Pre-Treatment Physical Therapy for Acoustic Neuroma
(VS PREHAB Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The study is a pilot efficacy study. The investigators aim to estimate mean baseline and post-treatment balance scores among Vestibular Schwannomas (VS) patients undergoing pretreatment rehab (PREHAB) or no PREHAB when managed with either surgery or radiosurgery.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
Is pre-treatment physical therapy for acoustic neuroma safe?
Research shows that stereotactic radiosurgery and fractionated stereotactic radiotherapy for vestibular schwannoma (a type of acoustic neuroma) are generally safe, with low rates of side effects (1-7%). These treatments are effective in controlling tumor growth and are considered safe options for managing this condition.12345
How does pre-treatment physical therapy for acoustic neuroma differ from other treatments?
Pre-treatment physical therapy for acoustic neuroma is unique because it involves preparing patients for either microsurgical resection or stereotactic radiosurgery, which are precise, non-invasive treatments that target the tumor with high accuracy. This approach can help improve outcomes by potentially reducing the side effects and enhancing recovery compared to traditional surgical methods.16789
What data supports the effectiveness of this treatment for acoustic neuroma?
Research shows that stereotactic radiosurgery and fractionated stereotactic radiotherapy are effective treatments for controlling vestibular schwannoma (acoustic neuroma) with high tumor control rates around 90% and low side effects. Additionally, CyberKnife radiotherapy has shown a 77% hearing preservation rate at 2 years, making it a practical and effective option for patients.137810
Who Is on the Research Team?
Michael Harris, MD
Principal Investigator
Medical College of Wisconsin
Are You a Good Fit for This Trial?
Adults diagnosed with Vestibular Schwannoma (VS) of size β€2.5 cm, confirmed by MRI, who will undergo surgery or radiosurgery. Participants must be in good health as determined by normal lab values and have an ECOG Performance Status <2. Pregnant women or those not using effective contraception are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Treatment Rehabilitation
Participants undergo PREHAB exercises including balance, gaze stabilization, and habituation exercises prior to surgery or radiosurgery
Treatment
Participants receive either microsurgical resection or stereotactic radiosurgery for vestibular schwannomas
Follow-up
Participants are monitored for safety and effectiveness after treatment, with primary endpoint measured at 12 months post-treatment
What Are the Treatments Tested in This Trial?
Interventions
- Microsurgical resection of VS
- PREHAB
- Stereotactic radiosurgery
Microsurgical resection of VS is already approved in European Union, United States, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor