This trial is evaluating whether VSL #3 112.5 Capsule will improve 1 primary outcome and 4 secondary outcomes in patients with Liver Diseases, Alcoholic. Measurement will happen over the course of Baseline to 6 months.
This trial requires 80 total participants across 2 different treatment groups
This trial involves 2 different treatments. VSL #3 112.5 Capsule is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"Alcoholic liver diseases are among the most frequent co-morbidities of chronic alcoholic hepatitis in the United States. Alcoholic liver diseases constitute the most common cause of acute liver failure in US alcoholic patients, and are the leading cause of death among this population." - Anonymous Online Contributor
"Most patients with alcoholic liver disease require medical treatment. Because of the lack of good clinical trials, the optimal intervention is not entirely clear. The goal is to prolong survival and to minimize complications such as hepatocellular carcinoma.\n" - Anonymous Online Contributor
"Signs of alcoholic liver diseases are those listed in the table. They are typically related to problems of digestion and absorption. Those signs associated with liver disease and steatosis and cirrhosis are more likely to have no obvious cause but are more likely to be reversed. The signs listed in the table are those to look for in patients attending hospitals due to problems of digestion and absorption.\n- Liver biopsy\n1. Signs of liver disease: raised liver enzymes, elevated gamma glutamyl transpeptidase (GGT) and bilirubin.\n2." - Anonymous Online Contributor
"Alcoholism is one of the most important risk factors for chronic liver diseases. On the other hand, cirrhosis and hepatocellular carcinoma share a common genetic background. Further, it appears that a chronic infection by HBV in chronic alcoholic patients may lead to higher incidence of these lesions. Thus, this study shows that alcoholism causes liver diseases. However, the mechanism by which it causes liver damage is not yet clear at the epidemiological level." - Anonymous Online Contributor
"Alcohol use can be a cause of alcoholic liver disease, because of chronic alcoholic hepatitis and cirrhosis. Alcohol can also exacerbate the course of alcohol-related liver diseases. The diagnosis and the early initiation of treatment are of great importance for the improvement of the outcome of alcoholic liver disease. Therefore, screening for cirrhosis and HBV at an early stage helps prevent progression and complications." - Anonymous Online Contributor
"The advances in research into alcoholic liver disease have led to progress in many pharmacologic and surgical alternatives for the treatment of this prevalent disease." - Anonymous Online Contributor
"In the absence of data from randomized controlled trials, there is no basis for recommending specific prescribing practices of GVS-3 in combination with other treatments. The conclusions from this sub-analysis are based on individual patient data." - Anonymous Online Contributor
"The safety and effectiveness profile for vsl capsule 112.5 in alcoholic men and post-menopausal women suggests that additional studies be conducted with this dose. The data also indicate that capsule 112.5 might have a role in the management of mild-to-moderate hepatic fibrosis." - Anonymous Online Contributor
"Moderate/severe alcoholic liver disease is a lethal condition. This is one of the most important determinants of mortality in patients with chronic alcohol abuse, and also in those who develop alcoholic hepatitis in the course of chronic alcohol abuse. Liver disease prevalence can be reduced by limiting alcohol in the population." - Anonymous Online Contributor
"Alcoholic liver disease is a common hereditary problem. To minimize the effect of familial alcohol consumption, the prevention plan of alcohol consumption ought to be strengthened. Patients are encouraged to detect early signs of liver diseases, such as asymptomatic hepatitis, and to get regular medical or dental check-ups." - Anonymous Online Contributor
"In South Korea, alcohol consumption predominates as the primary cause of liver diseases, especially alcoholic and viral causes. Alcohol-related liver diseases are the most important and potentially treatable diseases in general medicine." - Anonymous Online Contributor