fluorouracil for Adenocarcinoma
A Phase 3 Efficacy, Safety and Tolerability Study of Zolbetuximab (Experimental Drug) Plus mFOLFOX6 Chemotherapy Compared to Placebo Plus mFOLFOX6 as Treatment for Gastric and Gastroesophageal Junction (GEJ) Cancer
See full descriptionAbout the trial for Adenocarcinoma
Treatment Groups
This trial involves 2 different treatments. Fluorouracil is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether fluorouracil will improve 1 primary outcome and 15 secondary outcomes in patients with Adenocarcinoma. Measurement will happen over the course of Up to 13 months.
Patient Q & A Section
What are the signs of adenocarcinoma?
Adenocarcinoma of the lung can affect any part of the chest, but the trachea and large bronchi are more likely to be involved. A cough that is more severe in the morning usually indicates the presence of an adenocarcinoma. Chest pain may be caused by bronchitis or pneumonia, so it is also important to investigate this condition. Because adenocarcinoma can often be difficult to diagnose, we must determine the location by performing a CT scan of the chest and then the chest X-ray.
How many people get adenocarcinoma a year in the United States?
Around 65,000 cases of invasive adenocarcinoma of the pancreas are diagnosed each year in the United States. Although this is a rare form of cancer that is generally confined to the pancreas, in the United States the incidence continues to rise faster than any other form of adenocarcinoma, and is likely to increase continuously in the future. Pancreas ductal adenocarcinoma was the most common form of pancreatic carcinoma between 1973 and 1995.
What causes adenocarcinoma?
Adenocarcinoma is a complex, multiple interacting disease, as tumors have multiple mechanisms for invasiveness. A better understanding of what makes a tumor invasive may help in finding new approaches to prevention and treatment of this disease.
What is adenocarcinoma?
Adenocarcinoma accounts for 80 percent of all cancer cases reported to the New York State Cancer Registry. Although the incidence rate is nearly twice as high for women as for men, adenocarcinomas of the lung form about the same amount of disease in men and women. Lung adenocarcinomas form the vast majority of all adenocarcinomas in Caucasians and most adenocarcinomas in women in the United States. Adenocarcinoma tends to progress more slowly than the other main subtype of lung cancer, squamous cell carcinoma.
What are common treatments for adenocarcinoma?
Common treatments for adenocarcinoma use surgery, chemotherapy, radiation and targeted therapy. There are no cures for adenocarcinoma, so treatment is focused on symptom management and is highly dependent on the specific patient.
Can adenocarcinoma be cured?
Adenocarcinomas have a relatively short survival (<5 years). Therefore, in patients with a poor performance status or a limited life span, treatment options should be considered carefully.
What is the primary cause of adenocarcinoma?
The primary cause of the adenocarcinoma of the esophagus is not known. It is most likely a combination of factors, including smoking, reflux, dietary factors, and physical trauma to the esophagus.
What is the survival rate for adenocarcinoma?
Adenocarcinomas of the gastric fundus have an excellent prognosis in spite of their high degree of malignancy. However, advanced disease has a poor prognosis due to an extremely high rate of peritoneal and pulmonary metastasis.
What is the latest research for adenocarcinoma?
[The two histologic subtypes of adenocarcinoma, ocular and nonocular adenocarcinoma, do not have an obvious difference in treatment, prognosis, or life expectancy (http://www.withpower.com/clinical-trials/adenocarcinoma/index.htm).] While this makes sense, they are not entirely similar. Ocular adenocarcinomas are typically more aggressive and have shorter survival times. Nonocular adenocarcinoma is associated with longer survival times and treatment of choice in ocular adenocarcinoma.
Have there been any new discoveries for treating adenocarcinoma?
Adenocarcinoma of the large intestine is a unique disease with some interesting characteristics. To date our understanding of the underlying molecular mechanisms has been rather limited. Some studies have suggested the identification of specific gene mutations as an early predictor of disease outcome, for example with respect to response to cytotoxic drugs. More data are required to help predict the disease process and refine our current treatment algorithms.
Is fluorouracil typically used in combination with any other treatments?
The main reason for administration of fluorouracil is that the majority of patients do not know whether a potential therapy contains fluorouracil and therefore do not receive or refuse chemotherapy.
Is fluorouracil safe for people?
In this multicenter study of elderly patients with advanced adenocarcinoma, only one serious adverse event occurred in each of the 13,065 patients treated (0.1%). One-year survival was comparable to results obtained with chemotherapy in the general population. Based on these data, the authors recommend routine use of fluorouracil despite the presence of comorbidities and advanced age in this group of elderly patients with incurable cancer.