Creatine + Resistance Training for Prostate Cancer
(CREATINE-52 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to test the use of creatine monohydrate supplementation with resistance training to preserve muscle mass and help lessen prostate cancer progression.The main question it aims to answer is if this treatment will help maintain muscle mass to help in reducing fatigue and improving physical function, independence, and quality of life.Participants will be asked to participate in a 52-week exercise intervention consisting of a twice weekly telehealth resistance training program.
Will I have to stop taking my current medications?
The trial does not specify that you need to stop your current medications. However, you must be on a stable regimen of certain prostate cancer treatments for at least 12 weeks before joining the trial.
Is creatine supplementation safe for humans?
Creatine monohydrate is generally considered safe for humans when taken at recommended doses, with common side effects being mild, such as temporary water retention. Studies have shown no serious adverse effects, and a daily intake of 3 grams is unlikely to pose safety concerns for healthy adults, though caution is advised for certain forms like creatine orotate and creatine phosphate.12345
How does the creatine monohydrate treatment differ from other prostate cancer treatments?
Creatine monohydrate combined with resistance training is unique because it focuses on enhancing muscle strength and energy levels, which may help improve quality of life for prostate cancer patients, especially those undergoing home-based telehealth programs. Unlike standard treatments like chemotherapy or immunotherapy, this approach is non-invasive and can be administered at home, potentially offering a supportive role alongside traditional therapies.678910
Who Is on the Research Team?
Adriana Coletta
Principal Investigator
Huntsman Cancer Institute/ University of Utah
Are You a Good Fit for This Trial?
Men over 18 with metastatic prostate cancer not currently progressing on therapy can join. They must be undergoing hormone treatments, have internet access for video calls, and be willing to do a home-based exercise program and take creatine or placebo as assigned.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 52 weeks of home-based, telehealth resistance training with creatine monohydrate supplementation or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Creatine Monohydrate
- Home-based, telehealth
Creatine Monohydrate is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
National Institutes of Health (NIH)
Collaborator