Questionnaires for Cancer of Esophagus

Waitlist Available · 18+ · All Sexes · Houston, TX

This study is evaluating whether proton-beam therapy is as effective as intensity modulated radiation therapy in treating esophageal cancer.

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About the trial for Cancer of Esophagus

Eligible Conditions
Esophageal Neoplasms Malignant · Esophageal Neoplasms

Treatment Groups

This trial involves 2 different treatments. Questionnaires is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Proton Beam Therapy (PBT)
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Intensity Modulated Radiation Therapy (IMRT)

About The Treatment

First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 2


This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Age >/= 18
Performance status of Karnofsky Performance Scale (KPS) >/= 60 or Eastern Cooperative Oncology Group (ECOG) = 0, 1, or 2.
Prior thoracic radiation allowable only if there is minimal to no overlap with the treatment area estimated at the time of consultation.
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 12 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 12 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Questionnaires will improve 2 primary outcomes in patients with Cancer of Esophagus. Measurement will happen over the course of 6 weeks after radiation therapy.

Progression-Free Survival (PFS)
Defined from the time of enrollment to the date of death or any recurrence. The progression-free survival (PFS) time distribution will be estimated in each treatment arm using the Kaplan-Meier method.
Total Toxicity Burden (TTB)
TTB defined from the time of randomization to 12 months after randomization. Total toxicity burden (TTB) is computed as a composite score from serious adverse events (SAEs) and, among patients who undergo surgery, postoperative complications (POCs).

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for cancer of esophagus?

There were no common treatments mentioned in the literature for the treatment of cancer of esophagus that we could apply to patients in our clinic.

Anonymous Patient Answer

What is cancer of esophagus?

Cancers of esophagus are rare in adults. The average age of death from [esophageal cancer]( is about 61 years of age. Esophageal cancer is caused by a number of different processes. A small proportion of esophageal cancers are related to smoking. Other factors include alcohol, tea, coffee, chewing betelquid, nonalcoholic fatty liver disease, dietary factors, obesity, diabetes, and viral infections such as human papillomavirus and human T-lymphotropic virus. Esophageal cancer is highly debilitating due to the inability to eliminate food from the stomachs.

Anonymous Patient Answer

What are the signs of cancer of esophagus?

  1. Coughing up blood is a common symptom of esophageal cancer.\n2. Painful or bloody urination in men may indicate esophageal cancer.\n3. Constipation may indicate esophageal cancer.\n4. Pain on or just under the chest bone indicates esophageal cancer.\n5. Any lump in the neck could be an esophageal cancer.\n6. White patches on the tongue may be an esophageal cancer.
Anonymous Patient Answer

Can cancer of esophagus be cured?

In the treatment of cancer of the upper gastrointestinal tract, esophagectomy has a better oncological outcome when employed as an alternative treatment in the presence of a malignant tumor. Esophagectomy can be performed in patients with curable disease in whom conventional radiotherapy or chemotherapy has failed, and it may therefore be considered a potential treatment option.

Anonymous Patient Answer

What causes cancer of esophagus?

The main causes of cancer of the esophagus are tobacco, alcohol, and acid reflux from the stomach. This cancer can be a result of tobacco habits, even if these habits seem unnoticeable; many patients do not know they have a gastric tumor. The most common symptom is, of course, the difficulty in swallowing solid foods. Diagnosis is made first by a combination of symptoms, a physical examination, and a history taken from the patient, with special attention to gastroesophageal reflux.

Anonymous Patient Answer

How many people get cancer of esophagus a year in the United States?

About 8,800 people are diagnosed with cancer of the esophagus a year. Esophageal adenocarcinoma is the main form found in this group. The mortality from this disease is much higher than that from the other forms of cancer with the overall mortality in the United States being 28.8 percent.

Anonymous Patient Answer

What is the latest research for cancer of esophagus?

Patients and caregivers are eager to know about new advances in treatment of this disease. Many research-based studies have demonstrated that people with cancer of the esophagus are significantly more likely to die sooner than the general population, but some new treatments have shown promise. To help guide you in choosing the best treatment, follow your doctor's advice, as knowing more is the best way to determine your treatment options. There is also a link between esophageal cancer and Barrett's esophagus, but this does not mean that patients with Barrett's should not bother testing out esophageal cancer screening if their doctor is worried about the possibility of cancer.

Anonymous Patient Answer

How serious can cancer of esophagus be?

The condition of most patients with [esophageal cancer]( was localized at diagnosis. The disease spread to regional lymph nodes a majority of the time (71%). Localized cancer in the resected specimen was more common in patients with T3 and T4 disease than in patients with disease limited to the primary site (74% vs. 33%, respectively; p = 0.04). However, disease extending beyond resection margins was found in 25% of patients with regional lymph node involvement. Survival after treatment for esophageal cancer was good.

Anonymous Patient Answer

Have there been any new discoveries for treating cancer of esophagus?

The new technologies like chemoradiation, targeted therapy, and immunotha-pheresis should help in treatment of esophageal cancer; however, the new advancements cannot replace traditional techniques like surgery and radiation therapy.

Anonymous Patient Answer

Is questionnaires typically used in combination with any other treatments?

The present study shows that a structured interview questionnaire can be used in combination with another treatment such as radiotherapy to assess the distress caused by the treatment and the need for any future change in the treatment. The use of the questionnaire is recommended because of the simplicity, ease of use and the quick results.

Anonymous Patient Answer

Does questionnaires improve quality of life for those with cancer of esophagus?

A short questionnaire can be used to aid patient planning for radiotherapy and is a welcome addition to the cancer care team. If validated, the study outcomes could be widely disseminated.

Anonymous Patient Answer

How quickly does cancer of esophagus spread?

Cancer of esophagus is a rapidly growing life-threatening disease, and the 5-year survival is < 10%. Patients with node-positive [esophageal cancer]( and a bulky tumor have a worse prognosis. The number of lymph node dissection is an important predictor of the survival in esophageal cancer.

Anonymous Patient Answer
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