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Habit Override Practice for Obsessive-Compulsive Disorder

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Obsessive-Compulsive Disorder+1 MoreHabit Override Practice - Behavioral
Eligibility
18 - 60
All Sexes
What conditions do you have?
Select

Study Summary

This trial will help to identify which part of the brain is linked with compulsive behaviors, in order to develop better treatments for those with compulsions.

Eligible Conditions
  • Obsessive-Compulsive Disorder
  • Compulsive Behavior

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

1
Target: frontal pole; Order: frontal pole first
1
TMS targeting anterior OFC networks
1
TMS+DCS

Study Objectives

0 Primary · 8 Secondary · Reporting Duration: 90min-1 week

1 week
Brain activation in target region
Duration of compulsive behaviors in response to laboratory triggers
Effort to resist compulsive behaviors in response to laboratory triggers
Intensity of urges to perform compulsive behaviors in response to laboratory triggers
Obsessive Compulsive Inventory-Revised (OCI-R)
WHO Disability Assessment Scale 2.0
Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
90min-1 week
Goal-directed cognition

Trial Safety

Safety Progress

1 of 3

Similar Trials

1
Target: frontal pole; Order: frontal pole first
1
TMS targeting anterior OFC networks
2
TMS+DCS

Trial Design

4 Treatment Groups

Sham TBS + Habit Override Training
1 of 4
cTBS + Sham Training
1 of 4
cTBS + Habit Override Training
1 of 4
Sham TBS + Sham Training
1 of 4

Active Control

Experimental Treatment

Non-Treatment Group

200 Total Participants · 4 Treatment Groups

Primary Treatment: Habit Override Practice · Has Placebo Group · N/A

cTBS + Habit Override TrainingExperimental Group · 2 Interventions: Habit Override Practice, Transcranial Magnetic Stimulation · Intervention Types: Behavioral, Device
Sham TBS + Sham TrainingShamComparator Group · 2 Interventions: Sham Transcranial Magnetic Stimulation, Sham Training · Intervention Types: Device, Behavioral
Sham TBS + Habit Override TrainingActiveComparator Group · 2 Interventions: Sham Transcranial Magnetic Stimulation, Habit Override Practice · Intervention Types: Device, Behavioral
cTBS + Sham TrainingActiveComparator Group · 2 Interventions: Sham Training, Transcranial Magnetic Stimulation · Intervention Types: Behavioral, Device
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Habit Override Practice
2017
N/A
~80
Transcranial Magnetic Stimulation
2011
Completed Phase 4
~580

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 90min-1 week

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,556 Previous Clinical Trials
1,822,241 Total Patients Enrolled
61 Trials studying Obsessive-Compulsive Disorder
13,242 Patients Enrolled for Obsessive-Compulsive Disorder
Rebecca PriceLead Sponsor
5 Previous Clinical Trials
450 Total Patients Enrolled
Rebecca B Price, PhDPrincipal InvestigatorUniversity of Pittsburgh
1 Previous Clinical Trials
200 Total Patients Enrolled

Eligibility Criteria

Age 18 - 60 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are between the ages of 18 and 60 years.
References

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