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Vitamin Supplement

Post-CABG patients with Thiamine Treatment Intervention. for Coronary Artery Bypass Surgery (B1&CABG Trial)

N/A

Waitlist Available

Led By Rajesh Kumar, PhD

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 1 month after cabg.

Awards & highlights

B1&CABG Trial Summary

This trial aims to investigate how heart disease patients undergoing a specific heart surgery may experience changes in the brain leading to memory and thinking problems. The study will also explore if a simple and inexpensive vitamin supplement called

Who is the study for?

This trial is for individuals with coronary heart disease who are scheduled to undergo coronary artery bypass grafting (CABG). Participants should be interested in exploring if thiamine can help reduce cognitive issues after surgery.Check my eligibility

What is being tested?

The study is testing whether taking thiamine, a vitamin B1 supplement, compared to a placebo (a substance with no active drug), can improve brain function and reduce cognitive deficits after CABG surgery in patients with CHD.See study design

What are the potential side effects?

Thiamine is generally considered safe and side effects are rare. However, some people might experience mild reactions like upset stomach or allergic responses. The placebo is inactive and typically does not have side effects.

B1&CABG Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and after 1 month after cabg.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and after 1 month after cabg.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and after 1 month after cabg. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Assessment of long term effects of thiamine treatment intervention on cognition in CABG patients after thiamine treatment.

Cognition assessment in CABG patients after thiamine treatment.

Effects of thiamine treatment intervention on blood inflammatory levels.

+9 more

B1&CABG Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Post-CABG patients with Thiamine Treatment Intervention.Experimental Treatment1 Intervention

Assess cognition and evaluate blood thiamine, lactate, and inflammatory marker levels in patients receiving thiamine intervention treatment within 5 days (baseline) and one month after CABG.

Group II: Post-CABG patients without Thiamine Treatment Intervention.Placebo Group1 Intervention

Assess cognition and evaluate blood thiamine, lactate, and inflammatory marker levels in patients receiving placebo treatment within 5 days (baseline) and one month after CABG.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Thiamine

2018

Completed Phase 4

~1620

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor

1,533 Previous Clinical Trials

10,265,516 Total Patients Enrolled

Rajesh Kumar, PhDPrincipal InvestigatorUniversity of California, Los Angeles

2 Previous Clinical Trials

57 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which individuals are eligible to participate in this research study?

"Prospective participants must present with coronary artery disease and fall within the age bracket of 60 to 80 years old in order to be considered for this clinical research. The trial aims to enroll a total of 52 individuals."

Answered by AI

Are there any vacancies available for patients to participate in this trial?

"The clinical trial mentioned is presently not seeking participants, as per information from clinicaltrials.gov. This specific study was initially posted on May 1st, 2024 and last updated on March 20th, 2024. Despite this particular trial being inactive in terms of recruitment, it's important to note that there are currently 799 other trials actively enrolling patients."

Answered by AI

Is there an age threshold for participation in this clinical trial, particularly regarding individuals above 35 years old?

"Participants eligible for this research project must fall within the age range of 60 to 80 years. There are a total of 108 trials targeting individuals below 18 and 716 studies focusing on those above 65."

Answered by AI

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