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Cognitive Training + Brain Stimulation for Alcoholism

N/A
Recruiting
Led By Jazmin Camchong, PhD
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 4 months post-intervention
Awards & highlights

Study Summary

This trial is testing whether a combination of electrical brain stimulation and cognitive training can help people with alcohol addiction maintain abstinence. They will also look at whether genetic or epigenetic differences are associated with variation in how well people respond to the treatment.

Who is the study for?
This trial is for individuals with Alcohol Use Disorder (AUD) who are committed to staying in a treatment program and have been abstinent from alcohol. They must meet specific mental health criteria, not have other primary substance use disorders except caffeine or nicotine, and cannot have certain neurological conditions or contraindications for tDCS or MRI.Check my eligibility
What is being tested?
The TANGO study tests if combining brain stimulation (tDCS) targeting the DLPFC region with cognitive training can improve executive function and help maintain abstinence in AUD patients. It also explores how genetic profiles might influence treatment response.See study design
What are the potential side effects?
Potential side effects of tDCS may include discomfort at the electrode site, itching, tingling, headache, fatigue, nausea. Cognitive training is generally safe but could potentially cause temporary mental fatigue.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 4 months post-intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 4 months post-intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in D-KEFS Color Word score
Change in D-KEFS Trail Making (1-5) score
Change in D-KEFS Verbal Frequency score
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Participants receiving active transcranial direct current stimulation (tDCS)Experimental Treatment2 Interventions
Participants in this group will receive 5 sessions of active transcranial direct current stimulation (tDCS) to dorsolateral prefrontal cortex (DLPFC) while in the Lodging Plus treatment program and then 5 remote sessions of active tDCS to DLPFC after discharge from the treatment program. All participants will engage in executive functioning tasks for cognitive training during tDCS intervention (active or sham) to prime the engagement of the nucleus accumbens prefrontal cortex circuit. All participants will complete 4 MRI sessions. Craving measures will be collected before the first and after the last day of tDCS sessions. Follow-up interviews will be conducted monthly during a 4-month follow-up period after intervention completion to query relapse status. The first two follow-up interviews, at approximately 1- and 2-months post-intervention, will also include collection of cognition data.
Group II: Participants receiving active and sham active transcranial direct current stimulation (tDCS)Placebo Group2 Interventions
Participants in this group will receive 5 sessions of sham-tDCS sessions while in the Lodging Plus treatment program and then 5 remote sessions of active-tDCS to DLPFC after discharge from the treatment program. All participants will engage in executive functioning tasks for cognitive training during tDCS intervention (active or sham) to prime the engagement of the nucleus accumbens prefrontal cortex circuit. All participants will complete 4 MRI sessions. Craving measures will be collected before the first and after the last day of tDCS sessions. Follow-up interviews will be conducted monthly during a 4-month follow-up period after intervention completion to query relapse status. The first two follow-up interviews, at approximately 1- and 2-months post-intervention, will also include collection of cognition data.

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,379 Previous Clinical Trials
1,588,452 Total Patients Enrolled
9 Trials studying Alcoholism
2,085 Patients Enrolled for Alcoholism
Jazmin Camchong, PhDPrincipal InvestigatorUniveristy of Minnesota Department of Psychiatry & Behavioral Sciences
3 Previous Clinical Trials
104 Total Patients Enrolled
1 Trials studying Alcoholism
86 Patients Enrolled for Alcoholism

Media Library

Executive Function Focused Cognitive Training Clinical Trial Eligibility Overview. Trial Name: NCT05062369 — N/A
Alcoholism Clinical Trial 2023: Executive Function Focused Cognitive Training Highlights & Side Effects. Trial Name: NCT05062369 — N/A
Executive Function Focused Cognitive Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT05062369 — N/A
Alcoholism Research Study Groups: Participants receiving active transcranial direct current stimulation (tDCS), Participants receiving active and sham active transcranial direct current stimulation (tDCS)

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How large is the sample size of this experiment?

"That is correct. Information available on clinicaltrials.gov indicates that this study is recruiting patients as we speak. The 40 participants will be drawn from a single location and the trial was originally posted on March 3rd, 2022."

Answered by AI

Are there still opportunities for people to sign up for this clinical trial?

"The trial is currently seeking patients and was last updated on 3/29/2022. This particular clinical trial is looking for 40 patients from 1 medical site."

Answered by AI

Who might be most likely to respond positively to this treatment?

"For this study, we are looking for 40 individuals aged 18-65 that suffer from addiction and meet the following requirements: The desire to stay in the Lodging Plus program until the study's intervention is completed and no recent alcohol use."

Answered by AI

Does this research involve testing on elderly individuals?

"The age requirements for this trial are that patients must be over 18 years old but below 65 years old."

Answered by AI

Who else is applying?

What site did they apply to?
University of Minnesota
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
2022. "Tdcs And cogNitive traininG cOmbined for AUD (TANGO)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05062369.
All > Alcoholism > Addiction
~16 spots leftby Sep 2025
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