← Back to Search

Behavioural Intervention

Accelerated Brain Stimulation for Depression (MediTMS Trial)

N/A

Recruiting

Led By Jyoti Mishra, PhD

Research Sponsored by University of California, San Diego

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Moderate to severe depression (PHQ-9 scale score >9 with confirmation using the Structured Clinical Interview for DSM-5 Disorders)

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 6 weeks

Awards & highlights

MediTMS Trial Summary

This trial is testing a next-generation rTMS protocol that is guided by principles of brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression.

Who is the study for?

This trial is for adults with moderate to severe depression who haven't had success with 1-3 antidepressants or can't tolerate them. Participants should not have active substance abuse, psychotic disorders, metal implants in the brain, history of stroke or seizures, and shouldn't be at immediate risk of suicide.Check my eligibility

What is being tested?

The study tests a new rTMS protocol that aims to improve brain plasticity and treat depression more effectively. It involves magnetic stimulation pulses on a specific part of the brain while patients are in a state of internal attention related to their condition.See study design

What are the potential side effects?

rTMS may cause discomfort at the stimulation site, headache, lightheadedness, or tingling. Rarely it could lead to seizures or hearing loss if ear protection isn’t used during treatment.

MediTMS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with moderate to severe depression.

MediTMS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 6 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 6 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from baseline Clinical Depression (Remission)

Change from baseline brain activity in attention-to-breath task

MediTMS Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Medi1TMSExperimental Treatment1 Intervention

rTMS theta-burst protocol paired with a consistent attention-to-breath task

Group II: Medi2TMSActive Control1 Intervention

rTMS theta-burst protocol paired with an intermittent deep breathing task

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor

1,123 Previous Clinical Trials

1,552,789 Total Patients Enrolled

29 Trials studying Depression

56,128 Patients Enrolled for Depression

Jyoti Mishra, PhDPrincipal Investigator - University of California, San Diego

University of California, San Diego

3 Previous Clinical Trials

96 Total Patients Enrolled

1 Trials studying Depression

40 Patients Enrolled for Depression

Media Library

Meditation Accelerated Brain Stimulation (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04586699 — N/A

Depression Research Study Groups: Medi2TMS, Medi1TMS

Depression Clinical Trial 2023: Meditation Accelerated Brain Stimulation Highlights & Side Effects. Trial Name: NCT04586699 — N/A

Meditation Accelerated Brain Stimulation (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04586699 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research program open to individuals aged 45 and above?

"Applicants must be between 18 and 65 years of age to qualify for this medical trial, as per the provided eligibility criteria."

Answered by AI

Are there any eligibility criteria for volunteers participating in this clinical experiment?

"This study is seeking 50 individuals aged 18 to 65 suffering from moderate-to-severe depression, as assessed by the PHQ-9 scale score and a Structured Clinical Interview for DSM-5 Disorders. Additionally, candidates must have tried 1 to 3 antidepressants that failed or 2 inadequate doses/durations of antidepressant during their current episode in order to be eligible."

Answered by AI

Is this experiment enrolling participants presently?

"Yes, current information on clinicaltrials.gov verifies this trial is actively enrolling patients. This medical study was initially posted to the website on July 15th 2021 and updated most recently on July 14th 2022. The research team seeks 50 volunteers across two sites for participation in the project."

Answered by AI

How many participants have been included in this research endeavor?

"Affirmative, the information provided by clinicaltrials.gov demonstrates that this research study is currently recruiting patients. The trial was initially posted on July 15th 2021 and has most recently been updated on July 14th 2022, aiming to enroll 50 people at two separate locations."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Meditation Accelerated Brain Stimulation for Depression

Jyoti Mishra 2021. "Meditation Accelerated Brain Stimulation for Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04586699.

All > Depression Anaheim > Treatment Resistant Depression