Treatment Resistant Depression Clinical Trials 2023

Browse 100 Treatment Resistant Depression Medical Studies Across 142 Cities
1 Phase 3 Trial · 266 Treatment Resistant Depression Clinics

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Clinical Trials Treatment Resistant Depression Clinical Trials 2023

Reviewed by Michael Gill, B. Sc.

Image of UPMC East in Monroeville, United States.

Intervention: RxWellfor Mood Disorders

Monroeville, PA

This trial aims to improve peri-operative care, hasten recovery, and save resources for UPMC ISD by using a platform called RxWell.

UPMC East (+3 Sites)Murat Kaynar

Image of Northwestern University in Chicago, United States.

Self-guided Digital Intervention For NSSIfor Depression

This trial will test a digital mental health intervention for young adults who self-injure, to see if it is feasible and leads to better outcomes than a control group.

Waitlist Available

Northwestern UniversityDavid C Mohr, PhD

Image of Johns Hopkins School of Nursing in Baltimore, United States.

Open Label Pilotfor Depression

This trial will test an adapted protocol, CAPABLE Family, which builds upon the CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early stage dementia and their caregivers.

Waitlist Available

Johns Hopkins School of NursingSarah Szanton, PhD, RN

Image of University of Alberta in Edmonton, Canada.

Intensive Use Of Patient Reported Outcome Measures And Open PROM Availability To Treating Neurologistfor Multiple Sclerosis

Edmonton, Canada

This trial is examining whether more routine and frequent measurement of Patient Related Outcome Measures (PROMs) in the care of patients with MS improves patient depression and anxiety outcomes in addition to patient care satisfaction.

University of Alberta

Image of St. Luke's Health System in Boise, United States.

SPI+for Suicide

This trial will compare the effectiveness of two brief suicide prevention interventions in reducing suicidal ideation and behavior, and increasing uptake of outpatient mental healthcare services, over 12 months.

Waitlist Available

St. Luke's Health SystemAnna K Radin, DrPH, MPH

Image of First Choice Community Healthcare - South Broadway Medical Center in Albuquerque, United States.

Collaborative Care Plusfor Opioid Use Disorder

Albuquerque, NM

This trial will develop and test an intervention to reduce the risk of suicide and overdose among people with opioid use disorder and PTSD/depression.

Waitlist Available

First Choice Community Healthcare - South Broadway Medical Center (+17 Sites)Miriam Komaromy

Image of OMNI Medical Services in Boca Raton, United States.

Cannabis, Medicalfor Chronic Pain

This trial will test the effectiveness and safety of medical cannabis for various chronic medical conditions.

OMNI Medical Services (+15 Sites)Dr. Ryan O Lakin, MD JD

Image of Massachusetts General Hospital in Boston, United States.

QUITfor Smoking/Cigarette Smoking

This trial is testing a cognitive-behavioral-based intervention to help smokers living with HIV quit smoking by reducing anxiety and depression.

Massachusetts General Hospital (+2 Sites)Jasper Smits, PhD

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Dexmedetomidine Hydrochloride Groupfor Postoperative Cognitive Dysfunction

Toronto, Canada

This trial will investigate whether the drug Dexmedetomidine can prevent long-term cognitive impairment after cardiac surgery.

Waitlist Available

FDA Approved Drug

Sunnybrook Health Sciences CentreSinziana Avramescu, MD,PhD,FRCPC

Image of Johns Hopkins University in Baltimore, United States.

Behavioral Activation - Rehabilitationfor Depression

This trial looks at a new therapy to help people who have survived respiratory failure and are struggling with depression and physical problems.

Johns Hopkins UniversityAnn M Parker, MD

10 Treatment Resistant Depression Clinical Trials Near Me

Top Hospitals for Treatment Resistant Depression Clinical Trials

Image of University of New Mexico Family Health Clinic, North Valley in New Mexico.

University of New Mexico Family Health Clinic, North Valley

Albuquerque

2Active Trials

2All Time Trials for Treatment Resistant Depression

2021First Treatment Resistant Depression Trial

Image of University of New Mexico Family Health Clinic, Southeast Heights in New Mexico.

University of New Mexico Family Health Clinic, Southeast Heights

Albuquerque

2Active Trials

2All Time Trials for Treatment Resistant Depression

2021First Treatment Resistant Depression Trial

Image of Clinica Sierra Vista - Baker Street Village CHC in California.

