Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder

Western Psychiatric Institute and Clinic, Pittsburgh, PA
Targeting 2 different conditionsTranscranial Magnetic Stimulation +3 moreN/ARecruitingLed by Rebecca B Price, PhDResearch Sponsored by Rebecca Price

Study Summary

This trial will help to identify which part of the brain is linked with compulsive behaviors, in order to develop better treatments for those with compulsions.

Eligible Conditions
  • Obsessive-Compulsive Disorder
  • Compulsive Behavior

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have reported compulsive behaviors that are concerning to you and have been evaluated by a healthcare professional.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90min-1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90min-1 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Brain activation in target region
Duration of compulsive behaviors in response to laboratory triggers
Effort to resist compulsive behaviors in response to laboratory triggers
+5 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: cTBS + Habit Override TrainingExperimental Treatment2 Interventions
Transcranial Magnetic Stimulation delivered in a continuous Theta Burst Stimulation (cTBS) pattern, paired with Habit Override Training.
Group II: Sham TBS + Habit Override TrainingActive Control2 Interventions
Sham Transcranial Magnetic Stimulation, paired with Habit Override Training.
Group III: cTBS + Sham TrainingActive Control2 Interventions
Transcranial Magnetic Stimulation delivered in a continuous Theta Burst Stimulation (cTBS) pattern, paired with Sham Training.
Group IV: Sham TBS + Sham TrainingPlacebo Group2 Interventions
Sham Transcranial Magnetic Stimulation, paired with Sham Training.
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Magnetic Stimulation
Completed Phase 4
Habit Override Practice

Find a site

Who is running the clinical trial?

Rebecca PriceLead Sponsor
6 Previous Clinical Trials
468 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,668 Previous Clinical Trials
1,985,606 Total Patients Enrolled
64 Trials studying Obsessive-Compulsive Disorder
13,721 Patients Enrolled for Obsessive-Compulsive Disorder
Rebecca B Price, PhDPrincipal Investigator
University of Pittsburgh
1 Previous Clinical Trials
200 Total Patients Enrolled

Media Library

Habit Override Practice Clinical Trial Eligibility Overview. Trial Name: NCT04580043 — N/A
Obsessive-Compulsive Disorder Research Study Groups: Sham TBS + Habit Override Training, cTBS + Sham Training, Sham TBS + Sham Training, cTBS + Habit Override Training
Obsessive-Compulsive Disorder Clinical Trial 2023: Habit Override Practice Highlights & Side Effects. Trial Name: NCT04580043 — N/A
Habit Override Practice 2023 Treatment Timeline for Medical Study. Trial Name: NCT04580043 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an opportunity to partake in this research project?

"This research initiative is open to a cohort of 200 individuals aged 18-60 that demonstrate compulsive behaviors. To be eligible, they must also agree to video taping and confirm their residence in the Pittsburgh area for at least 5 weeks."

Answered by AI

How many volunteers are currently participating in this experiment?

"Confirmed. displays that the research was first announced on December 28th 2020, and is presently recruiting participants. 200 volunteers are needed from 1 site to take part in the study."

Answered by AI

Are recruitment efforts still ongoing for this research project?

"Indeed, states that this trial is currently accepting patients after being initially posted on December 28th 2020 and updated most recently on August 14th 2022. 200 participants are needed at a single medical site."

Answered by AI

Is this experiment recruiting senior citizens?

"This trial necessitates that any patient enrolling is between 18 and 60 years old. Meanwhile, there are other studies targeting minors as well as those over 65 years of age with 26 trials and 68 trials respectively."

Answered by AI

Who else is applying?

What state do they live in?
What site did they apply to?
Western Psychiatric Institute and Clinic
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
~90 spots leftby Jan 2026