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Procedure

tDCS for Bipolar Disorder

N/A
Recruiting
Led By Jair C Soares, MD,PhD
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
diagnosis of Bipolar Disorder and clinically significant anhedonia
Diagnosis of Bipolar Disorder and clinically significant anhedonia
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 weeks
Awards & highlights

Study Summary

This trial is testing whether electrical stimulation can help people with anhedonia, by affecting the brain circuitry related to rewards.

Who is the study for?
This trial is for individuals with Bipolar Disorder who experience significant anhedonia (loss of pleasure) and mild depression symptoms. It's not suitable for those with recent substance abuse, personality disorders that affect participation, previous neurological conditions, severe medical issues, metal in the head, or if they're acutely suicidal or severely agitated.Check my eligibility
What is being tested?
The study tests transcranial direct-current stimulation (tDCS), a non-invasive brain stimulation technique. Participants will receive either active tDCS or a sham (placebo) treatment to see if it affects brain circuits related to reward and improves feelings of pleasure.See study design
What are the potential side effects?
tDCS may cause minor side effects like itching, tingling, or discomfort at the electrode site on the scalp. Some people might feel fatigue or headache after treatment. Serious side effects are rare when protocols are followed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with Bipolar Disorder and experience a significant loss of pleasure in most activities.
Select...
I have been diagnosed with Bipolar Disorder and experience a significant loss of pleasure in most activities.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
change in the fractional anisotropy of the uncinate fasciculus
Secondary outcome measures
change in symptoms of anticipatory anhedonia as assessed by the Temporal Experience of Pleasure Scale (TEPS)
change in symptoms of consummatory anhedonia as assessed by the Temporal Experience of Pleasure Scale (TEPS)
changes in symptoms of anhedonia as assessed by the Snaith-Hamilton Pleasure Scale modified for clinical administration (SHAPS-C)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: active tDCSExperimental Treatment1 Intervention
Group II: sham tDCSPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
active tDCS
2018
N/A
~790

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
904 Previous Clinical Trials
320,952 Total Patients Enrolled
2 Trials studying Anhedonia
148 Patients Enrolled for Anhedonia
Milken InstituteOTHER
7 Previous Clinical Trials
242 Total Patients Enrolled
Jair C Soares, MD,PhDPrincipal InvestigatorThe University of Texas Health Science Center, Houston

Media Library

tDCS (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05240352 — N/A
Anhedonia Research Study Groups: active tDCS, sham tDCS
Anhedonia Clinical Trial 2023: tDCS Highlights & Side Effects. Trial Name: NCT05240352 — N/A
tDCS (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05240352 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged less than fifty-five accepted for this research experiment?

"In accordance with the requirements of this inquiry, only individuals aged 18-50 are eligible for enrollment."

Answered by AI

Are there still opportunities for enrollment in this research program?

"The information currently accessible on clinicaltrials.gov states that this medical trial is no longer open for enrollment, having been posted on the 17th of October 2022 and edited most recently on the 12th of October 2022. Despite its closure to further participants, there are still 1,253 other trials looking for volunteers at present time."

Answered by AI

May I participate in this medical experiment?

"This clinical trial requires up to 45 participants aged 18-50 who have been diagnosed with Bipolar disorder and display clinically significant anhedonia as well as mild indicators of depression."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
Jair Soares 2022. "Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05240352.
All > Depression Houston
~18 spots leftby Apr 2025
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