nTMS for Brain Metastasis Planning
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to evaluate how well nTMS (Navigated Transcranial Magnetic Stimulation) can assist in planning radiation treatment for individuals with brain metastases affecting the motor cortex, which controls muscle movement. Stereotactic radiosurgery delivers high radiation doses to combat cancer but may harm nearby brain areas. nTMS could enable doctors to target radiation more precisely, safeguarding critical muscle-control regions. The trial includes participants who have undergone radiation treatment for brain metastases in the past 3-18 months and can engage in nTMS and muscle testing. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance future treatment precision.
What prior data suggests that nTMS is safe for planning stereotactic radiosurgery?
Research has shown that navigated transcranial magnetic stimulation (nTMS) is generally safe and well-tolerated. In a study with 733 patients, nTMS mapping used before surgery did not cause any serious side effects. This non-invasive technique does not involve surgery or entering the body.
nTMS works by using sensors on muscles to locate the exact brain area controlling those muscles, aiding doctors in planning treatments more accurately. Other studies have also demonstrated that nTMS can be safely used for brain mapping during surgeries. Reports of negative effects were very few, indicating that it is a reliable and low-risk tool.12345Why are researchers excited about this trial?
Researchers are excited about using navigated Transcranial Magnetic Stimulation (nTMS) for planning stereotactic radiosurgery in brain metastasis patients because it offers a non-invasive way to map brain function. Unlike traditional imaging techniques, nTMS can precisely identify critical areas of the brain involved in motor and sensory functions, potentially enhancing the accuracy of treatment planning. This method could lead to fewer side effects and better preservation of brain function compared to existing options. By integrating sensory and motor testing, nTMS aims to provide a more comprehensive understanding of each patient's brain, which could personalize and improve the outcomes of radiosurgery treatments.
What evidence suggests that nTMS is effective for planning stereotactic radiosurgery in patients with brain metastases?
Research has shown that navigated Transcranial Magnetic Stimulation (nTMS) effectively maps the brain's motor cortex, which controls muscle movement. This technique helps doctors identify precise brain areas to avoid during surgery or radiation treatment, reducing the risk of damaging critical parts. Studies have demonstrated that nTMS can accurately guide brain surgeries by pinpointing areas to protect, especially in patients with brain tumors. In this trial, participants will undergo nTMS as part of the diagnostic arm to assess its utility in planning stereotactic radiosurgery, a type of radiation treatment. This approach aims to minimize harm to the motor cortex. While more research is needed, early results are promising for its use in planning treatment for brain metastases.14678
Who Is on the Research Team?
Caroline Chung
Principal Investigator
M.D. Anderson Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults with brain metastases in the motor cortex who've had stereotactic radiosurgery (SRS) 3-18 months prior. Participants must be able to undergo nTMS and EMG, have used MRI for SRS planning, and complete questionnaires in English. Excluded are those with significant cognitive/psychiatric issues or poor physical status that prevents participation.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Diagnostic
Patients undergo nTMS and perform tasks testing grip and pinch strength
Follow-up
Participants are monitored for safety and effectiveness after diagnostic procedures
What Are the Treatments Tested in This Trial?
Interventions
- Navigated Transcranial Magnetic Stimulation
- Stereotactic Radiosurgery
Stereotactic Radiosurgery is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator