Pyridostigmine for HIV/AIDS

Phase-Based Progress Estimates
Icahn School of Medicine at Mount Sinai, New York, NYHIV/AIDS+2 MorePyridostigmine - Drug
All Sexes
What conditions do you have?

Study Summary

This trial will study whether a medication and nerve stimulation can help treat inflammation in people with HIV.

Eligible Conditions
  • Vagus Nerve Dysfunction
  • Non-HIV Related Immunodeficiency

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 0 Secondary · Reporting Duration: 5 years

5 years
Gastric pH measurement
Hydrogen/methane breath testing (hbt)
IL6 measurement. [Time Frame: 5 years]
Small bowel transit time (SBTT)

Trial Safety

Safety Progress

1 of 3

Trial Design

4 Treatment Groups

Healthy Controls
1 of 4
1 of 4
1 of 4
1 of 4

Active Control

Non-Treatment Group

150 Total Participants · 4 Treatment Groups

Primary Treatment: Pyridostigmine · Has Placebo Group · Phase 1 & 2

Healthy ControlsNoIntervention Group · 1 Intervention: Healthy Controls · Intervention Types:
ActiveComparator Group · 1 Intervention: Pyridostigmine · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Placebos · Intervention Types: Drug
PLWHNoIntervention Group · 1 Intervention: PLWH · Intervention Types:

Trial Logistics


Participation is compensated

You will be compensated for participating in this trial.

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 5 years

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor
790 Previous Clinical Trials
508,809 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,184 Previous Clinical Trials
4,089,653 Total Patients Enrolled
Jessica Robinson-Papp, MDPrincipal Investigator - Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai
4 Previous Clinical Trials
362 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You do not have any medical conditions that affect your digestion or autonomic nervous system, except for HIV. Examples of such conditions are Parkinson's disease, diabetes, peptic ulcer disease, and infectious diarrhea.
You cannot take certain medications that have strong effects on your digestive system or nervous system, such as drugs that speed up your heart rate, promote digestion, or reduce diarrhea.

Frequently Asked Questions

In what situations is Pyridostigmine generally utilized?

"Pyridostigmine is used to manage symptoms of myasthenia gravis, dyschezia, orthostatic syncope, and non-depolarizing neuromuscular blocking agents." - Anonymous Online Contributor

Unverified Answer

Could you share the aggregate figure of participants enrolled in this research endeavor?

"Indeed, attests that this research project is actively recruiting participants. This trial was published on August 3rd 2020 and has since been modified on April 12th 2022. The study necessitates 250 test subjects from a single medical site." - Anonymous Online Contributor

Unverified Answer

Is enrollment for this experiment currently available to participants?

"Affirmative. According to information hosted on, this study is presently seeking participants--the trial was first published on August 3rd 2020 and the most recent update occurred on April 12th 2022. The experiment has allocated 250 slots across one medical site." - Anonymous Online Contributor

Unverified Answer

Are there pre-existing studies that utilize Pyridostigmine?

"At present, 4 clinical trials investigating the effects of Pyridostigmine are being conducted. Unfortunately, none of these investigations have advanced to Phase 3. Nevertheless, individuals in Nashville, Tennessee and its surrounding areas can access numerous research sites that offer this medical intervention." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.