JOGO for Tremor

Overseen By Audrey Strongosky

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Mayo Clinic

Must not be taking: Primidone, Gabapentin, Zonisamide, others

Disqualifiers: Cognitive impairment, Parkinson's, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

30 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This research is being done to determine the effectiveness of a new treatment, called JOGO, for patients with functional tremor (FT). JOGO is a biofeedback device that has been shown to help patients with several conditions, e.g., chronic pain, migraine, and Parkinson's disease (PD)-related tremor. JOGO provides biofeedback by using wireless adhesive stickers, called surface electromyography, to get information about muscle activity. This information is then used to modify symptoms through a series of training sessions with a physical therapist and individual practice.

Will I have to stop taking my current medications?

You may need to stop taking certain medications if they are used to treat tremor, such as primidone, gabapentin, zonisamide, non-selective beta blockers, or benzodiazepines. If you are using medications that might cause tremor or interfere with its evaluation, you may also need to stop those. It's best to discuss your specific medications with the trial team.

How is the JOGO treatment for tremor different from other treatments?

JOGO for Tremor is unique because it likely involves a game-based rehabilitation approach, similar to other treatments for Parkinson's disease that use serious games or exergames to improve motor skills. This method is different from traditional drug therapies as it focuses on engaging patients in interactive exercises to enhance their rhythmic and motor abilities. ^{1 2 3 4 5}

What data supports the effectiveness of the treatment JOGO for tremor?

Research on similar treatments, like exergames and gaming devices such as Nintendo Wii™ and Xbox Kinect™, shows they can improve motor skills, reduce anxiety, and enhance memory and attention in people with Parkinson's disease. This suggests that game-based therapies like JOGO might also be effective for managing tremors. ^{1 2 4 6 7}

Who Is on the Research Team?

Philip Tipton, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for individuals with functional tremor, a condition causing involuntary shaking. Participants should have this specific type of tremor without other neurological disorders. Details on who can join are not fully provided.

Inclusion Criteria

Must have access to reliable internet video

Clinical diagnosis of functional tremor diagnosed by a Mayo Clinic Florida movement disorders specialist

Exclusion Criteria

Regular use of more than two units of alcohol per day

Cognitive impairment (Montreal Cognitive Assessment greater than 26)

I am currently participating in a trial for tremor treatment.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 12-week JOGO treatment program for tremor

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

8 weeks

What Are the Treatments Tested in This Trial?

Interventions

• JOGO

Trial Overview The study tests JOGO, a biofeedback device using wireless sensors to monitor muscle activity and potentially control symptoms through training sessions with therapists and personal practice.

How Is the Trial Designed?

Group I: JOGO for the Treatment of Tremor Experimental Treatment 1 Intervention

Subjects with a diagnosis of essential tremor (ET) or functional tremor (FT) involving one or more of the upper extremities will undergo a 12-week JOGO treatment program.

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+

Published Research Related to This Trial

Exergaming, using platforms like Microsoft Kinect and Wii Balance Board, has been shown to improve motor skills in Parkinson's disease patients and is considered safe and feasible for rehabilitation, even in home settings.

Clinical trials indicate that exergame-based therapy is at least as effective as traditional rehabilitation methods, with improvements in both motor and cognitive functions, highlighting its potential as a valuable treatment option for PD.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Recent advances in rehabilitation for Parkinson's Disease with Exergames: A Systematic Review. Garcia-Agundez, A., Folkerts, AK., Konrad, R., et al.[2023]

Citations

1. Netherlands pubmed.ncbi.nlm.nih.gov

Home-based training of rhythmic skills with a serious game in Parkinson's disease: Usability and acceptability. [2019]

2. England pubmed.ncbi.nlm.nih.gov

Recent advances in rehabilitation for Parkinson's Disease with Exergames: A Systematic Review. [2023]

3. United States pubmed.ncbi.nlm.nih.gov

Nintendo Wii™ Versus Xbox Kinect™ for Assisting People With Parkinson's Disease. [2022]

4. England pubmed.ncbi.nlm.nih.gov

Feasibility, safety and outcomes of playing Kinect Adventures!™ for people with Parkinson's disease: a pilot study. [2022]

5. England pubmed.ncbi.nlm.nih.gov

A technical concept of a computer game for patients with Parkinson's disease - a new form of PC-based physiotherapy. [2020]

6. United States pubmed.ncbi.nlm.nih.gov

Proposal of a Kinect(TM)-based system for gait assessment and rehabilitation in Parkinson's disease. [2020]

7. Netherlands pubmed.ncbi.nlm.nih.gov

Corticomotor excitability in Parkinson's disease during observation, imagery and imitation of action: effects of rehabilitation using wii fit and comparison to healthy controls. [2022]