Constipation Clinical Trials 2023

What Are Constipation Clinical Trials?

Constipation may not seem like a major condition to worry about, but clinical trials have always been at the heart of most medical advances, no matter the condition in question. These trials aim to study different complications that may be caused by constipation. They also take into account the long-term outcomes of treatments for chronic constipation.

Why Is Constipation Being Studied Through Clinical Trials?

Constipation can cause many complications, such as problems related to bowel consistency, abdominal pain, bowel habits, and much more. Furthermore, long-term constipation can also result in fecal impaction, piles, leakage of liquid stools, and much more. By studying the condition and its existing treatments through clinical trials, researchers can determine cost-effective, safe, and effective methods to deal with it.

What Types of Treatments Are Available for Treating Constipation?

Constipation can go away by incorporating certain lifestyle changes. In many cases, laxatives are also prescribed to make it easier to have bowel movements. These laxatives can include stool softeners, osmotic, stimulants, and fiber supplements. In rare cases, surgery is also performed, given that none of the other treatments have worked and the constipation is a result of a blockage or structure.

What Are Some Recent Breakthrough Clinical Trials for Constipation?

Here are some studies that highlight major breakthroughs in constipation clinical trials.

Tegaserod Treatment For Chronic Constipation, 2007 – The study aimed to evaluate the safety and efficacy of a drug called tegaserod in both women and men with chronic constipation from China. Since it was a placebo-controlled study, it was conducted following a 2-week treatment-free period. After this, patients were divided into two groups, one that received tegaseriod (6 mg) and another that received a placebo. The results concluded that tegaserod treatment improved a number of chronic constipation symptoms, and it also had a better safety profile.

Opioid-Induced Constipation Is Reversible - Most cancer patients have no choice but to take opioids for pain. As a result, they also have to deal with chronic constipation. However, through this research, they may no longer have to deal with the chronic constipation side effect. Researchers from the University of the Pacific found that certain receptors in the brain are responsible for this type of constipation. Hence, they tried coming up with an approach that didn’t directly affect the brain, resulting in the patient staying pain-free.

Who Are Some Of The Key Research Institutions Conducting Constipation Clinical Trial Research?

Thomas J. Long School of Pharmacy at the University of the Pacific has a team of dedicated researchers who have been trying to figure out ways to improve patient well-being through extensive research. Their recent findings about opioid-induced constipation have helped determine ways to treat cancer while being mindful of the side effects associated with opioids.

The Innovative Clinical and Outcomes Research (iCOR) team at the university is also providing exposure to students so they can collaborate with faculty and peers to work on high-impact research projects.