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Propranolol + Pembrolizumab for Skin Cancer
Study Summary
This trial is testing propranolol hydrochloride in combination with pembrolizumab to see if it is a safe and effective treatment for patients with stage IIIC-IV melanoma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- Your blood tests must show a certain level of white blood cells, red blood cells, and platelets.Your liver function tests should be within a certain range, and a different range applies if you have cancer that has spread to your liver.Your creatinine levels in your blood should be within a certain range.I have not had any other cancer that needed treatment in the last 3 years.I do not have any serious illnesses or social situations that would stop me from following the study's requirements.I am currently pregnant or nursing.I have been newly diagnosed with advanced melanoma and have not started treatment.You have a disease that can be measured using specific medical guidelines.Your total bilirubin levels should be normal, unless you have Gilbert's syndrome.You have a long-term autoimmune disease.I am currently taking non-selective beta-blockers for my condition.I have brain metastases and received radiation less than 4 weeks ago.I have had immunotherapy for cancer, but not for melanoma, and haven't received interferons or CTLA-4 inhibitors.I have not received a live vaccine in the last 30 days or during the trial.I am currently taking or have taken corticosteroids.I haven't taken steroids or immunosuppressants in the last 14 days.I cannot take beta-blockers due to health reasons.I can swallow and keep down pills.I do not have any other spreading cancers besides non-melanoma.I can provide a previous biopsy sample or am willing to have a new biopsy.I am fully active or can carry out light work.
- Group 1: Treatment (propranolol hydrochloride, pembrolizumab)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could you provide a synopsis of previous clinical research on Pembrolizumab?
"Pembrolizumab was first studied at Vanderbilt University in 1996 and has since been the subject of 918 clinical trials. At present, 1000 active studies are taking place with multiple locations across Buffalo, New york."
Can you tell me how many participants are partaking in this research project?
"Affirmative. Clinicaltrials.gov reveals that this clinical experiment, which was initially posted on 31st January 2018 is actively seeking recruitment of 47 people from 4 sites. It has been most recently updated on 8th September 2022."
What is the breadth of locations where this experimentation is taking place?
"Four major medical centres are active participants in this trial including Roswell Park Cancer Institute located in Buffalo, Cleveland Clinic Cancer Center situated near Cleveland, and Penn State Milton S. Hershy Medical Center's own cancer institute nearby Hershey."
Are there still opportunities for participants in this experiment?
"Data on clinicaltrials.gov ascertains that this investigation is actively seeking to enrol participants; the trial was first published January 31st 2018 and last modified September 8th 2022."
What health conditions does Pembrolizumab typically treat?
"Pembrolizumab is a viable medical intervention to treat malignant neoplasms, microsatellite instability high, and those with unresectable melanoma."
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