Clinica Sierra Vista - Baker Street Village CHC

Bakersfield

2Active Trials

2All Time Trials for Treatment Resistant Depression

2021First Treatment Resistant Depression Trial

Image of Clinica Sierra Vista - Kern River Health Center in California.

Clinica Sierra Vista - Kern River Health Center

Wofford Heights

2Active Trials

2All Time Trials for Treatment Resistant Depression

2021First Treatment Resistant Depression Trial

Image of Hubert Humphrey Comprehensive Health Center in California.

Hubert Humphrey Comprehensive Health Center

Los Angeles

2Active Trials

2All Time Trials for Treatment Resistant Depression

2021First Treatment Resistant Depression Trial

Top Cities for Treatment Resistant Depression Clinical Trials

Image of Albuquerque in New Mexico.

Albuquerque

10Active Trials

University of New Mexico Family Health Clinic, North ValleyTop Active Site

Image of San Diego in California.

San Diego

8Active Trials

VA San Diego Healthcare System, San Diego, CATop Active Site

Treatment Resistant Depression Clinical Trials by Phase of Trial

N/A Treatment Resistant Depression Clinical Trials

85Active Treatment Resistant Depression Clinical Trials

85Number of Unique Treatments

127Number of Active Locations

Treatment Resistant Depression Clinical Trials by Age Group

< 18 Treatment Resistant Depression Clinical Trials

7Active Treatment Resistant Depression Clinical Trials

Behavioral Activation Therapy Kind Minds Program Suubi-Mhealth Computerized cognitive training (CCT) using EndeavorRx Family Cognitive Behavioral Prevention EFFT intervention Attachment and Biobehavioral Catch-up

Most Recent Treatment Resistant Depression Clinical Trials

Clinical Trial

Began Recruiting Date

Phase

Behavioral Intervention Group (MOTIVATE) for Musculoskeletal Pain

8/21/2023

N/A

Intervention group for Depression

8/1/2023

N/A

Light to Moderate Physical Activity for Quality of Life

8/1/2023

N/A

Arm 1: 12 month MS CATCH tool intervention for Multiple Sclerosis

8/1/2023

N/A

CCAPB (intervention) for Premature Birth

7/17/2023

N/A

Top Treatments for Treatment Resistant Depression Clinical Trials

Treatment Name

Active Treatment Resistant Depression Clinical Trials

All Time Trials for Treatment Resistant Depression

First Recorded Treatment Resistant Depression Trial

Endotoxin

2

4

2014

Intervention: RxWell

1

1

2023

Self-guided digital intervention for NSSI

1

1

2024

Open Label Pilot

1

1

2022

Intensive Use of Patient Reported Outcome Measures and Open PROM Availability to Treating Neurologist

1

1

2021

Recently Completed Studies with FDA Approved Treatments for Treatment Resistant Depression

Treatment

Year

Sponsor

ALTO-100 PO Tablet

2022

Alto Neuroscience

Ketamine

2022

Washington University School of Medicine

Intravenous Ketamine

2022

Rebecca Price

PCN-101

2022

Perception Neuroscience

ALTO-100 PO tablet

2021

Alto Neuroscience

ALTO-300 PO tablet

2021

Alto Neuroscience

NBI-1065846

2021

Neurocrine Biosciences

Drug: CVL-354

2021

Cerevel Therapeutics, LLC

60 mg PRAX-114

2021

Praxis Precision Medicines

REL-1017

2021

Relmada Therapeutics, Inc.

About The Author

Michael Gill - B. Sc.

First Published: October 22nd, 2021

Last Reviewed: August 27th, 2023

References¹ Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x. https://pubmed.ncbi.nlm.nih.gov/11556941² Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. https://pubmed.ncbi.nlm.nih.gov/11556941³ Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. doi: 10.1001/archinte.166.10.1092. https://pubmed.ncbi.nlm.nih.gov/16717171⁴ Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. https://pubmed.ncbi.nlm.nih.gov/16717171⁵ Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4. https://pubmed.ncbi.nlm.nih.gov/2748771⁶ Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. https://pubmed.ncbi.nlm.nih.gov/2748771⁷ Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. https://pubmed.ncbi.nlm.nih.gov/6880820⁸ Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83. https://pubmed.ncbi.nlm.nih.gov/1593914⁹ EuroQol Group. EuroQol--a new facility for the measurement of health-related quality of life. Health Policy. 1990 Dec;16(3):199-208. https://pubmed.ncbi.nlm.nih.gov/10109801¹⁰ Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001 Jul;2(4):297-307. doi: 10.1016/s1389-9457(00)00065-4. https://pubmed.ncbi.nlm.nih.gov/11438246

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