← Back to Search

Beta Blocker

Propranolol for PTSD

Phase 2

Waitlist Available

Led By Alain Brunet, Ph.D.

Research Sponsored by Douglas Mental Health University Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

For participants aged 40 years: accept to undergo an electrocardiogram assessment. The results of the electrocardiogram must be normal

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 to 26 weeks

Awards & highlights

Study Summary

This trial tests whether propranolol can help to treat symptoms of PTSD by reducing physiological reactions to trauma reminders.

Who is the study for?

This trial is for adults who have been living with chronic PTSD for at least six months and score high on a trauma impact scale. Participants over 40 must have a normal heart reading from an ECG. They should not start new medications during the study or be taking drugs that affect heart rhythm, and cannot be breastfeeding, have bipolar disorder or psychosis, substance abuse issues, high dissociation levels, or certain medical conditions.Check my eligibility

What is being tested?

The study tests if propranolol (a beta-blocker), given in short-acting and long-acting forms along with memory reactivation sessions, can reduce physical responses to trauma memories and ease PTSD symptoms compared to just propranolol without memory reactivation.See study design

What are the potential side effects?

Propranolol may cause low blood pressure, slow heartbeat, fatigue, dizziness upon standing up too fast due to lowered blood pressure (orthostatic hypotension), sleep disturbances, and could potentially worsen symptoms of asthma.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 40 or older and agree to a heart test that must show normal results.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ two weeks post-treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~two weeks post-treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and two weeks post-treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Electromyogram

Heart rate

Skin conductance

Secondary outcome measures

Memory Experience

PTSD symptom levels

Psychophysiological assessments

+1 more

Trial Design

5Treatment groups

Experimental Treatment

Group I: Propranolol + No Memory ReactivationExperimental Treatment1 Intervention

This arm involves administration of propranolol without recalling the traumatic event

Group II: Propranolol + Memory ReactivationExperimental Treatment1 Intervention

This arm involves recalling the traumatic event after administration of propranolol

Group III: Placebo + No Memory ReactivationExperimental Treatment1 Intervention

This arm involves administration of a placebo without recalling the traumatic event

Group IV: Placebo + Memory reactivationExperimental Treatment1 Intervention

This arm involves recalling the traumatic event after administration of a placebo

Group V: Open-label Propranolol + Memory ReactivationExperimental Treatment1 Intervention

All participants terminating the double-blind phase of the study will receive open-label reconsolidation blockade treatment with propranolol combined with recall of the traumatic event for six weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Propranolol

FDA approved

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Douglas Mental Health University InstituteLead Sponsor

29 Previous Clinical Trials

2,650 Total Patients Enrolled

Canadian Institutes of Health Research (CIHR)OTHER_GOV

1,341 Previous Clinical Trials

26,452,637 Total Patients Enrolled

Alain Brunet, Ph.D.Principal InvestigatorDouglas Institute Research Centre

2 Previous Clinical Trials

200 Total Patients Enrolled

Media Library

Propranolol (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT01349439 — Phase 2

Post-Traumatic Stress Disorder Research Study Groups: Propranolol + Memory Reactivation, Placebo + Memory reactivation, Placebo + No Memory Reactivation, Propranolol + No Memory Reactivation, Open-label Propranolol + Memory Reactivation

Post-Traumatic Stress Disorder Clinical Trial 2023: Propranolol Highlights & Side Effects. Trial Name: NCT01349439 — Phase 2

Propranolol (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01349439 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Propranolol been authorized by the FDA?

"Despite the lack of evidence that Propranolol is effective, there have been enough studies to warrant a safety rating of 2."

Answered by AI

Are octogenarians eligible for inclusion in this experiment?

"This clinical trial's eligibility stipulates that participants should not be older than 65 and must have attained the age of consent."

Answered by AI

Is it permissible for me to join this clinical research endeavor?

"The parameters for this clinical trial necessitate that potential participants manifest moral injury and be between 18 years old and 65. At the moment, 76 individuals are being accepted into the study."

Answered by AI

What therapeutic conditions is Propranolol commonly prescribed for?

"Propranolol is most commonly prescribed to reduce the mortality rate associated with cardiovascular illnesses. It also helps patients manage angina pectoris, myocardial infarction and obstructive hypertrophic cardiomyopathy."

Answered by AI

How many participants are currently being admitted to this medical experiment?

"At present, this medical trial is not seeking additional participants. The study was initially made public on March 1st 2011 and last modified June 23rd 2014. If you are searching for other clinical trials, there are 410 moral injury studies actively recruiting patients as well as 41 studies that include Propranolol in their methodology."

Answered by AI

What goals are investigators attempting to accomplish via this clinical experiment?

"This clinical trial will measure skin conductance over the two weeks post-treatment period as its primary outcome. Memory Experience, PTSD symptom levels and Quality of Life assessments will be administered at staggered time intervals ranging from 2 to 26 weeks after randomization as secondary outcomes."

Answered by AI

Is this clinical experiment actively accepting new volunteers?

"According to clinicaltrials.gov, this study is not actively recruiting patients; the initial post date was March 1st 2011 and it has been updated most recently on June 23rd 2014. However, there are currently 451 other trials in progress that still require participants."

Answered by AI