Anti-inflammatory agent
Ibudilast for Alcohol Use Disorder
This trial is testing whether the anti-inflammatory drug ibudilast can help people with alcohol dependence reduce or stop drinking. The trial will last 6 weeks, and participants will be randomly assigned to receive either ibudilast or a placebo. Ibudilast is not approved by the FDA for use in the United States, but it has been used safely and effectively for many years in Asia.
Alcohol Effects on Drinking Behavior
This trial looks at how different people react to alcohol and other substances, and whether this predicts how much they will drink in the future. It also looks at how people's responses to alcohol change if their drinking habits do.
Procedure
TMS for Alcohol Use Disorder
"This trial aims to test if using a single session of brain stimulation guided by MRI can help reduce the brain's response to alcohol cues in people with Alcohol Use Disorders, potentially lowering the risk of relapse
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Trials for Substance Abuse Patients
Behavioral Intervention
CRP + S&A for Substance Use Disorders
This trial is testing three different treatments to help improve outcomes for people with substance abuse problems. Veterans at the Charleston VA Psychiatric inpatient unit who are admitted may be invited to participate.
Behavioural Intervention
Psycho-education & Understanding Bipolar Medications Therapy + MBSR + ISRT + Bipolar-Specific CBT for Bipolar Disorder
This trial will study how to better treat bipolar patients who are suicidal by looking at environmental and psychological factors, as well as implementing a 6-week intervention program.
Behavioural Intervention
Parent-Child Assistance Program for Substance Use During Pregnancy
This trial helps 200 mothers in Oklahoma who use alcohol/drugs during pregnancy & their children by providing support/resources for 3 years. Benefits include substance use disorder treatment, birth control, abstinence, child custody, & criminal justice involvement.
Trials for Binge Drinking Patients
Neuroeconomic Decision-Making for Alcoholism
This trial uses techniques from neuroeconomics, which is a mix of psychology, neuroscience, and economics, to study how the brain makes decisions about alcohol consumption. They will be using functional magnetic resonance imaging (fMRI) to look at brain activity while participants make hypothetical decisions about alcohol consumption at various prices. There will be an in-scanner alcohol cue exposure task where participants will view images of alcoholic or neutral beverages before making their decisions.
Trials With No Placebo
Behavioural Intervention
Jaspr Health App for Suicidal Thoughts
This trial is testing a new expanded Jaspr2.0 to efficiently and reliably aid delivery of recommended best-practices for the treatment of suicidal ideation in adults, including suicidal individuals who also misuse alcohol.
Behavioral Intervention
CRP + S&A for Substance Use Disorders
This trial is testing three different treatments to help improve outcomes for people with substance abuse problems. Veterans at the Charleston VA Psychiatric inpatient unit who are admitted may be invited to participate.
Behavioural Intervention
Psycho-education & Understanding Bipolar Medications Therapy + MBSR + ISRT + Bipolar-Specific CBT for Bipolar Disorder
This trial will study how to better treat bipolar patients who are suicidal by looking at environmental and psychological factors, as well as implementing a 6-week intervention program.
Trials Offering Remuneration
Behavioural Intervention
Alcohol Impact on Decision-Making During HIV Risk Situations
This trial is studying how alcohol impacts decisions about engaging in risky sex. Healthy adults ages 21-65 without alcohol use disorder are eligible. Participants will have 2 study visits, 1 month apart. They will consume alcohol at 1 visit, chosen at random.
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Frequently Asked Questions
Introduction to alcoholism
What are the top hospitals conducting alcoholism research?
When it comes to the battle against alcoholism, top hospitals are stepping up to the plate with innovative clinical trials aimed at finding effective treatments. In Charleston, South carolina, the Medical University of South Carolina leads the way with four active trials and a total of 25 trials conducted throughout their history. Since their first recorded alcoholism trial in 2009, this institution has been committed to exploring new avenues for helping those struggling with addiction. Meanwhile, in Philadelphia's University of Pennsylvania Center for Studies of Addiction, researchers are currently engaged in three ongoing alcoholism trials as they kickstart their journey into understanding this complex condition. Despite having only completed four studies since recording their initial trial in 2021, this center is making waves in the field.
