STAIR-NT for PTSD and Substance Abuse
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, since participants must be receiving methadone treatment, it seems you will continue with that medication.
What data supports the effectiveness of the treatment STAIR-NT for PTSD and Substance Abuse?
While there is no direct data on STAIR-NT, similar integrated cognitive-behavioral therapies like TIPSS and SDPT have shown promise in reducing PTSD symptoms and substance use. These treatments combine elements like cognitive processing therapy and relapse prevention, which have been effective in other studies.12345
Is STAIR-NT safe for treating PTSD and substance abuse?
How is the STAIR-NT treatment for PTSD and substance abuse different from other treatments?
STAIR-NT is unique because it integrates cognitive-behavioral therapy techniques specifically designed to address both PTSD and substance use disorders together, which is not commonly found in standard treatments. This approach aims to simultaneously reduce PTSD symptoms and substance use, offering a more comprehensive solution for individuals with both conditions.124910
What is the purpose of this trial?
During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulant-opioid polysubstance use. The study aims to adapt STAIR-NT to a massed treatment schedule. Once an adapted protocol is complete, it will be tested for feasibility, acceptability, and short-term polysubstance and PTSD symptomology outcomes in a pilot randomized control trial (RCT) of 80 participants. Participants who screen eligible and consent will be randomized 1:1 to the adapted STAIR-NT intervention or treatment as usual (TAU) using randomization blocks of two and two and four via a computer-generated randomization sequence. Participants assigned to the intervention will receive the adapted massed delivery of STAIR-NT by trained counselors.
Research Team
Amanda Bunting
Principal Investigator
NYU Langone Health
Eligibility Criteria
This trial is for individuals in New York City who are undergoing methadone maintenance treatment and also use stimulants and opioids. Participants should have PTSD and be willing to try a new therapy schedule. The study excludes those not meeting these specific conditions or unable to follow the trial protocol.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Adaptation Phase
Adaptation of the STAIR-NT intervention to a massed treatment schedule within the methadone maintenance treatment program
Pilot Randomized Control Trial
Testing the adapted STAIR-NT protocol for feasibility, acceptability, and short-term outcomes in a pilot RCT
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- STAIR-NT
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator