Approach Avoidance Training for Alcohol Drinking

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
VA San Diego Healthcare System, San Diego, CA, San Diego, CA
Alcohol Drinking+2 More
Approach Avoidance Training - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

The proposed study will test a novel treatment for alcohol use disorders (AUD) to determine if it helps Veterans reduce their hazardous drinking and recover from alcohol-related functional impairments across social, occupational, and domestic domains. To do so, the investigators will evaluate clinical, cognitive, and neural effects of a computer-delivered Approach Avoidance Training (AAT) treatment - which changes implicit tendencies to approach alcohol-related cues - in conjunction with standard VA care. The project will support RR&D's mission to improve Veterans' participation in their lives and community by determining if this innovative alternative technique can improve recovery outcomes for Veterans with AUD and exploring how the intervention works.

Eligible Conditions

  • Alcohol Drinking
  • Alcohol Use Disorder

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: Baseline, post (week 6), follow up 1 (3 mo.), followup 2 (6 mo.)

Baseline, post (week 6)
Change in Alcohol Approach Avoidance Behavioral Assessment (approach bias score)
Change in Alcohol Approach Avoidance Imaging Assessment (BOLD neural signal)
Change in Alcohol Cue Reactivity fMRI task
Change in Alcohol Go/no-go (GNG) fMRI task (BOLD neural signal)
Week 6
Change in Sheehan Disability Scale (SDS)
Change in The Substance Use Recovery Evaluator (SURE)
Change in the Drinker Inventory of Consequences (DrInC)
Change in the Timeline Follow-back Procedure (TLFB)

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Approach Avoidance Training
1 of 2
Sham Training
1 of 2
Experimental Treatment
Non-Treatment Group

176 Total Participants · 2 Treatment Groups

Primary Treatment: Approach Avoidance Training · Has Placebo Group · N/A

Approach Avoidance Training
Behavioral
Experimental Group · 1 Intervention: Approach Avoidance Training · Intervention Types: Behavioral
Sham Training
Behavioral
ShamComparator Group · 1 Intervention: Sham Training · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Approach Avoidance Training
2015
N/A
~60

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, post (week 6), follow up 1 (3 mo.), followup 2 (6 mo.)
Closest Location: VA San Diego Healthcare System, San Diego, CA · San Diego, CA
Photo of san diego 1Photo of san diego 2Photo of san diego 3
2006First Recorded Clinical Trial
4 TrialsResearching Alcohol Drinking
45 CompletedClinical Trials

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,459 Previous Clinical Trials
2,748,737 Total Patients Enrolled
26 Trials studying Alcohol Drinking
3,864 Patients Enrolled for Alcohol Drinking
Jessica A Bomyea, PhDPrincipal InvestigatorVA San Diego Healthcare System, San Diego, CA
1 Previous Clinical Trials
100 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.