← Back to Search

Other

Oxygen (FiO2) Titration per E-alerts for Hyperoxia

Q: Are researchers currently enrolling participants for this study?

<p>According to the details provided on clinicaltrials.gov, this trial is presently in the recruitment phase. The initial posting occurred on January 15th, 2024 and the most recent update was made on January 17th, 2024.</p>

Q: What is the current number of individuals being admitted into this research investigation?

<p>Indeed, the information provided on clinicaltrials.gov indicates that this ongoing clinical trial is actively seeking eligible participants. It was initially posted on January 15th, 2024 and recently updated on January 17th, 2024. The study aims to enroll a total of 936 individuals at a single designated site.</p>

N/A

Recruiting

Research Sponsored by Ohio State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age >18 years

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, average of 28-30 days

Awards & highlights

Study Summary

This trial is comparing two methods of adjusting the oxygen levels for critically ill adults on mechanical ventilation. One group will receive reminders to adjust their oxygen based on their oxygen saturation levels, while the other group will

Who is the study for?

This trial is for adults over 18 years old who are critically ill and require mechanical ventilation. It's not suitable for those who don't meet the age requirement or aren't on mechanical breathing support.Check my eligibility

What is being tested?

The OPTI-Oxygen trial tests a new system that uses electronic alerts to help adjust oxygen levels in patients on ventilators. The goal is to see if this method, compared to standard care, better manages oxygen saturation in critically ill adults.See study design

What are the potential side effects?

Since the intervention involves adjusting existing treatment protocols rather than introducing a new medication, direct side effects from the intervention itself are not anticipated.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am older than 18 years.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, average of 28-30 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, average of 28-30 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, average of 28-30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Proportion of time during mechanical ventilation spent within target range, SpO2 of 90-94% (conservative) and SpO2 of 93-97% (liberal) with FiO2<=0.4 in respective algorithms.

Secondary outcome measures

Hospital mortality

ICU-Free Days

Length of ICU stay

+5 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Oxygen (FiO2) Titration per E-alertsExperimental Treatment1 Intervention

All eligible mechanically ventilated patients, FiO2 titration and SpO2 goal range will be based on the correlation between SpO2 and arterial oxygen saturation (SaO2). E-alerts will be sent in the intervention arm as reminders for FiO2 titration.

Group II: Oxygen Titration per Standard of CareActive Control1 Intervention

In the control arm, patients will have oxygen titrated per current standard of care (SpO2=88-92%, titrate FiO2 at least every 4 hours). Physician place oxygen titration orders in EMR and respiratory therapists conduct FiO2 titration without electronic alerts.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Ohio State UniversityLead Sponsor

830 Previous Clinical Trials

504,684 Total Patients Enrolled

2 Trials studying Hyperoxia

5,702 Patients Enrolled for Hyperoxia

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,840 Previous Clinical Trials

47,851,188 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are researchers currently enrolling participants for this study?

"According to the details provided on clinicaltrials.gov, this trial is presently in the recruitment phase. The initial posting occurred on January 15th, 2024 and the most recent update was made on January 17th, 2024."

Answered by AI

What is the current number of individuals being admitted into this research investigation?

"Indeed, the information provided on clinicaltrials.gov indicates that this ongoing clinical trial is actively seeking eligible participants. It was initially posted on January 15th, 2024 and recently updated on January 17th, 2024. The study aims to enroll a total of 936 individuals at a single designated site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen)

Sonal Pannu 2024. "Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05923853.