat fungal infections may help improve the effectiveness of radiation therapy for esophageal cancer.

This study is evaluating whether a combination of two drugs may help treat patients with advanced solid tumors.

This study is evaluating whether a combination of drugs may help treat advanced gastric, gastroesophageal, and esophageal adenocarcinoma. original:

This study is evaluating whether a combination of two drugs may help treat head and neck cancer.

Informational Intervention

This study is evaluating whether a financial navigation intervention may help improve financial and clinical outcomes in patients with newly diagnosed gastric or gastroesophageal junction adenocarcinoma.

This study is evaluating whether zinc may help to improve quality of life in patients with gastrointestinal cancer.

This study is evaluating whether a type of radiation therapy may be more effective than another type of radiation therapy in treating esophageal cancer.

This study is evaluating whether a combination of chemotherapy and immunotherapy may be more effective than chemotherapy alone for treating esophageal or gastroesophageal cancer.

This study is evaluating whether a drug may help treat stomach cancer.

This study is evaluating whether a combination of immunotherapy and chemotherapy may be more effective than chemotherapy alone for treating patients with gastric cancer.

This study is evaluating whether a combination of two drugs may help treat gastric and gastroesophageal junction cancer.

This study is evaluating whether a combination of two drugs may help treat gastric cancer.

This study is evaluating whether a combination of immunotherapy and chemotherapy may be more effective than chemotherapy alone in treating esophageal and gastroesophageal junction adenocarcinoma

Fine-Needle Aspiration

This study is evaluating whether an ultrasound with a contrast agent may help identify sentinel lymph nodes in individuals with esophageal cancer.

VMD-928 300 mg Tablets or 100 mg Capsules

This study is evaluating whether a drug may help treat cancer.

This study is evaluating whether a combination of two treatments may help treat cancer.

This study is evaluating whether a combination of two drugs may be more effective than either drug alone for individuals with advanced gastric cancer.

Avelumab combined with Chemoradiation

This is a 2 part Phase I/II clinical trial evaluating the safety, tolerability and efficacy of avelumab in combination with chemoradiation in patients with resectable esophageal and gastroesophageal cancer. Part 1: This is the run-in phase of the trial. This portion will determine the saf…

Patient-Reported Outcome Measures

This study is evaluating whether proton therapy may be as effective as photon therapy for treating esophagus cancer.

Toripalimab, Recombinant Humanized anti-PD-1 Monoclonal Antibody

The primary objective is to assess the safety and tolerability of Toripalimab in subjects with various advanced malignancies and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of Toripalimab, 2) evaluate antitumor ac…

Oxaliplatin+Capecitabine+Pembrolizumab

This study is evaluating whether a combination of drugs can improve the survival of people with esophageal cancer.

Leucovorin 400 mg/m^2

This study is evaluating whether a combination of chemotherapy drugs may help treat advanced stomach cancer.

This study is evaluating whether a combination of immunotherapy drugs may help treat patients with advanced cancer.

trūFreeze® System spray cryotherapy

This study is evaluating whether a cryotherapy device can be used to treat esophageal cancer.

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Lung cancer is the leading cause of cancer-related death in the United States. Most people with lung cancer are already in the advanced stages of the disease by the time they see a doctor. Researchers w…

This study is evaluating whether a drug called pembrolizumab can improve survival and reduce side effects for people with esophageal cancer.

This study is evaluating whether a health care coach can help reduce acute care use and cost in people with cancer.