Study Summary
This trial will focus on improving the health of older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to improve vascular endothelial function.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
3 Primary · 0 Secondary · Reporting Duration: Baseline, months 3 and 6, and every 6 months thereafter until the end of year 4.
Year 4
Respiration
Change in Flow Mediated Dilation (FMD)
Leg
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Exercise Rehabilitation
1 of 2
Exercise Rehabilitation with Placebo
1 of 2
Experimental Treatment
Non-Treatment Group
300 Total Participants · 2 Treatment Groups
Primary Treatment: Mitoquinone · Has Placebo Group · N/A
Exercise RehabilitationExperimental Group · 2 Interventions: Mitoquinone, Placebo · Intervention Types: DietarySupplement, DietarySupplement
Exercise Rehabilitation with PlaceboPlaceboComparator Group · 2 Interventions: Mitoquinone, Placebo · Intervention Types: DietarySupplement, DietarySupplement
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mitoquinone
2018
Completed Phase 2
~10
Placebo
1995
Completed Phase 3
~2670
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, months 3 and 6, and every 6 months thereafter until the end of year 4.
Who is running the clinical trial?
VA Office of Research and DevelopmentLead Sponsor
1,483 Previous Clinical Trials
2,741,767 Total Patients Enrolled
Joel Douglas Trinity, PhDPrincipal InvestigatorVA Salt Lake City Health Care System, Salt Lake City, UT
1 Previous Clinical Trials
76 Total Patients Enrolled
Eligibility Criteria
Age Any Age · All Participants · 4 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You are eligible for this study if you are 50 years of age or greater.
You are a patient with SARS-CoV-19 who has a positive test near the time of diagnosis.
You have been diagnosed with COVID-19 and have recovered
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Conditions
Cancer Related
Treatments