Artemisia Annua for Small Intestinal Bacterial Overgrowth
(HERBA-SIBO Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you do not use antibiotics or start any new medications or supplements within 30 days before the study begins. Additionally, you cannot use certain high-risk medications or drugs that need activation to work. If you're on these, you may need to stop them before joining the trial.
What data supports the effectiveness of the treatment Artemisia Annua for small intestinal bacterial overgrowth?
Is Artemisia annua safe for human use?
There have been reports of liver problems (hepatotoxicity) in people using Artemisia annua extract in grapeseed oil, with some needing hospital care. However, in a study for malaria treatment, traditional tea preparations of Artemisia annua were used without major safety concerns, though they were less effective than standard treatments.678910
How does the treatment Artemisia Annua differ from other treatments for small intestinal bacterial overgrowth?
What is the purpose of this trial?
Small intestinal bacterial overgrowth (SIBO) can cause symptoms like bloating, stomach pain, and changes in bowel movements, significantly affecting quality of life. Many people with irritable bowel syndrome (IBS) also have SIBO, and there is growing recognition of how important it is to address this condition. Artemisia annua has shown potential in managing SIBO based on early reports and studies suggesting it can fight bacteria like \*E. coli\* and \*Klebsiella\*, which are linked to a type of SIBO that produces hydrogen gas.This study aims to test if Artemisia annua is safe and well-tolerated for adults with hydrogen-type SIBO. Over five weeks, participants will take either 5 grams of dried Artemisia annua leaves or a placebo. Researchers will monitor safety through blood tests, vital signs, and adverse events, and they will assess symptom changes using questionnaires and breath tests.The trial will include up to 32 participants from the Portland, Oregon area. Participants will be randomly assigned to treatment groups, and neither they, the researchers, nor the test administrators will know who is receiving the herb or the placebo. Results will be analyzed using standard statistical methods.This study addresses the lack of research on herbal treatments for SIBO. If successful, the findings could lead to larger studies and help expand treatment options for people with SIBO.
Eligibility Criteria
Adults with hydrogen-type Small Intestinal Bacterial Overgrowth (SIBO) in the Portland, Oregon area can join this trial. It's for those who experience symptoms like bloating and stomach pain. Participants must be willing to take either an herb or a placebo without knowing which one they receive.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 5 grams of dried Artemisia annua leaves or placebo daily for 5 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Artemisia Annua
Find a Clinic Near You
Who Is Running the Clinical Trial?
National University of Natural Medicine
Lead Sponsor
atelier temenos
Collaborator