FMT + SIMBA for Obsessive-Compulsive Disorder
(FOCUSED Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing whether transferring healthy gut bacteria to people with OCD can help those who don't benefit from current treatments. Researchers will compare traditional methods with a new approach to see how the transplant affects the gut and brain. This technique has a long history and is currently being used to treat various conditions, including digestive disorders.
Will I have to stop taking my current medications?
The trial requires participants to be on a stable dose of an SSRI (a type of antidepressant) for at least 12 weeks before starting. However, you cannot regularly take antibiotics, prebiotics, or probiotics during the trial.
How does the FMT Capsule treatment for OCD differ from other treatments?
FMT Capsule treatment for OCD is unique because it involves the use of fecal microbiota transplantation (FMT), which is not a standard approach for OCD. This treatment focuses on altering the gut microbiome, which is a novel mechanism compared to traditional therapies like cognitive-behavioral therapy or medications that target brain chemistry.12345
Who Is on the Research Team?
Valere Taylor, MD,PhD,FRCPC
Principal Investigator
Professor, Head of Department
Are You a Good Fit for This Trial?
This trial is for adults with OCD who haven't had enough improvement from their current SSRI treatment. They must have been on a stable dose for at least 12 weeks and not be suicidal or diagnosed with certain digestive diseases like IBD, Crohn's, Ulcerative colitis, or Celiac disease. They can't be immune-suppressed, pregnant, breastfeeding, planning to get pregnant during the study, regularly taking antibiotics/prebiotics/probiotics, have swallowing disorders or meet criteria for substance use/eating disorder/schizophrenia.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive FMT capsules as an adjunct treatment to their approved first line OCD medication
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- FMT Capsule
Find a Clinic Near You
Who Is Running the Clinical Trial?
Valerie Taylor
Lead Sponsor
Nimble Science Ltd.
Industry Sponsor
University of Calgary
Collaborator