Deep Brain Stimulation for Parkinson's Disease
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Dual Frequency Stimulation for Parkinson's Disease?
Research shows that deep brain stimulation (DBS) with different frequency patterns can effectively manage motor symptoms in Parkinson's disease. Studies suggest that varying the frequency and pattern of DBS can enhance its effectiveness, indicating that Dual Frequency Stimulation might offer similar benefits.12345
Is deep brain stimulation generally safe for humans?
Deep brain stimulation (DBS) is generally considered safe, but it can have complications. Common issues include infections, device malfunctions, and lead migrations. Some patients may experience psychiatric effects like anxiety or depression, and about 4-6% may have permanent neurological issues.678910
How is Dual Frequency Stimulation different from other treatments for Parkinson's disease?
What is the purpose of this trial?
Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.
Research Team
Kiarash Shahlaie, MD, PhD
Principal Investigator
University of California, Davis
Eligibility Criteria
This trial is for adults with advanced Parkinson's Disease who have had a specific type of deep brain stimulation (DBS) surgery using the Boston Scientific VerciseTM system. They must be able to consent, participate in cognitive tests, and not have severe cognitive or physical impairments.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive dual frequency stimulation of the subthalamic nucleus to assess safety, tolerability, and efficacy
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Dual Frequency Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor