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Reconsolidation Blockade with Propranolol for PTSD

Phase 2
Waitlist Available
Led By Alain Brunet, Ph.D.
Research Sponsored by Douglas Mental Health University Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male or female 18-65 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up questionnaire administered at weeks 0, 1, 2, 3, 4 , 5, 6, 7, 13 and 26
Awards & highlights

Study Summary

This trial will examine whether a new method of reconsolidation blockade, which involves varying the contexts in which the weekly trauma memory retrieval will occur, is effective in treating PTSD among military personnel and Federal police officers.

Who is the study for?
This trial is for military personnel, Federal police officers, or veterans aged 18-65 with occupationally related PTSD as per DSM-5 criteria. Participants must be able to consent and females should use contraception. Exclusions include medical conditions that conflict with propranolol use, certain medication interactions, pregnancy, substance dependence, ongoing litigation related to trauma, strong dissociative tendencies, language barriers (non-English/French speakers), low blood pressure/heart rate, active suicidal thoughts or recent traumatic brain injury.Check my eligibility
What is being tested?
The study tests a modified reconsolidation therapy for psychological trauma using propranolol versus placebo. Over six weeks of treatment involving weekly sessions preceded by drug intake an hour before memory reactivation; the mismatch method varies contexts of retrieval. The hypothesis suggests this could improve PTSD symptoms more effectively than standard methods.See study design
What are the potential side effects?
Propranolol may cause side effects like dizziness due to lowered blood pressure, fatigue, trouble sleeping and cold hands or feet. It can also affect heart rhythm and breathing in some individuals.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 65 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~questionnaire administered at weeks 0, 1, 2, 3, 4 , 5, 6, 7, 13 and 26
This trial's timeline: 3 weeks for screening, Varies for treatment, and questionnaire administered at weeks 0, 1, 2, 3, 4 , 5, 6, 7, 13 and 26 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Beck Depression Inventory (BDI) scores
Clinical Global Impression-Improvement (CGI-I) scores
Dissociative Experiences Scale (DES-T)
+5 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Propranolol and standard trauma memory reactivation groupExperimental Treatment1 Intervention
Oral propranolol will be administered 60 minutes prior to writing (Treatment 1) or reading aloud a trauma narrative.
Group II: Propranolol and mismatch trauma memory reactivation groupActive Control1 Intervention
Oral propranolol will be administered 60 minutes prior to a memory reactivation procedure involving variations in the contexts where the trauma memory reactivations occur.
Group III: Placebo and mismatch trauma memory reactivation groupPlacebo Group1 Intervention
Oral placebo will be administered 60 minutes prior to a memory reactivation procedure involving variations in the contexts where the trauma memory reactivations occur.
Group IV: Placebo and standard trauma memory reactivation groupPlacebo Group1 Intervention
Oral placebo will be administered 60 minutes prior to writing (Treatment 1) or reading aloud a trauma narrative.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propranolol
FDA approved

Find a Location

Who is running the clinical trial?

Douglas Mental Health University InstituteLead Sponsor
29 Previous Clinical Trials
2,576 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,333 Previous Clinical Trials
25,747,208 Total Patients Enrolled
Alain Brunet, Ph.D.Principal InvestigatorDouglas Mental Health University Institute
2 Previous Clinical Trials
126 Total Patients Enrolled

Media Library

Placebo Clinical Trial Eligibility Overview. Trial Name: NCT04982211 — Phase 2
Post-Traumatic Stress Disorder Research Study Groups: Placebo and mismatch trauma memory reactivation group, Propranolol and standard trauma memory reactivation group, Placebo and standard trauma memory reactivation group, Propranolol and mismatch trauma memory reactivation group
Post-Traumatic Stress Disorder Clinical Trial 2023: Placebo Highlights & Side Effects. Trial Name: NCT04982211 — Phase 2
Placebo 2023 Treatment Timeline for Medical Study. Trial Name: NCT04982211 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Propranolol received regulatory approval from the FDA?

"Because there is only data supporting Propranolol's safety and none of its efficacy, it received a score of 2."

Answered by AI

For this particular test, are the patients' ages restricted in any way?

"This particular clinical trial is designed for patients aged 18-65. However, there are 433 other studies for minors and 1534 research trials available for senior citizens."

Answered by AI

Are we currently looking for people to participate in this research?

"This research is not looking for new participants at the moment. It was initially posted on August 1st 2021 and updated most recently on July 23rd. If you're interested in other studies, 2044 trials are currently enrolling patients with adjustment disorders and 43 studies are recruiting patients that want to take Propranolol."

Answered by AI

Does this research opportunity have any restrictions in terms of who can participate?

"Up to 150 individuals that have been diagnosed with adjustment disorders will be accepted into this clinical trial. Those interested should note that they must meet the following requirements: (i) Be between 18 and 65 years old;, (ii) Employed full-time as part of the Canadian or US military forces or the RCMP;, (iii) Veterans of the Canadian or US military forces or the RCMP;, (iv) On leave of absence from Canadian or US military forces, or the RCMP;, (v) Females of childbearing potential willing to use contraception for the duration of the treatment period of the study., (vi)"

Answered by AI

What conditions does Propranolol usually help alleviate?

"Propranolol is frequently used to lower the risk of cardiovascular mortality. Additionally, this medication can also provide relief for other conditions such as angina pectoris, myocardial infarction, and obstructive hypertrophic cardiomyopathy."

Answered by AI

How many people are allowed to participate in this clinical trial at any given time?

"Unfortunately, this study is not presently enrolling patients. The clinical trial was initially posted on 8/1/2021 and saw its last edit on 7/23/2021. However, there are 2044 other trials actively admitting participants with adjustment disorders and 43 studies for Propranolol that are currently looking for participants."

Answered by AI
~42 spots leftby Mar 2025