Glutamine for Indigestion
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether glutamine, an important amino acid, can improve symptoms of functional dyspepsia, a type of chronic indigestion. Participants will receive either glutamine or a placebo (a harmless pill with no active ingredients) for 28 days to assess differences in symptom relief and safety. Individuals with ongoing stomach discomfort that meets the criteria for functional dyspepsia, and who are generally healthy, might be suitable candidates. As a Phase 1, Phase 2 trial, this research aims to understand how the treatment works in people and measure its effectiveness in an initial, smaller group.
Will I have to stop taking my current medications?
You may need to stop taking certain medications like proton pump inhibitors (PPIs), opioids, corticosteroids, daily antihistamines, NSAIDs, or mast-cell stabilizing agents at least 2 weeks before joining the trial. If you're on PPIs, you can switch to famotidine 20 mg daily for 2 weeks before enrolling.
Is there any evidence suggesting that glutamine is likely to be safe for humans?
A previous study found that patients who received glutamine after stomach surgery tolerated it well and experienced no major side effects. Only a few participants (3 out of 14) reported minor issues such as nausea, hiccups, or gas. This indicates that glutamine is generally safe. As an important nutrient for the gut, glutamine helps maintain the strength of the intestinal wall, which could benefit individuals with functional dyspepsia, a type of indigestion. Since this trial is in its early stages, it primarily focuses on safety, and the study's findings suggest that glutamine is generally safe to use.12345
Why do researchers think this study treatment might be promising for indigestion?
Unlike the typical treatments for indigestion, which often include antacids or proton pump inhibitors, glutamine offers a unique approach by potentially enhancing gut health and repairing the intestinal lining. Researchers are excited about glutamine because it is a naturally occurring amino acid in the body, which might lead to fewer side effects compared to traditional medications. Additionally, its ability to support the integrity of the intestinal barrier could offer a more holistic improvement in digestive health, making it a promising option for those seeking alternatives to conventional indigestion remedies.
What evidence suggests that glutamine might be an effective treatment for indigestion?
Research has shown that glutamine can improve digestive health. Studies have found that it strengthens the gut wall by reducing its permeability, which might alleviate symptoms like stomach pain and discomfort. In this trial, participants in the Glutamine Group will receive glutamine for 28 days to evaluate its effects on digestive symptoms. Overall, these findings suggest that glutamine might benefit people with functional dyspepsia, a condition causing indigestion and stomach discomfort.12467
Who Is on the Research Team?
David Cangemi, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for people in good health with functional dyspepsia, which causes indigestion. They must fit the Rome IV criteria for this condition and can't have allergies to certain sugars, liver or kidney problems, be pregnant or breastfeeding, use tobacco heavily, drink excessively, or have had recent stomach surgery.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either glutamine or placebo for 28 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Glutamine
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
David J. Cangemi
Lead Sponsor