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Propranolol Hydrochloride for Post-Traumatic Stress Disorder

Phase 2
Waitlist Available
Led By Alain Brunet, PhD.
Research Sponsored by Douglas Mental Health University Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the weighted average of the questionnaire responses will be calculated over a 12 month period
Awards & highlights

Study Summary

This trial will explore whether reactivating a trauma memory while under the influence of propranolol will help relieve symptoms of trauma-related disorders more effectively than current treatments.

Eligible Conditions
  • Post Traumatic Stress Disorder
  • Trauma and Stressor Related Disorders
  • Acute Stress Disorder
  • Adjustment Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the weighted average of the questionnaire responses will be calculated over a 12 month period
This trial's timeline: 3 weeks for screening, Varies for treatment, and the weighted average of the questionnaire responses will be calculated over a 12 month period for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
EuroQol five dimensions questionnaire with five-level scale
Secondary outcome measures
Hopkins Symptom Checklist - 25 (HSCL - 25).
Operational Police Stress Questionnaire (PSQ-OP)
Post-traumatic Checklist for the Diagnostic and Statistical Manual for Mental Disorders - 5th edition (PCL-5)
Other outcome measures
Attention subtest of the Paced Auditory Serial Addition Test (PASAT)
Coding subtest of the Wechsler Adult Intelligence Scale-IV
Color-Word Interference Test of the Delis-Kaplan Executive Function System
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Propranolol HydrochlorideExperimental Treatment1 Intervention
1mg / kg of propranolol hydrochloride administered as a capsule 60 minutes prior to memory reactivation
Group II: PlaceboPlacebo Group1 Intervention
Placebo manufactured as a capsule to mimic 1mg/kg of propranolol hydrochloride administered 60 minutes prior to memory reactivation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propranolol
FDA approved

Find a Location

Who is running the clinical trial?

Douglas Mental Health University InstituteLead Sponsor
29 Previous Clinical Trials
2,662 Total Patients Enrolled
Institut de Recherche Robert-Sauvé en Santé et en Sécurité du TravailOTHER
3 Previous Clinical Trials
158 Total Patients Enrolled
Alain Brunet, PhD.Principal InvestigatorDouglas Mental Health University Institute

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this project recruiting participants older than 35 years of age?

"To be eligible for this investigation, participants must be of age and have not reached their 65th birthday."

Answered by AI

How many volunteers are engaged in this experiment?

"Affirmative. Clinicaltrials.gov's listing for this trial confirms that it is actively recruiting participants, with 64 individuals needed to be enrolled at a single medical centre since its posting on March 30th 2017 and last update on June 16th 2021."

Answered by AI

To what medical disorders does Propranolol Hydrochloride provide relief?

"Propranolol Hydrochloride is commonly administered to treat cardiovascular mortality. Additionally, this medication has been proven effective at managing angina pectoris, myocardial infarction, and obstructive hypertrophic cardiomyopathy."

Answered by AI

What is the criteria for being eligible to join this research endeavor?

"This medical trial is recruiting 64 individuals aged 18 to 65 who have been diagnosed with a trauma-and stressor-related disorder and meet the following criteria: their traumatic event must be work-related, they should score at least 4 on the Clinical Global Impressions-Severity Scale., participants taking antidepressants must abstain from that morning dose when receiving the study's intervention. Additionally, candidates should either currently or previously worked for Quebec City Police Department, 911 dispatch in Quebec City, other police departments in Quebec province or for Ministry of Public Security as correctional service officer. Furthermore, those enrolled ought to exhibit symptoms associated with Acute Stress Disorder"

Answered by AI

Can participants still join the experiment?

"The latest report from clinicaltrials.gov states that this experiment is actively recruiting participants, having first been posted on March 30th 2017 and last edited June 16th 2021."

Answered by AI

To what extent can Propranolol Hydrochloride be considered safe for human consumption?

"As this is a Phase 2 study, and thus no efficacy data exists for Propanol Hydrochloride, we assigned it a safety rating of 2."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Alain Brunet, Ph.D. 2017. "Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03152175.
All > Post Traumatic Stress Disorder
~8 spots leftby Apr 2025
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