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Behavioural Intervention

Exercise Training for Older Adults With Multiple Sclerosis

N/A
Recruiting
Led By Peixuan Zheng, PhD
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up changes in msis-29 scores from baseline (pre-intervention), after 16 weeks (post-intervention), and after 32 weeks (follow-up)
Awards & highlights

Study Summary

This trial will test if a 16-week home-based exercise program can improve cognitive and physical function in MS patients aged 50+. Participants will be randomly assigned to an exercise or active control (stretching) group.

Who is the study for?
This trial is for adults aged 50 or older with Multiple Sclerosis who can walk (with or without help) and have mild-to-moderate cognitive impairment. They must have internet access, be able to visit the lab for tests, and not have had an MS relapse in the last month. People with other neurological conditions, cardiovascular diseases, or a high risk of injury from exercise cannot join.Check my eligibility
What is being tested?
The study is testing if a home-based exercise program combining aerobic and resistance training can improve thinking skills and mobility in older adults with MS compared to a flexibility/stretching program. The exercises are done over Zoom calls with coaches for 16 weeks, followed by another 16 weeks to see if benefits last.See study design
What are the potential side effects?
Since this trial involves physical exercise programs, potential side effects may include muscle soreness, fatigue, joint pain or discomfort during activities. Serious risks like injuries are minimized by excluding those at high risk.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~changes in walking speed scores from baseline (pre-intervention), after 16 weeks (post-intervention), and after 32 weeks (follow-up)
This trial's timeline: 3 weeks for screening, Varies for treatment, and changes in walking speed scores from baseline (pre-intervention), after 16 weeks (post-intervention), and after 32 weeks (follow-up) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cognitive Function
Functional Mobility
Lower-extremity Function
+3 more
Secondary outcome measures
Exercise Behavior
Physical Activity Level
Vascular Function
Other outcome measures
Anxiety
Depressive Symptoms
Fatigue Impact
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic and Resistance Exercise Program (GEMS program)Experimental Treatment1 Intervention
This intervention condition will deliver the Guidelines for Exercise in Multiple Sclerosis (GEMS) program. Participants in this condition will receive a 16-week home-based, remotely supported aerobic and resistance exercise training intervention.
Group II: Flexibility and Stretching Program (FLEX-MS program)Active Control1 Intervention
Participants in this condition will receive a 16-week home-based, remotely supported stretching program emphasizing flexibility and range of motion as important components of fitness based on Stretching for People with MS: An Illustrated Manual from the National MS Society.

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor
609 Previous Clinical Trials
1,559,259 Total Patients Enrolled
13 Trials studying Multiple Sclerosis
1,656 Patients Enrolled for Multiple Sclerosis
Peixuan Zheng, PhDPrincipal InvestigatorUniversity of Illinois at Chicago

Media Library

Aerobic and Resistance Exercise Program (GEMS program) (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05930821 — N/A
Multiple Sclerosis Research Study Groups: Flexibility and Stretching Program (FLEX-MS program), Aerobic and Resistance Exercise Program (GEMS program)
Multiple Sclerosis Clinical Trial 2023: Aerobic and Resistance Exercise Program (GEMS program) Highlights & Side Effects. Trial Name: NCT05930821 — N/A
Aerobic and Resistance Exercise Program (GEMS program) (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05930821 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies in this clinical research study that participants can join?

"Data published on clinicaltrials.gov verifies that this research is recruiting volunteers. The initial posting was made on July 5th 2023, with the most recent update occurring simultaneously."

Answered by AI

What is the current enrollment number for this trial?

"Affirmative, active recruitment for the trial is specified on clinicaltrials.gov. The medical experiment was initially announced on July 5th 2023 and has been updated as recently as that same date. A total of 50 participants are needed from a single site to complete this study."

Answered by AI

Who else is applying?

What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
Peixuan Zheng 2023. "Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05930821.
~0 spots leftby May 2024
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