Navigated Transcranial Magnetic Stimulation for Brain Metastasis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Brain Metastasis+1 MoreNavigated Transcranial Magnetic Stimulation - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether nTMS can help plan radiation treatment for brain metastases in the motor cortex. nTMS is a non-invasive tool that uses sensors on a patient's muscle to trace the location in their brain that controls that muscle. The trial will test whether nTMS can help doctors decide on how much radiation can be used on motor nerves.

Eligible Conditions
  • Brain Metastasis
  • Radiation Therapy Patient

Treatment Effectiveness

Study Objectives

4 Primary · 5 Secondary · Reporting Duration: Up to 1 year

Up to 1 year
Development of a clinical trial that will limit radiation dose to brain metastases
Economic feasibility of nTMS
Identification of the motor cortex by addition of nTMS
Operational feasibility of navigated transcranial magnetic stimulation (nTMS)
Presence or absence of motor deficits
Production of viable internal control by contralateral motor tract, accounting for handedness
Stereotactic radiosurgery (SRS) dosimetry and lesion involvement in the motor tracts
Technical feasibility of nTMS
Utility of electroencephalography (EEG)

Trial Safety

Trial Design

1 Treatment Group

Diagnostic (nTMS, sensory testing)
1 of 1

Experimental Treatment

22 Total Participants · 1 Treatment Group

Primary Treatment: Navigated Transcranial Magnetic Stimulation · No Placebo Group · N/A

Diagnostic (nTMS, sensory testing)Experimental Group · 4 Interventions: Hand Function Test, Navigated Transcranial Magnetic Stimulation, Quality-of-Life Assessment, Questionnaire Administration · Intervention Types: Behavioral, Procedure, Other, Other
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Navigated Transcranial Magnetic Stimulation
2019
N/A
~30

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 1 year

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,807 Previous Clinical Trials
1,790,429 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,087 Previous Clinical Trials
41,141,684 Total Patients Enrolled
Caroline ChungPrincipal InvestigatorM.D. Anderson Cancer Center
4 Previous Clinical Trials
252 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Patients must be able to participate in nTMS of bilateral motor cortices.
You must be able to participate in an EMG.
Patient must be able to complete the Functional and Quality of Life questionnaires in English.
Patient must have utilized magnetic resonance imaging (MRI) for their previous SRS treatment planning.