Accelerated Radiation for Breast Cancer
(ART Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This protocol is for patients with newly diagnosed breast cancer with an indication for post-operative radiotherapy after neo-adjuvant chemotherapy and surgery.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it does allow for anti HER2neu therapies during the study. It's best to discuss your specific medications with the trial team.
Is accelerated radiation therapy safe for breast cancer patients?
How does Accelerated Radiation Therapy (ART) differ from other breast cancer treatments?
Accelerated Radiation Therapy (ART) for breast cancer is unique because it targets only the area around the tumor site, reducing the treatment time from several weeks to just a few days. This approach, known as accelerated partial breast irradiation, minimizes exposure to healthy tissue and is particularly beneficial for early-stage breast cancer patients.26789
What data supports the effectiveness of the treatment Accelerated Radiation Therapy (ART) for breast cancer?
Research shows that accelerated partial breast irradiation, a form of accelerated radiation therapy, is effective for early-stage breast cancer, offering similar outcomes to whole breast radiation with fewer side effects. Short courses of radiation therapy over 3-4 weeks are generally as effective as longer courses, and modern techniques have improved safety and survival rates.26101112
Who Is on the Research Team?
Silvia Formenti
Principal Investigator
Weill Cornell Medicine - New York Presbyterian Hospital
Are You a Good Fit for This Trial?
This trial is for women over 18 with Stage I-III breast cancer who've had neo-adjuvant chemotherapy and surgery. They must understand the study and agree to participate. Excluded are pregnant or breastfeeding women, those with more than 5 affected lymph nodes, previous radiation in the same area, active connective tissue disorders like lupus, or concurrent chemotherapy (except anti HER2neu therapies).Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation Therapy
Participants receive radiation therapy to the breast and nodal stations, including a concomitant boost for some patients
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of acute and late radiation toxicity and quality of life
Long-term Monitoring
Molecular signatures predicting fibrosis are measured from blood samples
What Are the Treatments Tested in This Trial?
Interventions
- Accelerated Radiation Therapy (ART)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Weill Medical College of Cornell University
Lead Sponsor