At the University of Colorado Anschutz Medical Campus located in Aurora, three active alcoholism trials are taking place. Though relatively new to studying alcoholism compared to other institutions on this list (with their first recorded trial dating back only to 2020), they have already demonstrated a dedication towards advancing our knowledge and treatment options for individuals affected by alcohol addiction.
Notably contributing as well is Yale University situated in New Haven where two current clinical tests focus on combating alcoholism. With five previous investigations under its belt since initiating research efforts backin2016,Yale continues pushing forward toward breakthroughs that can transform lives.
Rounding out these leading medical centers is another establishment from Philadelphia—the University of Pennsylvania—where two active clinical trials concentrate on tackling alcoholism head-on.They have completed thirteen all-time studies thus far after embarking upon pioneering endeavors concerning such cases since1998
These hospitals' commitment and tireless efforts underline how crucial it is to find solutions for those grappling with addiction while fostering a sense of hope that through continued research we will uncover novel interventions and approaches leading us towards a society where recovery from Alcohol Use Disorder becomes more attainable than ever before
Which are the best cities for alcoholism clinical trials?
Providence, Rhode island, emerges as one of the top cities for alcoholism clinical trials with 9 ongoing studies focusing on Alcohol Use Disorder Only, Motivational + Family Check-up (MET+FCU), and Lamotrigine among others. Baltimore, Maryland follows closely behind with 7 active trials exploring interventions like Mifepristone, Pregabalin plus BBCET, and Intranasal Oxytocin. New Haven, Connecticut showcases its commitment to research with 6 ongoing trials investigating treatments such as patients receiving 300mg PREG, Active Treatment, and Guanfacine ER. Lastly, Philadelphia in Pennsylvania and New york City both contribute to advancing alcoholism treatment through their respective active trials including XR-NTX 380 mg intramuscular injection and Adaptive Tailored (TA) approaches. These cities offer individuals struggling with alcoholism opportunities to participate in innovative clinical trials that may improve outcomes for this challenging condition.
Which are the top treatments for alcoholism being explored in clinical trials?
Exciting advancements are taking place in the realm of alcoholism treatment, with clinical trials investigating several promising approaches. One notable contender is oxytocin, currently being explored in two active trials and a total of nine all-time alcoholism trials since its introduction in 2014. Another intriguing avenue under investigation is the use of alcohol itself as a potential treatment, with two ongoing trials and twelve all-time trials dedicated to exploring this unconventional approach since 2008. These innovative studies hold great promise for improving outcomes and providing new avenues for individuals struggling with alcoholism.
What are the most recent clinical trials for alcoholism?
Recent clinical trials have brought new hope for individuals struggling with alcoholism. One promising study investigated the effectiveness of Semaglutide, administered in 3 milligram and 7 milligram doses, as a potential treatment option. Another trial focused on Acetyl-l-carnitine and its impact on alcohol dependency. Additionally, Semaglutide was also studied independently to assess its effectiveness in combating alcoholism. Full-spectrum Cannabidiol has shown promise in Phase 2 and Phase 3 trials for treating alcohol use disorder. Lastly, Ibudilast is being evaluated in Phase 2 trials as a possible therapeutic intervention for those battling alcoholism. These exciting developments offer renewed optimism for improving outcomes and quality of life among individuals affected by this challenging condition.
What alcoholism clinical trials were recently completed?
Several recent clinical trials addressing alcoholism have achieved significant milestones, highlighting the ongoing efforts to combat this challenging condition. In December 2021, a trial sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) concluded its investigation into ASP8062. Similarly, in September 2021, Dicerna Pharmaceuticals completed their trial evaluating the potential of DCR-AUD as a treatment option. Additionally, Denver Health and Hospital Authority accomplished an Enhanced linkage study in January 2021. These advancements in research signify crucial steps towards understanding and developing effective interventions for individuals struggling with alcohol addiction.