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Brain Activity Study for Cognitive Impairment in Parkinson's Disease

N/A

Recruiting

Led By Sarah Bick, MD

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age greater than or equal to 40

Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to end of deep brain stimulation (dbs), approximately 3-4 hours

Awards & highlights

Study Summary

This trial will study the brain activity of people with Parkinson's disease in order to better understand the cognitive impairments associated with the condition.

Who is the study for?

This trial is for English-speaking Parkinson's disease patients over 40, who are scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center. Participants must be able to undergo intraoperative testing and have a clinical electrode trajectory that contacts the caudate.Check my eligibility

What is being tested?

The study aims to understand cognitive impairment in Parkinson's by recording brain activity from corticostriatal structures during deep brain stimulation surgery. It will measure neural activity associated with nonmotor symptoms of the disease.See study design

What are the potential side effects?

Since this trial involves neurophysiology recordings and neural stimulation during surgery, potential side effects may include typical surgical risks like infection or bleeding, as well as any specific reactions related to deep brain stimulation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 40 years old or older.

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I am scheduled for deep brain stimulation surgery at Vanderbilt under local anesthesia.

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I have been diagnosed with Parkinson's disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to end of deep brain stimulation (dbs), approximately 3-4 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to end of deep brain stimulation (dbs), approximately 3-4 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to end of deep brain stimulation (dbs), approximately 3-4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in caudate DLPFC beta coherence

Nerve Block

Secondary outcome measures

Change in beta power with neural stimulation

Trial Design

1Treatment groups

Experimental Treatment

Group I: Neural recordings and stimulationExperimental Treatment2 Interventions

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor

857 Previous Clinical Trials

672,118 Total Patients Enrolled

Sarah Bick, MDPrincipal Investigator - Vanderbilt University Medical Center

Vanderbilt University Medical Center

1 Previous Clinical Trials

100 Total Patients Enrolled

Media Library

Neural stimulation Clinical Trial Eligibility Overview. Trial Name: NCT04715984 — N/A

Parkinson's Disease Research Study Groups: Neural recordings and stimulation

Parkinson's Disease Clinical Trial 2023: Neural stimulation Highlights & Side Effects. Trial Name: NCT04715984 — N/A

Neural stimulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04715984 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many subjects have enrolled in this research program?

"Confirmed. According to the clinical trials database, this medical experiment is presently seeking volunteers; it was initially published on June 2nd 2021 and updated on June 30th 2022. The trial necessitates 75 participants across one location."

Answered by AI

Is this trial accepting participants at the present time?

"Evidence on clinicaltrials.gov reveals that this research project is actively seeking participants, which was first published in June 2nd 2021 and most recently revised at the end of June 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Sarah Bick 2021. "Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04715984.

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