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Opioids + Benzodiazepines for Substance Abuse (MAP Trial)
MAP Trial Summary
This trial will study the effects of opioids and benzodiazepines on cognition, emotions, and behavior.
MAP Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.MAP Trial Design
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Who is running the clinical trial?
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- I have been prescribed benzodiazepines or opioids in the past month.I have used opioids or sedatives in the past 5 years and may currently have a mild to moderate addiction to them.I have used opioids or sedatives in the last 10 years, for any reason.I have been diagnosed with psychosis, bipolar disorder, or severe depression.I have a condition affecting my nervous, heart, lung, or other body systems.I am not pregnant, breastfeeding, or if sexually active, I use birth control.I am currently taking methadone, buprenorphine, or naltrexone.I haven't taken any forbidden medications in the last 30 days.
- Group 1: Placebo drug
- Group 2: Morphine alone
- Group 3: Alprazolam alone
- Group 4: Morphine then alprazolam
- Group 5: Alprazolam then morphine
- Group 6: Morphine+alprazolam simultaneously
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Do both Alprazolam and morphine have FDA approval?
"Alprazolam then morphine scored a 2 for safety. This is because, although there are Phase 2 trials underway testing its efficacy, currently there is only data supporting its safety."
Are there still available positions for research volunteers?
"Indeed, this is an ongoing study that has most recently been updated on June 23rd, 2022. The clinical trial originally posted on June 15th of the same year and is currently recruiting for 24 subjects at 1 location."
What are the aims of this clinical trial?
"The primary outcome of this trial, which will be assessed over a within-session peak change from pre-drug baseline to 15-120 min post-drug 1 and 15-240 min post-drug 2 administration; measured in each of the 6 laboratory sessions over about 3 weeks time frame is Negative affect. Secondary outcomes include Cognitive flexibility performance task (i.e. Wisconsin Card Sorting Task percentage of trials correct), Cognitive inhibition performance task (i.e Addiction Stroop Task reaction time to drug vs. neutral words presented in different colors), and Preference for natural reinforcement choice procedure (i.e Number of choices for money vs. avoiding"
Would this research be open to participants that are over 30 years old?
"This trial's minimum age limit is 18 and the maximum age an enrolled patient can be is 60."
Are there any restrictions for people who want to enroll in this research project?
"In order to participate in this research, individuals must have a history of benzodiazepine use and be between 18-60 years old. Up to 24 patients will be accepted into the clinical trial."
Is Alprazolam's usage in medicine unique compared to other drugs?
"Currently, there are 64 ongoing studies studying the combination of Alprazolam and morphine. Of these, 18 are in Phase 3. Most of the trials for Alprazolam then morphine are being conducted in Amersfoort, Noord Holland, but there are 292 locations running studies for Alprazolam then morphine."
How many people have signed up to be a part of this experiment?
"The most recent information on clinicaltrials.gov affirms that this study is looking for 24 participants at a single site. The trial was first announced on 6/15/2022 and updated on 6/23/2022."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
How responsive is this trial?
Most responsive sites:
- Tolan Park Medical Building: < 48 hours
Typically responds via
Average response time
- < 2 Days
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