JOGO for Tremor

AS
Overseen ByAudrey Strongosky
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new treatment called JOGO for individuals with functional tremor. JOGO, a biofeedback device, uses wireless stickers to monitor muscle activity and reduce tremors through training sessions with a physical therapist. The trial aims to determine if JOGO can effectively manage tremors in the upper limbs. Individuals diagnosed with functional tremor by a Mayo Clinic Florida specialist and who have reliable internet access might be suitable candidates. As an unphased trial, this study provides a unique opportunity to explore innovative treatment options for managing tremors.

Will I have to stop taking my current medications?

You may need to stop taking certain medications if they are used to treat tremor, such as primidone, gabapentin, zonisamide, non-selective beta blockers, or benzodiazepines. If you are using medications that might cause tremor or interfere with its evaluation, you may also need to stop those. It's best to discuss your specific medications with the trial team.

What prior data suggests that this biofeedback device is safe for treating functional tremor?

Research shows that JOGO, a biofeedback device, has been safely used in individuals with chronic pain, migraines, and tremors from Parkinson's disease. Although detailed information on side effects for these specific conditions is lacking, the device's use in various areas suggests general safety. The study is labeled "Not Applicable," indicating that JOGO has already passed earlier safety tests. This designation typically means it is safe enough to focus on testing its effectiveness. Participants can expect a treatment previously used without major safety issues.12345

Why are researchers excited about this trial?

Unlike the standard treatments for tremors, which often involve medications like beta-blockers or anticonvulsants, JOGO offers a novel approach through a digital therapeutic program. Researchers are excited about JOGO because it uses a non-invasive method that focuses on neuroplasticity, potentially retraining the brain to reduce tremor symptoms. This method could offer a drug-free alternative, possibly leading to fewer side effects and making it an appealing option for those who may not respond well to traditional medications.

What evidence suggests that the JOGO device is effective for treating functional tremor?

Research has shown that JOGO, a device using biofeedback, may help treat functional tremors. Biofeedback employs sensors to track muscle activity, aiding patients in learning to control their symptoms. JOGO has proven effective for conditions such as chronic pain, migraines, and Parkinson's disease-related tremors. Studies suggest that therapy involving games like JOGO can match the effectiveness of traditional rehabilitation methods. These therapies often enhance motor skills, which are crucial for managing tremors.12367

Who Is on the Research Team?

PT

Philip Tipton, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for individuals with functional tremor, a condition causing involuntary shaking. Participants should have this specific type of tremor without other neurological disorders. Details on who can join are not fully provided.

Inclusion Criteria

Must have access to reliable internet video
Clinical diagnosis of functional tremor diagnosed by a Mayo Clinic Florida movement disorders specialist

Exclusion Criteria

Regular use of more than two units of alcohol per day
Cognitive impairment (Montreal Cognitive Assessment greater than 26)
I am currently participating in a trial for tremor treatment.
See 8 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 12-week JOGO treatment program for tremor

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

8 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • JOGO
Trial Overview The study tests JOGO, a biofeedback device using wireless sensors to monitor muscle activity and potentially control symptoms through training sessions with therapists and personal practice.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: JOGO for the Treatment of TremorExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Published Research Related to This Trial

Exergaming, using platforms like Microsoft Kinect and Wii Balance Board, has been shown to improve motor skills in Parkinson's disease patients and is considered safe and feasible for rehabilitation, even in home settings.
Clinical trials indicate that exergame-based therapy is at least as effective as traditional rehabilitation methods, with improvements in both motor and cognitive functions, highlighting its potential as a valuable treatment option for PD.
Recent advances in rehabilitation for Parkinson's Disease with Exergames: A Systematic Review.Garcia-Agundez, A., Folkerts, AK., Konrad, R., et al.[2023]

Citations

Demonstrating Efficacy of JOGO for the Treatment of TremorThis research is being done to determine the effectiveness of a new treatment, called JOGO, for patients with functional tremor (FT). JOGO is a biofeedback ...
JOGO for Tremor · Info for ParticipantsClinical trials indicate that exergame-based therapy is at least as effective as traditional rehabilitation methods, with improvements in both motor and ...
JOGO Health Announces Collaboration With Mayo Clinic to ...The study will include people who have functional tremors that are challenging to treat because they require specialized therapy instead of ...
Exploring essential tremor: Results from a large online surveyIn 33% of respondents, tremor was not treated. Abstract. Introduction. Essential tremor (ET) is one of the most common movement disorders; however ...
Focused Ultrasound for Essential Tremor: Five-Year ResultsThe 40 patients who completed the follow-up at five years maintained a 73% tremor reduction. The final long-term data report from the pivotal ...
Treatment for essential tremor: a systematic review and ...Our study results indicate that CX-8998, propranolol, and atenolol demonstrate relative efficacy and safety in treating ET.
Responsive Deep Brain Stimulator for Essential TremorThe overall objective of this early feasibility study is to provide preliminary data on the safety and efficacy of "closed-loop" deep brain ...
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