This trial is evaluating whether Topiramate will improve 1 primary outcome in patients with Alcoholism. Measurement will happen over the course of 12 weeks.
This trial requires 160 total participants across 2 different treatment groups
This trial involves 2 different treatments. Topiramate is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
"Alcohol is the most important risk factor for the progression from heavy alcohol consumption to alcoholism. However, the family history for this disorder does not seem to be an independent risk factor in these families." - Anonymous Online Contributor
"Alcohol can lead to headaches; trouble sleeping and restlessness; dizziness; blurred vision; sore tongue, dizziness and nausea; loss of balance and feeling tired; and confusion. Long-term heavy drinking can lead to the development of an alcohol-induced liver disease called [alcoholic liver failure (ALD)] (a type of cirrhosis). Alcohol-induced liver disease is rare but can be life-threatening." - Anonymous Online Contributor
"Alcohol drinking is primarily related to peer pressure, curiosity, and fun. Alcohol consumption is correlated with certain peer groups; alcohol drinkers tend to associate with other drinkers." - Anonymous Online Contributor
"Alcohol is the single most widely used drug in America among both men and women. About 12 billion alcoholic beverages are consumed each year in the United States, or around 8% of U.S. fluid consumption." - Anonymous Online Contributor
"We show a strong association between alcoholism and an increased risk for developing prostate cancer. Drinking > 10 drinks/day for > 5 years increased the risk by three-fold compared to a nondrinking men." - Anonymous Online Contributor
"Alcohol drinking is a highly widespread and common behavioural problem and is treated with the same general principles used for other addictive behaviours. Treatment should first aim to reduce the number of drinks, then to reduce the frequency (drinking on a daily basis), and finally to help those with drinking problems to develop and use skills for coping with their drinking. Attention should also be paid to managing co-occurring mental health difficulties, particularly depression." - Anonymous Online Contributor
"Alcohol drinking is a high risk behavior that can impact personal health. A number of research studies found that it is positively related to many types of mental disorders, such as depression, anxiety, and personality disorders. Furthermore; the negative consequences of alcohol drinking are very widespread as shown by the increase in incidence of alcoholic liver disease and many forms of cancers (cancer of the oral cavity, pancreatic cancer, non-Hodgkin's lymphoma, colorectal cancer, breast cancer, esophageal cancer, larynx cancer, and pharynx cancer, hepatic cancer, gastro-intestinal cancer, urinary bladder cancer, prostate cancer and many, many others)." - Anonymous Online Contributor
"The vast majority of patients receiving LTG had experienced a withdrawal from topiramate, the most common reasons being rebound effects (72%), headache (56%), gastrointestinal side effects (55%), and dizziness (33%). In contrast to this, only 20% of patients on LTG were discontinued due to side effects. Patients receiving topiramate in combination with other treatments were no more likely to withdraw from LTG or discontinue treatment due to side effects than patients receiving LTG alone." - Anonymous Online Contributor
"Topiramate may help people who are experiencing trouble concentrating in the classroom, when being interviewed for employment, or when driving or operating machinery where they have a high likelihood of making a dangerous error. For many students, topiramate may be useful for managing seizures. It may also be useful to prevent seizures for some people who are not having seizures, because this can decrease the chance that they will do something that puts them at risk for a seizure. It may also help people with alcohol or other drug problems. Topiramate may help people who have trouble controlling behavior of their body's natural emotions such as anger, jealousy, or sadness." - Anonymous Online Contributor
"In the present data, topirotin had a significant efficacy compared with the placebo. In a recent study, findings supports the recent proposal to use topirotin in the treatment of alcohol withdrawal." - Anonymous Online Contributor
"Alcohol-related diseases can also affect teenagers. So, health care professionals and those who are parenting teenagers are important for educating them on the risks of alcohol. There are many different types of [alcohol-related diseases|alcoholics]. Drinking alcohol in a safe and healthy way is an important thing. Drinking alcohol, and in particular binge drinking, can cause alcohol related health problems." - Anonymous Online Contributor
"The recent developments in the development of topiramate were discussed to include recent clinical trials of the drug, the advancement of mechanistic studies, new clinical trials for epilepsy, psychiatric disorders and neuroprotection, and recent trials in mood disorders. Current evidence supporting its use in sleep disorders is weak. Topiramate was evaluated in an open-label study of patients with cognitive dysfunctions associated with alcohol abuse, an area where additional research has been warranted. Overall, most trials have shown a modest efficacy for topiramate in cognitive impairment in alcohol abusers. Clinicians should consider an individualized treatment plan based on the patient’s symptoms, alcohol use history, and the patient’s preference." - Anonymous Online Contributor