Exercise Group 1 for Progressive Multiple Sclerosis (PMS)

Phase-Based Progress Estimates
University of Regina, Regina, Canada
Progressive Multiple Sclerosis (PMS)+3 More
Exercise Group 1 - Other
All Sexes
What conditions do you have?

Study Summary

A growing body of work suggests that regular exercise can support symptom management and improve physical function for people living with progressive multiple sclerosis (MS). However, the best type of exercise to improve physical function and promote positive changes in the central nervous system in people with progressive MS is not well characterized. Here, the investigators have designed a clinical trial that compares the effects of distinct exercise protocols on aspects of physical function, physical fitness, and central nervous system function in people living with progressive MS.

Eligible Conditions

  • Progressive Multiple Sclerosis (PMS)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Progressive Multiple Sclerosis (PMS)

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 6 weeks post intervention

6 weeks post intervention
9-Hole Pegboard Test
Brain-Derived Neurotrophic Factor in systemic blood
Mini Balance Evaluation Systems Test
Motor Evoked Potential Amplitude
Multiple Sclerosis Impact Scale
Neurofilament Light concentration in systemic blood
Peak Isometric Hand Grip Force
Peak Isometric Knee Extensor Torque
Peak Oxygen Uptake
Symbol Digit Modalities Test
Timed 25-Foot Walk Test
Tumor Necrosis Factor Alpha concentration in systemic blood

Trial Safety

Safety Progress

1 of 3

Other trials for Progressive Multiple Sclerosis (PMS)

Trial Design

3 Treatment Groups

Exercise Group 2
1 of 3
Exercise Group 1
1 of 3
Exercise Group 3
1 of 3
Active Control
Experimental Treatment
Non-Treatment Group

69 Total Participants · 3 Treatment Groups

Primary Treatment: Exercise Group 1 · Has Placebo Group · N/A

Exercise Group 1
Experimental Group · 1 Intervention: Exercise Group 1 · Intervention Types: Other
Exercise Group 3
ShamComparator Group · 1 Intervention: Exercise Group 3 · Intervention Types: Other
Exercise Group 2
ActiveComparator Group · 1 Intervention: Exercise Group 2 · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 weeks post intervention
Closest Location: University of Regina · Regina, Canada
2012First Recorded Clinical Trial
1 TrialsResearching Progressive Multiple Sclerosis (PMS)
14 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are cleared by your physician to exercise.
You have a PDSS score between 2 and 6.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.