Sibo Clinical Trials 2023

What Are Sibo Clinical Trials?

Small intestinal bacterial overgrowth (SIBO) is a serious condition when the patient has excessive bacteria in their small intestine. Some patients may also contain certain types of bacteria not part of the digestive tract. The condition is also referred to as blind loop syndrome.

SIBO often occurs when a disease or surgery disrupts the movement of food and waste products in the digestive tract, creating ideal conditions for bacteria to exist. The presence of bacteria in the small intestine usually triggers excessive diarrhea, gas, and other byproducts. The condition is highly prevalent among people, and the exact cause is unknown, thus necessitating more SIBO clinical trials to aid in accurate diagnosis and treatment.

Why Is Sibo Being Studied Through Clinical Trials?

The majority of symptoms of SIBO overlap with other conditions, and it is common for doctors not to recognize the ailment. It is difficult to diagnose SIBO because most moderate cases feature non-specific symptoms in other gastrointestinal conditions. Further SIBO clinical trials are needed to study its exact causes, risk factors, and common food triggers.

What Are The Types of Treatments Available For Sibo?

The most common treatment for SIBO is to improve gut health. This should ease patient symptoms and help their body absorb more nutrients from food. Treatments for Sibo also depend on the patient’s breath test. For example, if the breath test shows a high presence of methane, the doctor may prescribe rifaximin and neomycin. And if the sample yields high quantities of hydrogen, the doctor may only prescribe rifaximin.

Patients may also be prescribed other antibiotics such as Amoxicillin-clavulanic acid, Metronidazole, Norfloxacin, and Ciprofloxacin.

For mild cases of SIBO, the patient may be asked to make dietary changes by cutting sugary foods and drinks for three days to see if the symptoms improve. This helps the patient learn about food groups that trigger SIBO.

What Are Some Recent Breakthrough Clinical Trials For Sibo?

The following clinical trials for SIBO have paved the way for more effective treatment methods and help doctors understand the condition more thoroughly.

2010: Using Rifaximin with Guar Gum - This SIBO clinical trial of 77 patients sought to prove that rifaximin, in conjunction with hydrolyzed guar gum, improved the condition.

2019: The Clinical Impact of SIBO in Patients with CF - This study aimed to explore the correlation between SIBO and cystic fibrosis. It concluded that patients with cystic fibrosis had a higher prevalence of SIBO and that rifaximin can play a role in treating the condition.

Who Are Some of The Key Opinion Leaders and Institutions Conducting Sibo Clinical Trial Research?

Manuele Furnari is an associate professor at Universita di Genova in Italy and has published several studies on SIBO.

Stanford Medicine has a dedicated department of research for intestinal bacterial overgrowth and has conducted several clinical trials on patients with SIBO to see how they respond to different treatments.