rTMS for AUD+mTBI
(TMS_AUD+mTBI Trial)
Trial Summary
What is the purpose of this trial?
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder. The treatment intervention is repetitive Transcranial Magnetic Stimulation (rTMS) and the goal is to reduce alcohol craving with this treatment. The study will enroll 20 Veteran participants. Half of these participants will receive real rTMS and half of the participants will receive placebo rTMS. rTMS treatment will be provided over 10 sessions that will occur once every weekday for 2 weeks. Veteran participants will then complete follow-up phone calls to further evaluate alcohol craving and other symptoms.
Research Team
Amy A Herrold, PhD BA
Principal Investigator
Edward Hines Jr. VA Hospital, Hines, IL
Eligibility Criteria
This trial is for English-speaking Veterans aged 22-65 with alcohol use disorder (AUD) and mild traumatic brain injury or PTSD. They must pass an MRI safety screening, have specific AUDIT-C scores, and not be in severe alcohol withdrawal. Exclusions include severe TBI, psychotic disorders, seizure history, certain medication use, substance dependence other than alcohol, recent mild TBI or surgery involving the heart/brain vessels.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Repetitive Transcranial Magnetic Stimulation (rTMS) (Non-invasive Brain Stimulation)
Repetitive Transcranial Magnetic Stimulation (rTMS) is already approved in Canada, Japan for the following indications:
- Depression
- Depression
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor