147 Participants Needed

Breathing Practice for Multiple Sclerosis and Cancer

CT
Overseen ByClinical Trials Referral Office
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Breathing Practice for Multiple Sclerosis and Cancer?

Research shows that deep breathing can help reduce anxiety and fatigue in cancer patients, and breathing exercises as part of yoga programs have been beneficial for people with multiple sclerosis, improving their quality of life and symptom management.12345

Is breathing practice safe for people with multiple sclerosis?

Breathing practices, including those used in yoga and mind-body therapies, are generally considered safe for people with multiple sclerosis and may offer non-drug benefits for managing symptoms.26789

How does the breathing practice treatment differ from other treatments for multiple sclerosis and cancer?

The breathing practice treatment is unique because it focuses on mind-body techniques like meditation and deep breathing, which aim to improve quality of life, mood, and reduce stress and fatigue, rather than directly targeting the disease itself. This approach is different from conventional treatments that typically involve medication or surgery.1341011

What is the purpose of this trial?

This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relationship between respiration, cardiovascular effects in the brain, mental health, and neurophysiological mechanisms are significant for patient populations facing complex health challenges, such as those with cancer and neurodegenerative disease, and their caregivers. By measuring oxygen delivery to brain tissues and cerebrospinal fluid flow, this trial may help researchers investigate the potential benefits of respiratory training for patients with MS and cancer and their caregivers.

Research Team

PH

Paul H. Min, PhD

Principal Investigator

Mayo Clinic in Rochester

Eligibility Criteria

This trial is for patients with multiple sclerosis or various cancers, including neuroendocrine and prostate cancer, as well as their caregivers. It aims to explore how breathing exercises can improve brain and mental health.

Inclusion Criteria

STUDY 2: They also must have access to a smartphone or tablet
STUDY 1: Participants must be physically fit enough to perform light exercise
STUDY 1: Must have access to a smartphone or tablet
See 9 more

Exclusion Criteria

STUDY 1: Participants incompatible with MRI machines due to factors such as pacemakers or metallic implants
STUDY 1: Participants with psychiatric conditions such as psychosis, suicidality, bipolar disorder, major depression, and substance use disorders are excluded
I do not have chronic conditions like heart disease, COPD, diabetes, or neurological disorders.
See 7 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in breathing or walking self-practice routines using a mobile app over 30 minutes daily for 4 months. Participants may participate in real-time online or in-person sessions with instructors.

4 months
Weekly online sessions, monthly in-person sessions

Extended Treatment

Participants continue or discontinue their self-practice routines for an additional 2 months, with some groups combining breathing and walking practices.

2 months
Weekly online sessions, monthly in-person sessions

Follow-up

Participants are monitored for changes in respiratory function, brain activity, and quality of life measures using MRI and various questionnaires.

2 months

Treatment Details

Interventions

  • Breathing Practice
Trial Overview The study tests respiratory training's effects on the brain and mental health by using questionnaires, MRI scans, biospecimen collection, and exercise interventions to measure changes in oxygen delivery to the brain.
Participant Groups
7Treatment groups
Experimental Treatment
Active Control
Group I: Study 3 Subgroup 6 (4 months breathing sessions)Experimental Treatment4 Interventions
MS patients engage in breathing self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. MS patients then discontinue breathing self-practice routines for the additional 2 months on study. Patients also undergo MRI scans and blood sample collection throughout the study.
Group II: Study 3 Subgroup 5 (6 month breathing sessions)Experimental Treatment4 Interventions
MS patients engage in breathing self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. MS patients then engage in breathing self-practice routines using a mobile app over 30 minutes daily for an additional 2 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. Patients also undergo MRI scans and blood sample collection throughout the study.
Group III: Study 2 (4 month breathing sessions)Experimental Treatment3 Interventions
Cancer patients and their caregivers engage in breathing self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. Participants also undergo MRI scans throughout the study.
Group IV: Study 1 Group 2, Subgroup 4 (walking + breathing)Experimental Treatment4 Interventions
Participants engage in walking self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may also participate in in-person group walking session with other participants weekly on study. Participants then engage in walking self-practice routines using a mobile app over 30 minutes daily for an additional 2 months and also engage in breathing self-practice routines using a mobile app over 30 minutes daily for 2 months on study. Participants may also participate in in-person group walking session with other participants weekly on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. Participants also undergo MRI scans throughout the study.
Group V: Study 1 Group 1, Subgroup 2 (4 month breathing sessions)Experimental Treatment3 Interventions
Participants engage in breathing self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. Participants then discontinue breathing self-practice routines for the additional 2 months on study. Participants also undergo MRI scans throughout the study.
Group VI: Study 1 Group 1, Subgroup 1 (6 month breathing sessions)Experimental Treatment3 Interventions
Participants engage in breathing self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. Participants then engage in breathing self-practice routines using a mobile app over 30 minutes daily for an additional 2 months on study. Participants may participate in real-time online breathing sessions with instructors weekly on study. Participants may also participate in in-person breathing sessions with instructors monthly on study. Participants also undergo MRI scans throughout the study.
Group VII: Study 1 Group 2, Subgroup 3 (6 month walking routines)Active Control3 Interventions
Participants engage in walking self-practice routines using a mobile app over 30 minutes daily for 4 months on study. Participants may also participate in in-person group walking session with other participants weekly on study. Participants then engage in walking self-practice routines using a mobile app over 30 minutes daily for an additional 2 months on study. Participants may also participate in in-person group walking session with other participants weekly on study. Participants also undergo MRI scans throughout the study.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Findings from Research

In a study involving 23 Japanese women with gynaecological cancer undergoing chemotherapy, a 10-minute deep breathing intervention significantly reduced 'tension-anxiety' and fatigue compared to a control group.
The results suggest that deep breathing can be an effective complementary therapy to help alleviate emotional and physical distress in cancer patients during treatment.
The effects of deep breathing on 'tension-anxiety' and fatigue in cancer patients undergoing adjuvant chemotherapy.Hayama, Y., Inoue, T.[2022]
An 8-week online adaptive yoga program for patients with multiple sclerosis was found to be safe and enjoyable, with all participants reporting perceived benefits from their involvement.
Participants not only experienced improvements in their perceived symptom severity and quality of life but also valued the social interaction with fellow patients during the program.
Exploring an 8-Week Online Adaptive Yoga Program for Multiple Sclerosis: A Pilot Study.Robert, MK., Hales Reynolds, MA., Eisenberg, M., et al.[2023]
In a study of 60 women undergoing radiation therapy for breast cancer, those practicing pranayama showed improved sleep quality, while the control group experienced increased fatigue levels by the end of treatment.
Pranayama is a simple and equipment-free exercise that can be easily taught by oncology nurses, making it a practical option for managing symptoms like fatigue and sleep disturbances in cancer patients.
The Effects of Pranayama or Deep Breathing Exercises on Fatigue and Sleep Quality in Women Receiving Radiation Therapy for Breast Cancer.Gündogdu, F., Koçaşlı, S.[2023]

References

The effects of deep breathing on 'tension-anxiety' and fatigue in cancer patients undergoing adjuvant chemotherapy. [2022]
Exploring an 8-Week Online Adaptive Yoga Program for Multiple Sclerosis: A Pilot Study. [2023]
The Effects of Pranayama or Deep Breathing Exercises on Fatigue and Sleep Quality in Women Receiving Radiation Therapy for Breast Cancer. [2023]
Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. [2023]
Medical Qigong for cancer patients: pilot study of impact on quality of life, side effects of treatment and inflammation. [2019]
A crossover pilot trial of the feasibility, acceptability, and effectiveness of LoveYourBrain Yoga for community-dwelling adults with multiple sclerosis. [2022]
Deep breathing exercises with positive expiratory pressure in patients with multiple sclerosis - a randomized controlled trial. [2017]
Undertaking specific stress-reducing activities are associated with reduced fatigue and depression, and increased mastery, in people with multiple sclerosis. [2022]
Mind-body medicine for multiple sclerosis: a systematic review. [2021]
10.United Statespubmed.ncbi.nlm.nih.gov
A Prospective Pilot Study Evaluating Feasibility and Preliminary Effects of Breathe Easier: A Mindfulness-based Intervention for Survivors of Lung Cancer and Their Family Members (Dyads). [2021]
11.United Statespubmed.ncbi.nlm.nih.gov
Randomized Feasibility Study of Meditative Practices in Hospitalized Cancer Patients. [2021]
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