Brain Activity Study for Cognitive Impairment in Parkinson's Disease
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
Is the treatment generally safe for humans?
How does this treatment for cognitive impairment in Parkinson's disease differ from other treatments?
This treatment is unique because it focuses on brain activity related to cognitive impairment, which may involve non-dopaminergic systems that are not addressed by standard dopamine replacement therapies like levodopa. Unlike traditional treatments that primarily target motor symptoms, this approach may offer insights into cognitive aspects of Parkinson's disease.34678
What is the purpose of this trial?
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Research Team
Sarah Bick, MD
Principal Investigator
Vanderbilt University Medical Center
Eligibility Criteria
This trial is for English-speaking Parkinson's disease patients over 40, who are scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center. Participants must be able to undergo intraoperative testing and have a clinical electrode trajectory that contacts the caudate.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Deep Brain Stimulation Surgery
Neural recordings from corticostriatal structures are performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease
Follow-up
Participants are monitored for safety and effectiveness after the surgery
Treatment Details
Interventions
- Corticosteroids
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor