200 Participants Needed

Peer-Delivered Behavioral Activation for Opioid Addiction

(HEAL Together Trial)

Recruiting at 1 trial location
VD
AG
Overseen ByAaron Greenblatt, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Maryland, College Park
Must be taking: Methadone
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests if trained peers can help low-income, minority individuals with opioid addiction stick to their medication by encouraging positive activities. The goal is to see if this approach improves medication adherence.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it focuses on improving adherence to methadone, a medication for opioid use disorder. It seems likely that you will continue taking methadone during the study.

Is Peer-Delivered Behavioral Activation safe for humans?

The research does not specifically mention safety concerns related to Peer-Delivered Behavioral Activation, suggesting it is generally considered safe when delivered by trained peer recovery specialists.12345

How is the Peer-Delivered Behavioral Activation treatment different from other treatments for opioid addiction?

This treatment is unique because it involves peer recovery specialists, who have personal experience with addiction and recovery, delivering behavioral activation therapy to support patients in methadone treatment, aiming to improve retention by addressing stigma and providing relatable support.13567

What data supports the effectiveness of the treatment Peer-Delivered Behavioral Activation for Opioid Addiction?

Research suggests that peer recovery specialists, who have personal experience with substance use and recovery, can effectively deliver behavioral activation (a therapy that helps people engage in positive activities) to support patients in methadone treatment for opioid addiction. This approach, called Peer Activate, has shown promise in improving retention in treatment, which is crucial for recovery success.13689

Who Is on the Research Team?

JF

Jessica F Magidson, PhD

Principal Investigator

University of Maryland, College Park

Are You a Good Fit for This Trial?

This trial is for adults over 18 in Baltimore with opioid use disorder who have started methadone treatment at the study site within the last three months or have had trouble sticking to their methadone regimen. It's not for those with untreated severe mental health issues, non-English speakers, or pregnant individuals.

Inclusion Criteria

I started methadone recently or had trouble following my methadone treatment.

Exclusion Criteria

Inability to understand the study and provide informed consent in English
Demonstrating active, unstable or untreated psychiatric symptoms, including mania and/or psychosis that would interfere with study participation
Positive pregnancy status at enrollment

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a peer-delivered behavioral activation intervention to improve adherence to methadone treatment

6 months
Weekly sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months

What Are the Treatments Tested in This Trial?

Interventions

  • Peer-Delivered Behavioral Activation
Trial Overview The 'Peer Activate' program, led by peer recovery specialists using behavioral activation techniques, aims to improve how well participants stick to their medication-assisted treatment for opioid addiction compared to usual care. The effectiveness and implementation will be studied over six months.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Peer-Delivered Behavioral Activation ("Peer Activate")Experimental Treatment1 Intervention
Participants in the Peer Activate intervention will receive a PRS-delivered behavioral activation intervention to address barriers to retention in methadone treatment and increase substance-free, positive reinforcement to support retention.
Group II: Treatment As UsualActive Control1 Intervention
Participants in the TAU group will receive treatment as usual (weekly group and individual counseling with an addiction counselor in addition to referral to other available services in the community through study contact).

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Maryland, College Park

Lead Sponsor

Trials
163
Recruited
46,800+

Henry Ford Health System

Collaborator

Trials
334
Recruited
2,197,000+

University of Maryland, Baltimore

Collaborator

Trials
729
Recruited
540,000+

Published Research Related to This Trial

A qualitative study involving 26 patients receiving methadone treatment found that a peer recovery specialist-delivered behavioral activation intervention (Peer Activate) was perceived as acceptable and feasible, particularly due to its flexibility and the supportive qualities of the peer specialists.
Participants highlighted the importance of connecting with the intervention content and building skills, while also noting stigma related to substance use and methadone treatment as barriers to engagement, suggesting that addressing these issues could enhance treatment retention.
"You rise up and then you start pulling people up with you": Patient experiences with a peer-delivered behavioral activation intervention to support methadone treatment.Kleinman, MB., Hines, AC., Anvari, MS., et al.[2023]
The Peer Activate intervention, delivered by peer recovery specialists, showed high feasibility and acceptability, with 86.5% of participants initiating the program and 81.3% completing at least 75% of sessions, indicating strong engagement among low-income, minoritized populations.
Participants in the Peer Activate program had a significantly higher retention rate in methadone treatment (88.6%) compared to those receiving standard treatment, along with improved adherence to methadone and reduced substance use frequency, highlighting the potential effectiveness of this approach.
Peer recovery specialist-delivered, behavioral activation intervention to improve retention in methadone treatment: Results from an open-label, Type 1 hybrid effectiveness-implementation pilot trial.Magidson, JF., Kleinman, MB., Bradley, V., et al.[2023]
Patient activation, which involves actively participating in treatment decisions and taking responsibility for recovery, is crucial for positive outcomes in individuals with opioid use disorder (OUD) in intensive outpatient treatment (IOT) programs, as identified through interviews with 14 participants.
The study identified six key types of patient activation behaviors, highlighting the importance of collaboration with staff and self-determination in recovery, suggesting that IOT programs should foster these active roles while being cautious about the timing of certain interventions to avoid hindering recovery.
Patient Activation of Persons With Opioid Use Disorder in Intensive Outpatient Treatment.Keen, A., Lu, Y., Oruche, UM., et al.[2022]

Citations

"You rise up and then you start pulling people up with you": Patient experiences with a peer-delivered behavioral activation intervention to support methadone treatment. [2023]
Peer recovery specialist-delivered, behavioral activation intervention to improve retention in methadone treatment: Results from an open-label, Type 1 hybrid effectiveness-implementation pilot trial. [2023]
Patient Activation of Persons With Opioid Use Disorder in Intensive Outpatient Treatment. [2022]
Emergency department-based peer support for opioid use disorder: Emergent functions and forms. [2021]
Effectiveness of peer recovery support services on stages of the opioid use disorder treatment cascade: A systematic review. [2022]
Real-world reduction in healthcare resource utilization following treatment of opioid use disorder with reSET-O, a novel prescription digital therapeutic. [2022]
A Peer Recovery Coach Intervention for Hospitalized Patients with Opioid Use Disorder: A Pilot Randomized Controlled Trial. [2023]
Feasibility and outcomes from an integrated bridge treatment program for opioid use disorder. [2022]
"In their mind, they always felt less than": The role of peers in shifting stigma as a barrier to opioid use disorder treatment retention. [2023]
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