Constipation Clinical Trials
Here are the 6 most popular medical studies for constipation
Procedure
Transdermal Administration by a Novel Wireless Iontophoresis Device for Bowel Incontinence
This trial aims to develop a new method to treat bowel dysfunction in individuals with spinal cord injury. The researchers have created a dual drug combination that can help safely and predictably empty the bowels. They
Laxative
Polyethylene Glycol 3350 for Uterine Prolapse
This trial aims to see if giving women a laxative before surgery for pelvic prolapse reduces discomfort with bowel movements after surgery. Participants will complete questionnaires before and after surgery to compare the effects of using
Behavioural Intervention
Constipation treatment for Constipation
This trial aims to study the effects of constipation treatment on patients with chronic kidney disease. Researchers want to see if treating constipation can improve kidney and heart health outcomes and if it has any impact on
Popular filter options for constipation trials
Irritable Bowel Syndrome Clinical Trials
View 10 Irritable Bowel Syndrome medical studies.
Small Molecule Inhibitor
Tenapanor for Irritable Bowel Syndrome
This trial aims to understand how a medication called tenapanor affects the gut bacteria and chemicals in patients with irritable bowel syndrome with constipation (IBS-C). Tenapanor is a new medication
Guanylate Cyclase-C Agonist
Long-Term Safety of Linaclotide for Constipation
This trial will enroll children who have completed other trials testing the drug linaclotide for constipation or irritable bowel syndrome with constipation. The children will take the drug for 24 or 52 weeks depending on the condition.
Behavioural Intervention
Low FODMAP Diet + PEG 3350 for IBS with Constipation
This trial will test the efficacy of PEG 3350 + a diet low in fermentable oligo, di, monosaccharides, and polyols (FODMAP) vs. PEG 3350 plus sham diet for Irritable Bowel Syndrome with Constipation (IBS-C).
Phase 3 Constipation Clinical Trials
View 42 phase 3 constipation medical studies.
Probiotic
Multistrain Probiotic for Constipation
Subjects will be screened and will enter a placebo-only 2-week run-in period during which constipation symptoms will be evaluated and any disallowed products (e.g. probiotics) must be discontinued. Following successful completion of the run-in period, subjects will be randomized to probiotic (high or low-dose groups) or placebo. Subjects will then consume their assigned product daily for 6 weeks. Subjects will undergo abdominal x-rays on study days 0 and 42 to assess transit time with each examination preceded by 6 days of radiopaque Sitz marker ingestion. Subject diaries will be used to collect bowel movement frequency, stool consistency, concomitant medications, and adverse events each day during the trial. Stool samples will be collected at baseline and end of study to assess fecal probiotic count. PAC-QOL, WCS, and GSRS questionnaires will be administered at baseline and day 42. 24-hour food recalls will be administered at day 0 and 42 and the following parameters will be assessed: total calories, carbohydrate, fat, protein, fiber, and liquid intake. Weekly physical activity recalls will be completed.
Opioid Antagonist
Methylnaltrexone Bromide +1 More for Constipation
The purpose of this study is to determine if there will be a significantly higher incidence of a bowel movement with methylnaltrexone vs. placebo within 4 hours +- 45 minutes with decreased need for rescue medications in the intensive care unit in patients with opioid-induced constipation. Patients will also be managed with an aggressive bowel management protocol.
Guanylate Cyclase-C Agonist
Linaclotide for Pediatric Constipation
This trial will assess the safety and effectiveness of Linaclotide for children with functional constipation. Kids will take Linaclotide or placebo for 12 weeks, then switch to Linaclotide for 24 weeks. Medical assessments, tests and questionnaires will be used to check the effect of the treatment.
View More Constipation Trials
See another 18 medical studies focused on constipation.
Frequently Asked Questions
Introduction to constipation
What are the top hospitals conducting constipation research?
When it comes to addressing the common condition of constipation, several top hospitals are leading the way in clinical trials. In Anaheim, California, the Advanced Research Center is making strides with three ongoing constipation trials and a total of three completed studies. While this may seem relatively recent compared to other institutions, they have already made significant progress since recording their first constipation trial in 2021. The University of Michigan in Ann Arbor is also actively researching solutions for constipation with three current trials and a history of six previous studies dating back to 2014.
Heading east to Boston's renowned Massachusetts General Hospital, two active constipation trials are underway alongside an impressive track record of eleven completed investigations since their initial involvement in 2006. Similarly dedicated to advancing knowledge and treatment options for constipation, Mayo Clinic in Rochester has two ongoing clinical trials and five previously conducted studies on record since their inaugural trial in 2011.
Even smaller-scale institutions like G & L Research LLC located in Foley, Alabama play a crucial role. They currently have two active constipation trials underway while having contributed significantly over the years through three previously held investigations; their first recorded participation dates back only as far as 2015.
These dedicated hospitals exemplify our collective commitment towards understanding and finding effective solutions for those who suffer from chronic or occasional bouts of constipation. Through groundbreaking research initiatives like these clinical trials, we can gain valuable insights that pave the way for improved treatments and better quality of life for individuals affected by this common yet often underestimated condition
Which are the best cities for constipation clinical trials?
When it comes to constipation clinical trials, several cities are at the forefront of research. Miami, Florida leads with 21 active trials investigating treatments like Linaclotide and Prucalopride. Houston, Texas follows closely behind with 12 ongoing studies focused on Prucalopride and linaclotide. Denver, Colorado also shows promise in constipation research with 11 active trials exploring various treatments. These cities offer individuals experiencing constipation access to cutting-edge clinical trials that may lead to advancements in treatment options and ultimately improve quality of life.
Which are the top treatments for constipation being explored in clinical trials?
Promising treatments for constipation are making strides in clinical trials. One notable contender is Transcutaneous Electrical Acustimulation (TEA), currently undergoing one active trial and two all-time constipation trials since its introduction in 2021. PEG 3350, another noteworthy option, is being explored in one active trial and boasts four all-time constipation trials since 2006. Additionally, Fecobionics shows potential with one ongoing trial and two all-time constipation studies since its listing in 2017. These innovative approaches offer hope for individuals dealing with the challenges of constipation, pushing forward research efforts to find effective solutions.
What are the most recent clinical trials for constipation?
Recent clinical trials have brought new possibilities for the management of constipation. One notable trial investigated the efficacy of PEG 3350, a treatment option that reached Phase 4 and became available on 6/8/2023. Additionally, another Phase 4 intervention focused specifically on addressing constipation also became available on 6/1/2023. In parallel, research is underway to assess the potential benefits of linaclotide in treating constipation through two distinct phases: Part 2 (Phase 2), which emerged on 4/27/2023, and Part 1 (Phase 3) released on12/29/2022. Another promising development is tenapanor, currently in Phase three since it became accessible on February17th,2023.Through these diverse studies conducted at varying stages, clinicians endeavor to improve outcomes for individuals grappling with constipation by expanding our understanding and refining treatment options.
What constipation clinical trials were recently completed?
Recently, a clinical trial focusing on constipation investigated the potential of Pradigastat Tablets 40mg. Sponsored by Anji Pharma, this trial was successfully completed in September 2020. The results of this study contribute valuable insights into the management and treatment options for individuals experiencing constipation.