Deep Brain Stimulation for Parkinson's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decreased attention, and slower processing speeds. The investigators are interested in the brain activity associated with these symptoms, and perform recordings of the surface of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
Is deep brain stimulation generally safe for humans?
Deep brain stimulation (DBS) is generally considered safe, but it can have complications. Common issues include infections, lead migrations (movement of the wires), and device malfunctions. Serious complications like permanent neurological problems occur in 4-6% of cases, and over 25% of patients may experience some kind of complication.12345
How does deep brain stimulation differ from other treatments for Parkinson's disease?
Deep brain stimulation (DBS) for Parkinson's disease is unique because it involves implanting electrodes in the brain to deliver electrical impulses, specifically targeting the subthalamic nucleus. This treatment can improve motor symptoms by altering brain activity, unlike medications that primarily increase dopamine levels. DBS can also be adjusted to optimize both motor and cognitive functions, offering a personalized approach to managing symptoms.678910
What data supports the effectiveness of the treatment Deep Brain Stimulation for Parkinson's Disease?
Research shows that Deep Brain Stimulation (DBS) of the subthalamic nucleus can improve motor symptoms in Parkinson's disease and also affects cognitive functions like response inhibition. While DBS can increase impulsive responses, it also enhances the ability to control these impulses, suggesting a complex role in managing both motor and cognitive symptoms.67111213
Who Is on the Research Team?
Nicole Bentley, MD
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for adults with Parkinson's disease or Essential Tremor who are eligible for deep brain stimulation (DBS) surgery. Candidates must be willing to participate in the study activities and have been reviewed by a multi-disciplinary team. People cannot join if they can't fully consent, aren't surgical candidates due to other health issues or pregnancy, haven't tried medical management adequately, or DBS isn't indicated for their condition.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo routine deep brain stimulation (DBS) surgery with intraoperative recordings and stimulation testing
Neural Electrophysiology Study
Participants perform various motor and cognitive tasks while brain activity is recorded from DBS and subdural strip electrodes
Follow-up
Participants are monitored for safety and effectiveness after the procedure
What Are the Treatments Tested in This Trial?
Interventions
- Response Inhibition and Deep Brain Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator